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Nitric oxide: physiology, pathophysiology, and pharmacology.
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In the citing paper
“However, nitrate is the dominating final oxidation product in plasma with concentrations (micromolar) normally at least 2 orders of magnitude higher than nitrite (nanomolar).35”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [35]
In the citing paper
“A large number of cytokines and hormones have been shown to induce NOX2 expression, including angiotensin II (658, 714, 802), thrombin (725), and TNF-α (275, 964).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [658]
In the citing paper
“Nitric oxide (NO; nitrogen monoxide) and related nitrogen oxides are now known to be critical endogenous regulators of cell and tissue function (1, 2).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [1]
In the citing paper
“However, studies suggest that nitrate and nitrite may act as a substrate for eNOS-mediated NO generation, even when oxygen levels are limited.”
From The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies (2013) · cites this paper as [98]
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Items 1,101–1,126 of 1,126
Hoffman, M. D., Walsh, G. M., Rogalski, J. C., & Kast, J. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800230-mcp200 · Cited by 41
Van der Schueren, B. J., Lunnon, M. W., Laurijssens, B. E., Guillard, F., Palmer, J., Van Hecken, A., Depré, M., Vanmolkot, F. H., & de Hoon, J. N. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270008329548 · Cited by 39
Kostka, P. (1995) · Analytical Chemistry · doi:10.1021/ac00108a023 · Cited by 38
Rafikov, R., Rafikova, O., Aggarwal, S., Gross, C., Sun, X., Desai, J., Fulton, D., & Black, S. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.423269 · Cited by 36
NO-ferroheme is a signaling entity in the vasculature
Kleschyov, A. L., Zhuge, Z., Schiffer, T. A., Guimarães, D. D., Zhang, G., Montenegro, M. F., Tesse, A., Weitzberg, E., Carlström, M., & Lundberg, J. O. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01411-5 · Cited by 36
ORSI, A., BELTRÁN, B., CLEMENTI, E., HALLÉN, K., FEELISCH, M., & MONCADA, S. (2000) · Biochemical Journal · doi:10.1042/bj3460407 · Cited by 37
Self-citationNitric oxide influences red blood cell velocity independently of changes in the vascular tone
Horn, P., Cortese-Krott, M. M., Keymel, S., Kumara, I., Burghoff, S., Schrader, J., Kelm, M., & Kleinbongard, P. (2011) · Free Radical Research · doi:10.3109/10715762.2011.574288 · Cited by 34
Rodríguez-Juárez, F., Aguirre, E., & Cadenas, S. (2007) · Biochemical Journal · doi:10.1042/bj20070033 · Cited by 31
Ables, G. P., Takamatsu, D., Noma, H., El-Shazly, S., Jin, H. K., Taniguchi, T., Sekikawa, K., & Watanabe, T. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001459169 · Cited by 30
MILES, D., THOMSEN, L., BALKWILL, F., THAVASU, P., & MONCADA, S. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb01087.x · Cited by 26
Self-citationPEGylated Polymer Micelle-based Nitric Oxide (NO) Photodonor with NO-mediated Antitumor Activity
Kanayama, N., Yamaguchi, K., & Nagasaki, Y. (2010) · Chemistry Letters · doi:10.1246/cl.2010.1008 · Cited by 25
Goret, L., Tanguy, S., Guiraud, I., Dauzat, M., & Obert, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.037 · Cited by 24
l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia
Córdova-Martínez, A., Caballero-García, A., Bello, H. J., Pons-Biescas, A., Noriega, D. C., & Roche, E. (2022) · Pharmaceuticals · doi:10.3390/ph15030290 · Cited by 21
Enzymatic/non-enzymatic formation of nitric oxide
Meyer, D. J. (1995) · Nature Medicine · doi:10.1038/nm1195-1103a · Cited by 20
Adamek, M., Kawczyk-Krupka, A., Mostowy, A., Czuba, Z., Krol, W., Kasperczyk, S., Jakobisiak, M., Golab, J., & Sieron, A. (2005) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(05)00004-9 · Cited by 19
Plasma nitrate plus nitrite changes during continuous intravenous infusion interleukin 2
Citterio, G., Pellegatta, F., Lucca, G., Fragasso, G., Scaglietti, U., Pini, D., Fortis, C., Tresoldi, M., & Rugarli, C. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.533 · Cited by 18
Goto, T. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00008-x · Cited by 17
Yamada, J., Sugimoto, Y., Yoshikawa, T., & Horisaka, K. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00657-7 · Cited by 16
Sugimoto, Y., Yamada, J., & Yoshikawa, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00378-7 · Cited by 16
Czech, D. A., Kazel, M. R., & Harris, J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00220-8 · Cited by 16
Silva, M. P. D., Cedraz-Mercez, P. L., & Varanda, W. A. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133326 · Cited by 16
Tian, C., Jiang, Q., Han, M., Guo, L., Huang, R., Zhao, L., & Mao, S. (2025) · Nutrients · doi:10.3390/nu17121958 · Cited by 16
Non-steroidal Anti-inflammatory Drugs and Pain
Appleton, I. (1997) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-60777-6_3 · Cited by 11
Changes in nitric oxide metabolite levels in stimulated substantia nigra neurons
Zecca, L., Fariello, R. G., Galimberti, M., Racagni, G., & Ambrosini, A. (1997) · NeuroReport · doi:10.1097/00001756-199707070-00007 · Cited by 11
Involvement of nitric oxide in the 5-HT1A autoreceptor-mediated hyperphagia in rats
Sugimoto, Y., Yoshikawa, T., & Yamada, J. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4709-9_16 · Cited by 9
Saltpetre in Early and Medieval Chinese Medicine
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Metadata
- Authors
- Moncada, S., Palmer, R. M., & Higgs, E. A.
- Affiliations
- Wellcome Trust (GB)
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 43
- Issue
- 2
- Pages
- 109-142
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W1929009802
- Cited by
- 15,525
- References
- 0
- Citations by year
- 2026: 60 · 2025: 87 · 2024: 63 · 2023: 121 · 2022: 122 · 2021: 132 · 2020: 169 · 2019: 187 · 2018: 220 · 2017: 250 · 2016: 273 · 2015: 299 · 2014: 394 · 2013: 379 · 2012: 463
- FWCI
- 354.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- nitric oxide, nitric oxide synthase, soluble guanylate cyclase, cGMP signaling
- MeSH terms
- Animals, Blood Platelets, Blood Vessels, Nervous System, Nitric Oxide, Rabbits
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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