Spatial Sensory Organization and Body Representation in Pain Perception

Haggard, Patrick; Iannetti, Gian Domenico; Longo, Matthew R.

doi:10.1016/j.cub.2013.01.047

Cited by 192Pain Mechanisms and TreatmentsPain Management and TreatmentTactile and Sensory Interactions

Spatial Sensory Organization and Body Representation in Pain Perception

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Haggard, Patrick, Iannetti, Gian Domenico, Longo, Matthew R.·2013·Current Biology

DOI 10.1016/j.cub.2013.01.047

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Abstract

Pain is a subjective experience that protects the body. This function implies a special relation between the brain mechanisms underlying pain perception and representation of the body. All sensory systems involve the body for the trivial reason that sensory receptors are located in the body. The nociceptive system of detecting noxious stimuli comprises two classes of peripheral afferents, Aδ and C nociceptors, that cover almost the entire body surface. We review evidence from experimental studies of pain in humans and other animals suggesting that Aδ skin nociceptors project to a spatially-organised, somatotopic map in the primary somatosensory cortex. While the relation between pain perception and homeostatic regulation of bodily systems is widely acknowledged, the organization of nociceptive information into spatial maps of the body has received little attention. Importantly, the somatotopic neural organization of pain systems can shed light on pain-related plasticity and pain modulation. Finally, we show that the neural coding of noxious stimuli, and consequent experience of pain, are both strongly influenced when cognitive representations of the body are activated by viewing the body, as opposed to viewing another object - an effect we term 'visual analgesia'. We argue that pain perception involves some of the representational properties of exteroceptive senses, such as vision and touch. Pain, however, has the unique feature that the content of representation is the body itself, rather than any external object of perception. We end with some suggestions regarding how linking pain to body representation could shed light on clinical conditions, notably chronic pain.

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Noxious stimuli are mapped on a spatial representation that is anchored to the PPS.
“In analogy to other sensory stimuli, it has been demonstrated that noxious stimuli are mapped on a spatial representation that is anchored to the PPS (Haggard et al. 2013; De Paepe et al. 2014).”
From Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition (2024) · cites this paper as Haggard et al. 2013
The Mapping of Pain Signals into External Space section (p. 8) reports evidence of spatiotopic effects on pain from a noxious laser stimulus, supporting a spatial component. But it says the evidence is limited, describes remapping as potentially imperfect, and treats integration within peripersonal space as a subject for further research—not as an established mapping anchored to peripersonal space. (LLM, conf=0.86)
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Authors: Haggard, P., Iannetti, G. D., & Longo, M. R.
Affiliations: University College London (GB)
Birkbeck, University of London (GB)
Corresponding author: Haggard, Patrick
ORCID: Haggard, Patrick
Iannetti, Gian Domenico
Longo, Matthew R.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2013-02
Volume: 23
Issue: 4
Pages: R164-R176
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2013.01.047
OpenAlex: W2012271414
Cited by: 192
References: 168
Citations by year: 2026: 3 · 2025: 13 · 2024: 13 · 2023: 16 · 2022: 10 · 2021: 10 · 2020: 11 · 2019: 21 · 2018: 16 · 2017: 12 · 2016: 19 · 2015: 20 · 2014: 21 · 2013: 6
FWCI: 2.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
BIROn (Birkbeck, University of London) (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: pain perception, representation of the body, somatotopic map, primary somatosensory cortex, C nociceptors, nociceptive system, pain modulation, body schema, chronic pain
MeSH terms: Afferent Pathways, Body Image, Brain, Humans, Mechanoreceptors, Nociceptors, Pain, Sensation, Somatosensory Cortex, Pain Perception, Nociception

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Spatial Sensory Organization and Body Representation in Pain Perception

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