Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats

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Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways

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The impact of environmental enrichment in laboratory rats—Behavioural and neurochemical aspects

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Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

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Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

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Environmental enrichment and the brain

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Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice

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Effects of Environmental Enrichment at Ages 3–5 Years on Schizotypal Personality and Antisocial Behavior at Ages 17 and 23 Years

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Partial reversal of the effect of maternal care on cognitive function through environmental enrichment

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The influences of environmental enrichment, cognitive enhancement, and physical exercise on brain development: Can we alter the developmental trajectory of ADHD?

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Psychological stress and environmental adaptation in enriched vs. impoverished housed rats

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Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression

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Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

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Adolescent enrichment partially reverses the social isolation syndrome

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Environmental influences on brain neurotrophins in rats

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Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

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Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study

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Requirement of adult-born neurons for hippocampus-dependent learning

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Early-life handling stimulation and environmental enrichment

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Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia

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Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner

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Why is music therapeutic for neurological disorders? The Therapeutic Music Capacities Model

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Age-related deficits as working memory load increases: relationships with growth factors

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Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

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Epigenetic control of neurobehavioural plasticity: the role of neurotrophins

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Reviews: Mechanisms Mediating Brain Plasticity: IGF1 and Adult Hippocampal Neurogenesis

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Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice: social versus physical enrichment

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Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation

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The Effect of Enriched Environment on the Outcome of Traumatic Brain Injury; A Behavioral, Proteomics, and Histological Study

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Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats

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Environmental enrichment enhances spatial cognition in rats by reducing thigmotaxis (wall hugging) during testing

Harris, A. P., D’Eath, R. B., & Healy, S. D. (2009) · Animal Behaviour · doi:10.1016/j.anbehav.2009.02.019 · Cited by 102

Environmental enrichment effects in social investigation in rats are gender dependent

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Combined pre- and postnatal environmental enrichment programs the HPA axis differentially in male and female rats

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Sex differences in object location memory and spatial navigation in Long-Evans rats

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Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner

Bakoš, J., Hlaváčová, N., Rajman, M., Ondičová, K., Koros, C., Kitraki, E., Steinbusch, H. W. M., & Ježová, D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.054 · Cited by 96

Transformation of cortical and hippocampal neural circuit by environmental enrichment

Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 96

Huntington’s Disease

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Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour

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Broad activation of the olfactory bulb produces long-lasting changes in odor perception

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A “deficient environment” in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus

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Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment

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Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats

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Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats

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Voluntary exercise influences behavioral development in rats exposed to alcohol during the neonatal brain growth spurt.

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Predicting long-term outcome following traumatic brain injury (TBI)

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Spatio‐temporal activation of cyclic AMP response element‐binding protein, activity‐regulated cytoskeletal‐associated protein and brain‐derived nerve growth factor: a mechanism for pontine‐wave generator activation‐dependent two‐way active‐avoidance memory processing in the rat

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Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice

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Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding

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Elevation of Nerve Growth Factor and Antisense Knockdown of TrkA Receptor during Contextual Memory Consolidation

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The Interaction between Psychological Health and Traumatic Brain Injury: A Neuroscience perspective

Hoffman, S. W., & Harrison, C. R. (2009) · The Clinical Neuropsychologist · doi:10.1080/13854040903369433 · Cited by 65

Selective Nicotinic Receptor Consequences in APPSWE Transgenic Mice

Bednar, I., Paterson, D., Marutle, A., Pham, T. M., Svedberg, M. M., Hellström‐Lindahl, E., Mousavi, M. T., COURT, J. A., Morris, C. M., Perry, E. K., et al. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1112 · Cited by 65

Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairmentPreprint

Hellweg, R., Lohmann, P., Huber, R., Kühl, A., & Riepe, M. W. (2006) · Learning & Memory · doi:10.1101/lm.2606 · Cited by 64

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study

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Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice

Zhu, S., Codita, A., Bogdanović, N., Hjerling‐Leffler, J., Ernfors, P., Winblad, B. G., Dickins, D. W., & Mohammed, A. H. S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.032 · Cited by 58

Effects of Enriched Physical and Social Environments on Motor Performance, Associative Learning, and Hippocampal Neurogenesis in Mice

Madroñal, N., López-Aracil, C., Rangel, A., del Rı́o, J. A., Delgado-Garcia, J. M., & Gruart, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011130 · Cited by 62

Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats

Holguin, S., Huang, Y., Liu, J., & Wurtman, R. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.042 · Cited by 57

Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

Dhanushkodi, A., & Shetty, A. K. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.004 · Cited by 56

