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The burden and costs of chronic diseases in low-income and middle-income countries.
Abstract
This paper estimates the disease burden and loss of economic output associated with chronic diseases-mainly cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes-in 23 selected countries which account for around 80% of the total burden of chronic disease mortality in developing countries. In these 23 selected low-income and middle-income countries, chronic diseases were responsible for 50% of the total disease burden in 2005. For 15 of the selected countries where death registration data are available, the estimated age-standardised death rates for chronic diseases in 2005 were 54% higher for men and 86% higher for women than those for men and women in high-income countries. If nothing is done to reduce the risk of chronic diseases, an estimated US$84 billion of economic production will be lost from heart disease, stroke, and diabetes alone in these 23 countries between 2006 and 2015. Achievement of a global goal for chronic disease prevention and control-an additional 2% yearly reduction in chronic disease death rates over the next 10 years-would avert 24 million deaths in these countries, and would save an estimated $8 billion, which is almost 10% of the projected loss in national income over the next 10 years.
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“Epidemiological transitions are defined by a shift from a heavy burden of infectious diseases to a major prevalence of noncommunicable diseases (NCDs)”
From Colonial transition as a major mediator of global health transition: lessons from the 2024 New Caledonia crisis (2025) · cites this paper as [3]
In the citing paper
“which currently account for about 80% of all deaths worldwide”
From Colonial transition as a major mediator of global health transition: lessons from the 2024 New Caledonia crisis (2025) · cites this paper as [3]
In the citing paper
“and are thus closely connected to the ageing of the populations – i.e. the demographic transition [3]”
From Colonial transition as a major mediator of global health transition: lessons from the 2024 New Caledonia crisis (2025) · cites this paper as [3]
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“The expenditure ratios reported here imply, as do analyses using different methods, [37,38] that in LMICs the economic burden of DM may constrain the availability of medical resources for other health conditions and retard national economic growth in future years.”
Amiri, M., Majid, H. A., Hairi, F. M., Thangiah, N., Bulgiba, A. M., & Su, T. T. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-s3-s3 · Cited by 90
“It is proven that socioeconomic status (SES) influences the health condition [17-19].”
BackgroundPrevalence of Chronic Disease and Insurance Coverage among Refugees in the United States
Yun, K., Fuentes‐Afflick, E., & Desai, M. M. (2012) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-012-9618-2 · Cited by 92
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“CMRF show an escalating trend in most developing countries and are becoming leading contributors to the burden of diseases, death and disability((6,7)).”
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“Background Diabetes mellitus (DM) appears to be a global epidemic and increasingly a major non-communicable disease threatening both affluent and non-affluent society [1, 2].”
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“Among the NCD, obesity and psychiatric disorders emerge as health challenges for the next decades [2–4]; these two conditions are priorities in the public health agenda [5–8], due to their disabling effects on the individuals’ quality of life, reduced labor ability, higher use of health services, and societal costs [7…”
BackgroundEffects of Psychological Stress on Hypertension in Middle-Aged Chinese: A Cross-Sectional Study
Hu, B., Liu, X., Yin, S., Fan, H., Feng, F., & Yuan, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129163 · Cited by 88
“Non-communicable cardiovascular diseases (CVDs) are predicted to be the leading cause of death and disability globally by 2020 [1].”
BackgroundThe Prevention of Lifestyle-Related Chronic Diseases
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Advocacy for outpatient cardiac rehabilitation globally
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“In low and middle-income countries, the burden of CVD is of epidemic proportions [41, 42].”
BackgroundMethodInfluentialImpact of school policies on non-communicable disease risk factors – a systematic review
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“More than 80% of deaths from chronic disease now occur in low and middle-income countries, [1,2] and they represent a substantial burden for individuals, families, and national economies [3].”
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“40 per person per year in LMICs.(18) A few other interventions (“good buys”) could deliver substantial additional health gains (e.”
BackgroundMahmudiono, T., Segalita, C., & Rosenkranz, R. R. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193730 · Cited by 85
“In fact, NCDs account for 80% of the total burden of disease mortality in developing countries; it is estimated that economic production of $84 billion in USD will be lost from heart disease, stroke, and diabetes alone [100].”
