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Cited by 100Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Coping with stress in rats and mice: Differential peptidergic modulation of the amygdala-lateral septum complex

Koolhaas, J.M., Everts, H., de Ruiter, A.J.H., de Boer, S.F., Bohus, B.·1999·Progress in Brain Research
DOI 10.1016/s0079-6123(08)61586-1
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Abstract

This chapter focuses on the parvicellular vasopressin (VP) system originating from the medial nucleus of the amygdala (MeA) and bed nucleus of the stria terminalis (BNST). The vasopressinergic fibers of these nuclei innervate a number of limbic brain areas including the septum-hippocampal complex. Interestingly, this VP system is sexually dimorphic and the VP synthesis in this system depends on circulating gonadal steroids. Studies in rats and mice show that the variation in the lateral septal VP network within the male gender is as large as the variation between the sexes as reported in the literature. Non-aggressive males are characterized by a far more extensive VP network and a higher VP content in the lateral septal area than aggressive males. A review of the literature on the function of lateral septal VP in the organization of behavior reveals not only a modulatory role of behavior in a social context, but also of fear- and anxiety-related behaviors. It is argued that these seemingly diverse functions might be explained by the concept of coping style. Extensive behavioral and physiological analyses in a variety of animal species show that males may be characterized by the way in which they cope with environmental challenges in general. Aggressive males tend to cope actively with their environment whereas non-aggressive males seem to accept the situation as it is more easily. In several tests, we determined the effects of chronic infusion of the V1 receptor antagonist l…

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  • Social defeat stress provides a potential means to investigate components of the basic neuropathology underlying affective illnesses, which is providing fundamentally new information about the molecular basis of affective disorders to aid in the development of novel antidepressant treatment strategies.

    “Thus, social defeat stress provides a potential means to investigate components of the basic neuropathology underlying affective illnesses8,33–36, which is providing fundamentally new information about the molecular basis of affective disorders to aid in the development of novel antidepressant treatment strategies20.”

    From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [35]

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Authors
Koolhaas, J. M., Everts, H., de Ruiter, A. J. H., de Boer, S. F., & Bohus, B.
Corresponding author
Koolhaas, J.M.
Venue
Progress in Brain Research
Publisher
Elsevier
Published
1999
Volume
119
Pages
437-448
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(08)61586-1
OpenAlex
W1522976403
Cited by
100
References
10
Citations by year
2025: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2019: 1 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
FWCI
15.01
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
stress coping, vasopressin, lateral septum, bed nucleus of the stria terminalis, medial amygdala, sex differences, aggression, sex steroids, V1 receptor antagonist, social behavior, social learning, anxiety, fear, individual differences
MeSH terms
Adaptation, Psychological, Aggression, Amygdala, Animals, Male, Septal Nuclei, Stress, Physiological, Vasopressins, Mice, Rats

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