Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response
Abstract
Oxytocin and vasopressin are two neuropeptides that have been extensively studied for their systemic and physiological roles. Studies in rodents show that oxytocin and vasopressin play an opposite role in several behavioural and physiological tests for anxiety and fear. Their effects on single cell activity in the central amygdala (CeA) triggered a number of electrophysiological studies that allowed us to develop a model of their opposing effects. In our model, GABAergic neurons in the lateral part of the central amygdala are excited by oxytocin and project to the medial part where they inhibit neurons that can be excited by vasopressin. Besides oxytocin and vasopressin, the CeA expresses a large number of other neuropeptide receptors and the question arises if a similar model can apply to their actions. We here develop a hypothesis in which neuropeptides, through their effects on distinct populations in the CeA, affect specific projections and specific physiological expressions of the fear response. Our hypothesis may be of importance for the current interest in neuropeptide receptors as therapeutic targets for neuropsychiatric disorders.
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Zink and Meyer-Lindenberg (2012) found that vasopressin decreased amygdala to medial prefrontal connectivity in a group of healthy volunteers.
“Interestingly, Zink and Meyer-Lindenberg (2012) found that vasopressin, which is thought to have an effect opposite to OXT by enhancing fear and anxiety (Viviani and Stoop, 2008), decreased amygdala to medial prefrontal connectivity in group of healthy volunteers.”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Viviani and Stoop, 2008
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- Authors
- VIVIANI, D., & STOOP, R.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- STOOP, R
- ORCID
- STOOP, R
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 207-218
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1540425568
- Cited by
- 96
- References
- 105
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 17.41
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- oxytocin, vasopressin, fear response, emotional expression, central amygdala, GABAergic neurons, neuropeptide receptors, anxiety, neuropsychiatric disorders, therapeutic target
- MeSH terms
- Amygdala, Animals, Blood-Brain Barrier, Brain Stem, Emotions, Fear, gamma-Aminobutyric Acid, Humans, Neurons, Neuropeptides, Oxytocin, Photic Stimulation, Septal Nuclei, Vasopressins, Trust
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