Tactile stimulation and maternal separation prevent hippocampal damage in rats submitted to neonatal hypoxia–ischemia

Rodrigues, A. L., Arteni, N. S., Abel, C. R., Zylbersztejn, D. S., Chazan, R., Viola, G. G., Xavier, L. L., Achaval, M., & Netto, C. A. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.020 · Cited by 54

Environmental change during postnatal development alters behaviour, cognitions and neurogenesis of mice

Iso, H., Shimoda, S., & Matsuyama, T. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.025 · Cited by 52

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

Liew, A. K. Y., Teo, C. H., & Soga, T. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03016-w · Cited by 61

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan

Fréret, T., Billard, J., Schumann‐Bard, P., Dutar, P., Dauphin, F., Boulouard, M., & Bouët, V. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.028 · Cited by 52

Behavioral/Environmental Intervention Improves Learning After Cerebral Hypoxia-Ischemia in Rats

Chou, I., Trakht, T., Signori, C., Smith, J., Felt, B. T., Vázquez, D. M., & Barks, J. (2001) · Stroke · doi:10.1161/hs0901.095656 · Cited by 51

Alzheimer’s Disease, Neural Plasticity, and Functional Recovery

Mercerón‐Martínez, D., Ibaceta-González, C., Salazar, C., Almaguer‐Melian, W., Bergado, J. A., & Palacios, A. G. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201178 · Cited by 48

Influence of environmental enrichment on steady-state mRNA levels for EAAC1, AMPA1 and NMDA2A receptor subunits in rat hippocampus

Andin, J., Hallbeck, M., Mohammed, A. H. S., & Marcusson, J. O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.101 · Cited by 48

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring

Sparling, J. E., Baker, S. L., & Bielajew, C. H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.033 · Cited by 47

Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice

Need, A. C., & Giese, K.-P. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00020.x · Cited by 47

Exposure to enriched environment improves spatial learning performances and enhances cell density but not choline acetyltransferase activity in the hippocampus of ventral subicular-lesioned rats.

Dhanushkodi, A., Bindu, B., Raju, T. R., & Kutty, B. M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.491 · Cited by 44

System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment

Bonaccorsi, J., Cintoli, S., Mastrogiacomo, R., Baldanzi, S., Braschi, C., Pizzorusso, T., Cenni, M. C., & Berardi, N. (2013) · Neural Plasticity · doi:10.1155/2013/956312 · Cited by 45

Electroconvulsive stimuli alter nerve growth factor but not brain-derived neurotrophic factor concentrations in brains of a rat model of depression

Angelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A. (2003) · Neuropeptides · doi:10.1016/s0143-4179(03)00004-0 · Cited by 42

Effects of cafeteria diet and high fat diet intake on anxiety, learning and memory in adult male rats

Pini, R. T. B., do Vales, L. D. M. F., Costa, T. M. B., & Almeida, S. S. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1149294 · Cited by 40

Environmental enrichment and its influence on rodent offspring and maternal behaviours, a scoping style review of indices of depression and anxiety

Sparling, J. E., Barbeau, K., Boileau, K., & Konkle, A. T. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172997 · Cited by 42

Enriched environment exposure alters the input-output dynamics of synaptic transmission in area CA1 of freely moving rats

Irvine, G. I., & Abraham, W. C. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.031 · Cited by 40

The impact of environmental and social factors on learning abilities: a meta‐analysis

Lambert, C. T., & Guillette, L. M. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12783 · Cited by 45

Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats

Bindu, B., Jagadapillai, R., & Kutty, B. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.044 · Cited by 37

Early environmental therapy rescues brain development in a mouse model of Down syndrome

Begenisic, T., Sansevero, G., Baroncelli, L., Cioni, G., & Sale, A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.014 · Cited by 35

The effects of gestational and postpartum environmental enrichment on the mother rat: A preliminary investigation

Sparling, J. E., Mahoney, M. M., Baker, S., & Bielajew, C. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.041 · Cited by 35

Early environmental cues affect object recognition memory in adult female but not male C57BL/6 mice

Coutellier, L. D., & Würbel, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.001 · Cited by 34

Influence of environmental enrichment on an object recognition task in CF1 mice

Viola, G. G., Botton, P. H. S., Moreira, J. D., Ardais, A. P., Oses, J. P., & Souza, D. O. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.10.003 · Cited by 34

The role of cognitive activity in cognition protection: from Bedside to Bench

Li, B., Wang, Y., Tang, H., & Chen, S. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0078-4 · Cited by 34

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

O’Connor, A. M., Burton, T. J., Leamey, C. A., & Sawatari, A. (2014) · Journal of Visualized Experiments · doi:10.3791/52225 · Cited by 30