BackgroundPeritoneal dialysis—current status and future challenges
Davies, S. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.100 · Cited by 85
The challenge of polypharmacy in cardiovascular medicine
Volpe, M., Chin, D., & Paneni, F. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00757.x · Cited by 88
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A Systematic Review on the Contributions of Edible Plant and Animal Biodiversity to Human Diets
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“In addition, one hundred million of disability adjusted life years are attributed to diet-related chronic Published online: September 23, 2011 Correspondence to: Patrick Kolsteren, e-mail: Patrick.Kolsteren@ugent.be diseases such as cardiovascular diseases and diabetes (Abegunde et al. 2007).”
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The epidemiology of obesity in reproduction
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Factors Affecting Health-Promoting Behaviors of University Students in Jordan
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“In addition to that, non-communicable diseases are responsible for the loss of economic output in developing countries, an estimated US$ 84 billion of economic production will be lost between 2006 and 2015 if no action taken to reduce the risk of non-communicable diseases [9].”
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“Low- and middleincome countries (LMIC) are disproportionally affected: over 80% of cardiovascular disease (CVD) deaths occur in LMIC, and almost half of CVD deaths are in people younger than 70 years in these countries (2).”
BackgroundHypothetical Midlife Interventions in Women and Risk of Type 2 Diabetes
Danaei, G., Pan, A., Hu, F. B., & Hernán, M. Á. (2012) · Epidemiology · doi:10.1097/ede.0b013e318276c98a · Cited by 85
“com © 2012 Lippincott Williams & Wilkins the parametric models; (3) “intervene” by setting the values of some covariates to values determined by the hypothetical interventions; (4) estimate the predicted probability of the outcome using these new values; (5) repeat steps 2 through 4 for the entire duration of follow-u…”
MethodRecent Advances in Preventive Cardiology and Lifestyle Medicine
Franklin, B. A., & Cushman, M. (2011) · Circulation · doi:10.1161/circulationaha.110.981613 · Cited by 82
Mahmudiono, T., Nindya, T. S., Andrias, D. R., Megatsari, H., & Rosenkranz, R. R. (2018) · Nutrients · doi:10.3390/nu10050535 · Cited by 81
“The present amount of NCDs accounts for 80% of the total burden of disease mortality in developing countries; an estimated US $84 billion of economic production will be lost from heart disease, stroke, and diabetes alone [11].”
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“Evidence suggests that chronic and disabling conditions among the mature adult population, resulting from the cumulative effects of poor nutrition and frequent exposure to infectious disease, lead to significant levels of functional limitations in day-to-day activities and a substantial gap between potential and actua…”
BackgroundPatterns and Associated Factors of Physical Activity among Adolescents in Nigeria
Oyeyemi, A. L., Ishaku, C. M., Oyekola, J., Wakawa, H. D., Lawan, A., Yakubu, S., & Oyeyemi, A. Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150142 · Cited by 88
Metadata
- Authors
- Abegunde, D. O., Mathers, C. D., Adam, T., Ortegon, M., & Strong, K.
- Affiliations
- World Health Organization (CH)
- Corresponding author
- Mathers, Colin D
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 370
- Issue
- 9603
- Pages
- 1929-1938
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1987313755
- Cited by
- 1,603
- References
- 45
- Citations by year
- 2026: 24 · 2025: 44 · 2024: 62 · 2023: 58 · 2022: 87 · 2021: 68 · 2020: 123 · 2019: 104 · 2018: 98 · 2017: 113 · 2016: 111 · 2015: 106 · 2014: 115 · 2013: 106 · 2012: 96
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Epidemiology
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Global Health Care Issues
- Keywords
- chronic disease, disease burden, economic cost of illness, cardiovascular disease, cancer, chronic respiratory disease, diabetes mellitus, low-income countries, middle-income countries, sex differences in mortality, mortality averted, chronic disease prevention, global health goals
- MeSH terms
- Chronic Disease, Developing Countries, Female, Humans, Life Expectancy, Male, Registries, Global Health, Cost of Illness, Age Distribution, Sex Distribution
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