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The intracellular trafficking pathway of transferrin
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Previous studies have revealed heterogeneity in recycling of different receptors: LDLR is transported along a RAB11-mediated slow recycling pathway involving the endocytic recycling compartment, while TFR utilizes both RAB11- and RAB4-mediated rapid recycling pathways.
“Previous studies have revealed heterogeneity in the recycling of different receptors, with some, including LDLR, transported along a RAB11-mediated slow recycling pathway involving the endocytic recycling compartment, while others, including TFR, utilize both RAB11- and RAB4-mediated rapid recycling pathways (20, 42, 43).”
From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [20]
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Experimental — accuracy not yet measuredTransferrin remains in complex with TFR until it is released to the extracellular environment after TFR is recycled back to the plasma membrane.
“transferrin remains in complex with TFR until it is released to the extracellular environment after TFR is recycled back to the plasma membrane (18, 20).”
From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [20]
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Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
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Transferrin receptor 2: a new molecule in iron metabolism
Trinder, D., & Baker, E. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00258-3 · Cited by 94 · cited 1×
“TfR2 is a close homologue of TfR1 showing 45% identity in the extracellular domain [3].”
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Metadata
- Authors
- Mayle, K. M., Le, A. M., & Kamei, D. T.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 1820
- Issue
- 3
- Pages
- 264-281
- ISSN
- 0304-4165
- PMC
- PMC3288267
- Cited by
- 466
- References
- 3
- Language
- en
- Funders
- NIH
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