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Life Extension in the Dwarf Mouse
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Cites
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
Premature mortality due to cardiovascular disease in hypopituitarism
Rosén, T., & Bengtsson, B.-Å. (1990) · The Lancet · doi:10.1016/0140-6736(90)91812-o · Cited by 1,402
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Thyroid Status, Disability and Cognitive Function, and Survival in Old Age
Gussekloo, J. (2004) · JAMA · doi:10.1001/jama.292.21.2591 · Cited by 899
Insulin resistance as a predictor of age-related diseases
Facchini, F. S., Hua, N., Abbasi, F., & Reaven, G. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7763 · Cited by 594
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575
Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability
Papadakis, M. A., Grady, D., Black, D., Tierney, M. J., Gooding, G. A. W., Schambelan, M., & Grunfeld, C. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-8-199604150-00002 · Cited by 474
Extending the Lifespan of Long-Lived Mice
Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S. (2001) · Nature · doi:10.1038/35106646 · Cited by 422
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Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
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Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
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Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420
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Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 402
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Mitchell, S. J., Scheibye-Knudsen, M., Longo, D. L., & de Cabo, R. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110829 · Cited by 328
Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.016 · Cited by 293
Extreme Longevity Is Associated with Increased Serum Thyrotropin
Atzmon, G., Barzilai, N., Hollowell, J. G., Surks, M. I., & Gabriely, I. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2325 · Cited by 260
Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms
Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van IJcken, W., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000161 · Cited by 212
Self-citationInsulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-κB signaling
Salminen, A., & Kaarniranta, K. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2009.10.006 · Cited by 177
FGF21-based pharmacotherapy – potential utility for metabolic disorders
Gimeno, R. E., & Moller, D. E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.03.001 · Cited by 163
Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.16.13120 · Cited by 160
Calcium signaling alterations, oxidative stress, and autophagy in aging
Ureshino, R. P., Rocha, K. K., Lopes, G. S., Bincoletto, C., & Smaili, S. S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5777 · Cited by 143
Garinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., van Steeg, H., Mullenders, L. H. F., van der Horst, G. T. J., Brüning, J. C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1866 · Cited by 138
Sex-specific regulation of aging and apoptosis
Tower, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.001 · Cited by 125
Identification of potential caloric restriction mimetics by microarray profiling
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Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117
Evolutionary origins of insulin resistance: a behavioral switch hypothesis
Watve, M. G., & Yajnik, C. S. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-61 · Cited by 114
IGF‐I regulates the age‐dependent signaling peptide humanin
Lee, C., Wan, J., Miyazaki, B., Fang, Y., Guevara‐Aguirre, J., Yen, K., Longo, V., Bartke, A., & Cohen, P. (2014) · Aging Cell · doi:10.1111/acel.12243 · Cited by 80
Self-citationRegulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice
Dominick, G., Berryman, D. E., List, E. O., Kopchick, J. J., Li, X., Miller, R. A., & Garcia, G. G. (2015) · Endocrinology · doi:10.1210/en.2014-1690 · Cited by 79
Diminished mTOR signaling: a common mode of action for endocrine longevity factors
Lamming, D. W. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-735 · Cited by 71
The Shc locus regulates insulin signaling and adiposity in mammals
Tomilov, A. A., Ramsey, J. J., Hagopian, K., Giorgio, M., Kim, K. M., Lam, A., Migliaccio, E., Lloyd, K. C., Berniakovich, I., Prolla, T. A., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00641.x · Cited by 64
“Also, some long-lived rodents, such as Ames, Snell and little mice, and GHRKO mice (Hsieh et al., 2002b; Amador-Noguez et al., 2004; Bartke & Brown-Borg, 2004), have more fat than controls at the end of life.”
BackgroundDominick, G., Bowman, J., Li, X., Miller, R. A., & Garcia, G. G. (2017) · Aging Cell · doi:10.1111/acel.12525 · Cited by 62
Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice
Brown-Borg, H. M., Johnson, W. T., & Rakoczy, S. G. (2012) · AGE · doi:10.1007/s11357-011-9212-x · Cited by 52
Self-citationLee, J. S., Ward, W. O., Ren, H., Vallanat, B., Darlington, G. J., Han, E.-S., Laguna, J. C., DeFord, J. H., Papaconstantinou, J., Selman, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.006 · Cited by 44
Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri
Priami, C., De Michele, G., Cotelli, F., Cellerino, A., Giorgio, M., Pelicci, P. G., & Migliaccio, E. (2015) · Aging and Disease · doi:10.14336/ad.2014.0228 · Cited by 16
Metadata
- Authors
- Bartke, A., & Brown-Borg, H.
- Venue
- Current Topics in Developmental Biology
- Publisher
- Elsevier
- Published
- 2004
- Volume
- 63
- Pages
- 189-225
- ISSN
- 0070-2153 (ISSN-L)
- OpenAlex
- W1523543948
- Cited by
- 356
- References
- 13
- FWCI
- 32.49
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
