Assessing the effects of bupropion SR on mood dimensions of depression

Tomarken, Andrew J.; Dichter, Gabriel S.; Freid, Cathryn; Addington, Stephanie; Shelton, Richard C.

doi:10.1016/s0165-0327(02)00306-3

Cited by 139Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

Assessing the effects of bupropion SR on mood dimensions of depression

Tomarken, Andrew J., Dichter, Gabriel S., Freid, Cathryn, Addington, Stephanie, Shelton, Richard C.·2004·Journal of Affective Disorders

DOI 10.1016/s0165-0327(02)00306-3

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Abstract

Background We assessed the therapeutic effects of bupropion SR and placebo on mood and anxiety symptoms derived from the tripartite model of mood. Based on evidence indicating linkages between dopaminergic activity and the emotional dimension of positive affect/anhedonia, we hypothesized that the dopaminergic effects of bupropion SR would yield particularly pronounced effects on symptoms of anhedonia, relative to anxiety.Methods Nineteen depressed outpatients were randomly assigned to treatment with either bupropion SR 300 mg/day or placebo during a 6-week initial treatment phase. This was followed by a second open-label phase in which patients previously treated with bupropion SR had their dose increased to 400 mg/day, and the placebo group was initiated on bupropion SR 300 mg/day.Results Random regression analyses revealed that during the initial double-blind phase, bupropion SR elicited greater declines than placebo on all measures except those that assessed anxiety. By contrast, the weakest placebo effects were evident on anhedonia. Items assessing the low positive affect pole of the anhedonia dimension were more sensitive to earlier/lower dose bupropion SR treatment, whereas items assessing the high positive affect pole were more sensitive to later/higher dose bupropion SR treatment.Limitations Replication and extension using a larger sample size are mandated.Conclusions This study suggests that the catecholaminergic effects of bupropion SR tended to produce more robust effects on anhedonia/positive affect than placebo.

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Although both DA and non-DA agents can effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia compared with non-DA agents.
“Particularly relevant in the present context are previous reports [290,296,297] that although both DA and non-DA agents can be used to effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia, specifically when compared with non-DA agents [19,298-300].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [300]

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Authors: Tomarken, A. J., Dichter, G. S., Freid, C., Addington, S., & Shelton, R. C.
Affiliations: Vanderbilt University (US)
Vanderbilt University Medical Center (US)
Corresponding author: Tomarken, Andrew J.
ORCID: Tomarken, Andrew J.
Dichter, Gabriel S.
Shelton, Richard C.
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2004-03
Volume: 78
Issue: 3
Pages: 235-241
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/s0165-0327(02)00306-3
OpenAlex: W2165226337
Cited by: 139
References: 29
Citations by year: 2026: 3 · 2025: 11 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 48 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 4
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-01741, K24MH001741)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: bupropion sustained release, depression, anhedonia, positive affect, anxiety symptoms, dopaminergic effects, placebo effect, dose-response relationship, outpatients
MeSH terms: Administration, Oral, Adult, Affect, Depression, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Bupropion, Treatment Outcome, Antidepressive Agents, Second-Generation

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Assessing the effects of bupropion SR on mood dimensions of depression

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