Cited by 809Nutrition and Health in AgingMuscle Physiology and DisordersHormonal and reproductive studies

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Predictors of skeletal muscle mass in elderly men and women

Baumgartner, Richard N., Waters, Debra L., Gallagher, Dympna, Morley, John E., Garry, Philip J.·1999·Mechanisms of Ageing and Development

DOI 10.1016/s0047-6374(98)00130-4

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Abstract

Background Elderly men and women lose muscle mass and strength with increasing age. Decreased physical activity, hormones, malnutrition and chronic disease have been identified as factors contributing to this loss. There are few data, however, for their multivariate associations with muscle mass and strength. This study analyzes these associations in a cross-sectional sample of elderly people from the New Mexico Aging Process Study.Methods Data collected in 1994 for 121 male and 180 female volunteers aged 65-97 years of age enrolled in The New Mexico Aging Process Study were analyzed. Body composition was measured using dual energy X-ray absorptiometry; dietary intake from 3 day food records; usual physical activity by questionnaire; health status from annual physical examinations; and serum testosterone, estrone, sex-hormone binding globulin (SHBG), and insulin-like growth factor (IGF1) from radioimmunoassays of fasting blood samples. Statistical analyses included partial correlation and stepwise multiple regression.Results The muscle mass and strength (adjusted for knee height) decreased with increasing age in both sexes. The muscle mass was significantly associated with serum free-testosterone, physical activity, cardiovascular disease, and IGF1 in the men. In the women, the muscle mass was significantly associated with total fat mass and physical activity. Age was not associated significantly with muscle mass after controlling for these variables. Grip strength was associated with age independent of muscle mass in both sexes. Estrogen (endogenous and exogenous) was not associated with muscle mass or strength in women.Conclusions Age-related loss of muscle mass and strength occurs in relatively healthy, well-nourished elderly men and women and has a multifactorial basis. Sex hormone status is an important factor in men but not in women. Physical activity is an important predictor of muscle mass in both sexes.

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“For instance, although the SARC-F is a validated tool [8] and practical for use in community settings [9, 10], future studies would benefit from the inclusion of objec-tive measures, such as accelerometers for physical activity, handgrip strength dynamometry, gait speed tests, and imaging-based…”
Influential
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“변화(성장호르몬, 인슐린양 성장인자-1, 테스토스테론, 안 드로젠, 에스트로젠, 인슐린, 코르티코이드 등의 감소 및 저 항성 증가) [15-18], 죽상경화증[19] 및 염증성 사이토카인”

Authors: Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J.
Affiliations: University of New Mexico (US)
St. Luke's-Roosevelt Hospital Center (US)
St. Louis VA Medical Center (US)
Corresponding author: Morley, John E.
ORCID: Baumgartner, Richard N.
Waters, Debra L.
Gallagher, Dympna
Morley, John E.
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 1999-03
Volume: 107
Issue: 2
Pages: 123-136
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/s0047-6374(98)00130-4
OpenAlex: W2042178933
Cited by: 809
References: 34
Citations by year: 2026: 9 · 2025: 28 · 2024: 23 · 2023: 22 · 2022: 38 · 2021: 29 · 2020: 33 · 2019: 26 · 2018: 42 · 2017: 40 · 2016: 34 · 2015: 26 · 2014: 35 · 2013: 46 · 2012: 44
FWCI: 9.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (R01AG010149, AG 02049, AG 10149)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: skeletal muscle mass, muscle strength, sarcopenia, aging, older adults, sex differences, physical activity, sex hormones, free testosterone, estrone, sex hormone-binding globulin, insulin-like growth factor I, grip strength, fat mass, cardiovascular disease, body composition
MeSH terms: Aged, Aged, 80 and over, Aging, Body Composition, Female, Humans, Male, Muscle, Skeletal

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Predictors of skeletal muscle mass in elderly men and women

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