Early experience and domestication affect auditory discrimination learning, open field behaviour and brain size in wild Mongolian gerbils and domesticated Laboratory gerbils (Meriones unguiculatus forma domestica)

Stuermer, I. W., & Wetzel, W. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.025 · Cited by 30

Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood

Aghaie, C. I., Hausknecht, K. A., Wang, R., Dezfuli, P. H., Haj‐Dahmane, S., Kane, C. J. M., Sigurdson, W. J., & Shen, R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14275 · Cited by 30

Sleeping Together

Donlea, J. M., & Shaw, P. J. (2009) · Advances in genetics · doi:10.1016/s0065-2660(09)68003-2 · Cited by 30

Early environment contributes to developmental disruption of MPFC after neonatal ventral hippocampal lesions in rats

Wood, G. K., Quirion, R., & Srivastava, L. K. (2003) · Synapse · doi:10.1002/syn.10265 · Cited by 31

Impact of Dementia‐derived Nonpharmacological Intervention Procedures on Cognition and Behavior in Older Adults With Intellectual Disabilities: A 3‐year Follow‐up Study

Vreese, L. P. D., Mantesso, U., Bastiani, E. D., Weger, E., Marangoni, A., & Gomiero, T. (2012) · Journal of Policy and Practice in Intellectual Disabilities · doi:10.1111/j.1741-1130.2012.00344.x · Cited by 28

Exposure to a broad range of odorants decreases cell mortality in the olfactory bulb

Woo, C. C., Hingco, E. E., Taylor, G. E., & Leon, M. (2006) · Neuroreport · doi:10.1097/01.wnr.0000215780.84226.2d · Cited by 28

Modest environmental enrichment: Effect on a radial maze validation and well being of rats

Brillaud, E., Morillion, D., & de Sèze, R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.069 · Cited by 28

Neonatal Handling Impairs Spatial Memory and Leads to Altered Nitric Oxide Production and DNA Breaks in A Sex Specific Manner

Noschang, C. G., Krolow, R., Fontella, F. U., Arcego, D. M., Diehl, L. A., Weis, S. N., Arteni, N. S., & Dalmaz, C. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0158-7 · Cited by 27

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

Wang, R., Hausknecht, K. A., Shen, Y.-L., Haj‐Dahmane, S., Vezina, P., & Shen, R. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.07.013 · Cited by 27

Enriched Environment and White Matter in Aging Brain

Yang, S., Lü, W., Zhou, D., & Tang, Y. C. (2012) · The Anatomical Record · doi:10.1002/ar.22526 · Cited by 28

Abilities in tactile discrimination of textures in adult rats exposed to enriched or impoverished environments

Bourgeon, S., Xerri, C., & Coq, J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.002 · Cited by 26

Effects of Postnatal Cocaine Exposure and Environmental Enrichment on Rat Behavior in a Forced Swim Test

Magalhães, A., Summavielle, T., Ferreira, M. A., & de Sousa, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.077 · Cited by 24

Tactile stimulation and neonatal isolation affect behavior and oxidative status linked to cocaine administration in young rats

Antoniazzi, C. T. D. D., Boufleur, N., Pase, C. S., Kuhn, F. T., Dias, V. T., Segat, H. J., Roversi, K., Roversi, K., Benvegnú, D. M., & Bürger, M. E. (2014) · Behavioural Processes · doi:10.1016/j.beproc.2014.01.011 · Cited by 26

Effect of early life housing manipulation on baseline and drug-induced behavioural responses on neurochemistry in the male rat

Simpson, J., Bree, D., & Kelly, J. P. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.008 · Cited by 23

Effects of neonatal handling and enriched environment on neurotrophins and cognitive function

Pham, T. M. (2000) · Figshare

Environmental influence on behaviour and nerve growth factor in the brain

Mohammed, A. K., Winblad, B. G., Ebendal, T., & Lärkfors, L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90195-h · Cited by 169

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

Pham, T. M., Ickes, B. R., Albeck, D. S., Söderström, S., Granholm, A.-C., & Mohammed, A. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00316-4 · Cited by 265

Environmental enrichment increases NGF levels in hippocampus and visual cortex and improves spatial learning in elderly rats

Pham, T., Söderström, S., Bogdanović, N., Henriksson, B. G., Winblad, B. G., & Mohammed, A. H. (1997) · Acta Neurobiologiae Experimentalis · Cited by 1

Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner

Birch, A. M., McGarry, N., & Kelly, A. M. (2013) · Hippocampus · doi:10.1002/hipo.22103 · Cited by 161