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Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

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Lebrón, José A., Bennett, Melanie J., Vaughn, Daniel E., Chirino, Arthur J., Snow, Peter M., Mintier, Gabriel A., Feder, John N., Bjorkman, Pamela J.·1998·Cell

DOI 10.1016/s0092-8674(00)81151-4

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The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor 1 1Edited by I. A. Wilson
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“The exact functional effect of the H63D variant is as yet unclear, but some evidence suggests that it may alter an intramolecular salt bridge, possibly affecting the interaction of the HFE protein with the TfR [63].”
BackgroundInfluential
Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis
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Authors: Lebrón, J. A., Bennett, M. J., Vaughn, D. E., Chirino, A. J., Snow, P. M., Mintier, G. A., Feder, J. N., & Bjorkman, P. J.
Venue: Cell
Publisher: Elsevier BV
Published: 1998-04
Volume: 93
Issue: 1
Pages: 111-123
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)81151-4
OpenAlex: W2098058233
Cited by: 638
References: 3
FWCI: 36.17
Type: journal article
Language: en
Open access: bronze

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Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

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