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The intracellular trafficking pathway of transferrin

Mayle, Kristine M., Le, Alexander M., Kamei, Daniel T.·2012·Biochimica et Biophysica Acta (BBA) - General Subjects

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  • Previous studies have revealed heterogeneity in recycling of different receptors: LDLR is transported along a RAB11-mediated slow recycling pathway involving the endocytic recycling compartment, while TFR utilizes both RAB11- and RAB4-mediated rapid recycling pathways.

    “Previous studies have revealed heterogeneity in the recycling of different receptors, with some, including LDLR, transported along a RAB11-mediated slow recycling pathway involving the endocytic recycling compartment, while others, including TFR, utilize both RAB11- and RAB4-mediated rapid recycling pathways (20, 42, 43).”

    From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [20]

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  • Transferrin remains in complex with TFR until it is released to the extracellular environment after TFR is recycled back to the plasma membrane.

    “transferrin remains in complex with TFR until it is released to the extracellular environment after TFR is recycled back to the plasma membrane (18, 20).”

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Metadata

Authors
Mayle, K. M., Le, A. M., & Kamei, D. T.
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2012-03
Volume
1820
Issue
3
Pages
264-281
ISSN
0304-4165
Cited by
466
References
3
Language
en
Funders
NIH

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