Nitric oxide: physiology, pathophysiology, and pharmacology.

Measurement of Nitric Oxide Production in Biological Systems by Using Griess Reaction Assay

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T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm

Nakayama, M., Yasue, H., Yoshimura, M., Shimasaki, Y., Kugiyama, K., Ogawa, H., Motoyama, T., Saito, Y., Ogawa, Y., Miyamoto, Y., et al. (1999) · Circulation · doi:10.1161/01.cir.99.22.2864 · Cited by 777

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft

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Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome

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Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

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Nitric oxide and redox mechanisms in the immune response

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Free Radical Pathways in CNS Injury

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Generation of superoxide by purified brain nitric oxide synthase

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Calcium Movements, Distribution, and Functions in Smooth Muscle

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Nitric oxide, a novel biologic messenger

Lowenstein, C. J., & Snyder, S. H. (1992) · Cell · doi:10.1016/0092-8674(92)90301-r · Cited by 740

New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

Baylis, C., Mitruka, B. M., & Deng, A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115849 · Cited by 729

Low-Dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension of the Newborn

Clark, R. H., Kueser, T. J., Walker, M. W., Southgate, W. M., Huckaby, J., Perez, J. A. R., Roy, B. J., Keszler, M., & Kinsella, J. P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420704 · Cited by 726

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A., Tilton, R. G., McDaniel, M. L., Williamson, J. R., & Currie, M. G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90357-n · Cited by 722

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

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Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 717

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

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Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

Farrell, A. J., Blake, D. R., Palmer, R. M. J., & Moncada, S. (1992) · Annals of the Rheumatic Diseases · doi:10.1136/ard.51.11.1219 · Cited by 717

The physiology and pathophysiology of nitric oxide in the brain

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Superoxide Generation from Endothelial Nitric-oxide Synthase

Xia, Y., Tsai, A.-L., Berka, V., & Zweier, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25804 · Cited by 705

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

Kaur, H., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706

Vascular Adrenoceptors: An Update

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Redox signaling: hydrogen peroxide as intracellular messenger

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The "Retinoic Acid Syndrome" in Acute Promyelocytic Leukemia

Frankel, S. R., Eardley, A., Lauwers, G. Y., Weiss, M. A., & Warrell, R. P. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-292 · Cited by 701

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697

Biochemical Reactivity of Melatonin with Reactive Oxygen and Nitrogen Species: A Review of the Evidence

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Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

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Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique

Stefanovska, A., Bračič, M., & Kvernmo, H. D. (1999) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.790500 · Cited by 695

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria

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Superoxide and peroxynitrite inatherosclerosis.

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Oxidative Stress in Brain Ischemia

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Role of TNF-α in vascular dysfunction

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The multifaceted roles of nitric oxide in cancer

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Base excision repair of oxidative DNA damage and association with cancer and aging

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Reactive nitrogen species in the chemical biology of inflammation

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The Importance of the Hyperpolarizing Mechanism Increases as the Vessel Size Decreases in Endothelium-Dependent Relaxations in Rat Mesenteric Circulation

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Endothelial Dysfunction: Does It Matter? Is It Reversible?

Celermajer, D. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00189-7 · Cited by 679

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

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Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery

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Pulmonary Arterial Hypertension

McLaughlin, V. V., & McGoon, M. D. (2006) · Circulation · doi:10.1161/circulationaha.104.503540 · Cited by 667

Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation

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Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

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Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

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Intragastric nitric oxide production in humans: measurements in expelled air.

Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

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Bradykinin and inflammatory pain

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Determination of nitrite/nitrate in human biological material by the simple Griess reaction

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Intracellular cyclic GMP receptor proteins

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Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

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Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

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Suppression of arthritis by an inhibitor of nitric oxide synthase.

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The 1991 Ulf von Euler Lecture:The l ‐arginine: nitric oxide pathway

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Free radicals and antioxidants in food andin vivo:What they do and how they work

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Oxygen-derived species: their relation to human disease and environmental stress.

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Nitric oxide and cancer: a review

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Calmodulin is a subunit of nitric oxide synthase from macrophages.

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Neuroendocrine Control of Growth Hormone Secretion

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Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

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Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

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Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases

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Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

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Endothelial Cell Metabolism in Normal and Diseased Vasculature

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Nitric oxide synthase activity in human breast cancer

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TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

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Cellular Response of Pea Plants to Cadmium Toxicity: Cross Talk between Reactive Oxygen Species, Nitric Oxide, and Calcium

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DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

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Regulation of retinal blood flow in health and disease

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High-Capacity Hydrogen and Nitric Oxide Adsorption and Storage in a Metal−Organic Framework

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Induction and potential biological relevance of a Ca2+‐independent nitric oxide synthase in the myocardium

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Comparative properties of arginases

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Myeloperoxidase-generated oxidants and atherosclerosis

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Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

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Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

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Role of nitric oxide in the biology, physiology and pathophysiology of reproduction

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Severity of E. coli mastitis is mainly determined by cow factors

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Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action

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Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

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The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation

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Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

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Strategies to increase nitric oxide signalling in cardiovascular disease

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Flow-Mediated Dilation and Cardiovascular Event Prediction

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The physiological role of nitric oxide

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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NO-independent regulatory site on soluble guanylate cyclase

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