The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers Evidence for Monoaminergic Mechanisms
Abstract
We used a novel computerized decision-making task to compare the decision-making behavior of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions of orbital prefrontal cortex (PFC) or dorsolateral/medial PFC. We also assessed the effects of reducing central 5-hydroxytryptamine (5-HT) activity using a tryptophan-depleting amino acid drink in normal volunteers. Chronic amphetamine abusers showed suboptimal decisions (correlated with years of abuse), and deliberated for significantly longer before making their choices. The opiate abusers exhibited only the second of these behavioral changes. Importantly, both sub-optimal choices and increased deliberation times were evident in the patients with damage to orbitofrontal PFC but not other sectors of PFC. Qualitatively, the performance of the subjects with lowered plasma tryptophan was similar to that associated with amphetamine abuse, consistent with recent reports of depleted 5-HT in the orbital regions of PFC of methamphetamine abusers. Overall, these data suggest that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC. These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections.
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“Experimental studies of ventromedial patients have identified core deficits in reward and punishment guided decision making (Bechara et al., 1994;Rogers et al., 1999;Clark et al., 2008, Moretti et al., 2009)”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Rogers et al., 1999
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Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · cited 3×
“…Bechara and colleagues have now demonstrated a consistent deficit in the decision-making cognition of patients with ventromedial PFC lesions, a deficit that is essentially absent in patients with dorsolateral or dorsomedial PFC damage (Bechara et al. 1994, 1996, 1998; see Damasio 1996 for review).”
BackgroundNeurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,108
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
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McLean, A., Rubinsztein, J. S., Robbins, T. W., & Sahakian, B. J. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1586-8 · Cited by 125
Reward-Related Decision-Making Deficits and Elevated Impulsivity Among MDMA and Other Drug Users
Hanson, K. L., Luciana, M., & Sullwold, K. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.02.003 · Cited by 125
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Dekkers, T. J., Popma, A., Agelink van Rentergem, J. A., Bexkens, A., & Huizenga, H. M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.03.001 · Cited by 119
Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14140 · Cited by 118
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TAVARES, J. V. T., DREVETS, W. C., & SAHAKIAN, B. J. (2003) · Psychological Medicine · doi:10.1017/s0033291703008432 · Cited by 113
Psychiatric diagnoses and personality traits associated with disadvantageous decision-making
Jollant, F., Guillaume, S., Jaussent, I., Bellivier, F., Leboyer, M., Castelnau, D., Malafosse, A., & Courtet, P. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.06.001 · Cited by 106
Roiser, J. P., McLean, A., Ogilvie, A. D., Blackwell, A. D., Bamber, D. J., Goodyer, I., Jones, P. B., & Sahakian, B. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300659 · Cited by 96
Winstanley, C. A., Zeeb, F. D., Bedard, A., Fu, K., Lai, B., Steele, C., & Wong, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.044 · Cited by 84
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Patel, D. D., Laws, K. R., Padhi, A., Farrow, J. M., Mukhopadhaya, K., Krishnaiah, R., & Fineberg, N. A. (2010) · Psychological Medicine · doi:10.1017/s0033291709991255 · Cited by 82
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82
Roiser, J. P., Levy, J., Fromm, S. J., Wang, H., Hasler, G., Sahakian, B. J., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301581 · Cited by 80
Cognitive deficits of executive functions and decision‐making in obsessive‐compulsive disorder
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Gaznick, N., Tranel, D., McNutt, A., & Bechara, A. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt172 · Cited by 72
Ferland, J. N., & Winstanley, C. A. (2017) · Addiction Biology · doi:10.1111/adb.12388 · Cited by 72
No fear no risk! Human risk behavior is affected by chemosensory anxiety signals
Haegler, K., Zernecke, R., Kleemann, A. M., Albrecht, J., Pollatos, O., Brückmann, H., & Wiesmann, M. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.09.019 · Cited by 65
Inactivating anterior insular cortex reduces risk taking
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Krmpotich, T., Mikulich-Gilbertson, S., Sakai, J., Thompson, L., Banich, M. T., & Tanabe, J. (2015) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000129 · Cited by 61
Duarte, N. A., Woods, S. P., Rooney, A., Atkinson, J. H., & Grant, I. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.006 · Cited by 56
The developmental psychopathology of motivation in adolescence
Fairchild, G. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.009 · Cited by 53
Dopaminergic Circuitry and Risk/Reward Decision Making: Implications for Schizophrenia
Stopper, C. M., & Floresco, S. B. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu165 · Cited by 51
Szmulewicz, A., Samamé, C., Caravotta, P., Martino, D. J., Igoa, A., Hidalgo-Mazzei, D., Colom, F., & Strejilevich, S. A. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-016-0047-3 · Cited by 28
Metadata
- Authors
- Rogers, R.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Rogers, R
- ORCID
- Rogers, R
- Venue
- Neuropsychopharmacology
- Published
- 1999-04
- Volume
- 20
- Issue
- 4
- Pages
- 322-339
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2132469266
- Cited by
- 1,101
- References
- 71
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 28 · 2023: 31 · 2022: 25 · 2021: 35 · 2020: 69 · 2019: 30 · 2018: 31 · 2017: 25 · 2016: 42 · 2015: 31 · 2014: 40 · 2013: 50 · 2012: 49
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- decision-making deficits, orbitofrontal cortex, prefrontal cortex lesions, tryptophan depletion, serotonin, dopamine, deliberation time, suboptimal choice, monoaminergic mechanisms, substance use disorders
- MeSH terms
- Adult, Brain Chemistry, Cognition, Decision Making, Female, Humans, Male, Middle Aged, Opioid-Related Disorders, Serotonin, Time Factors, Tryptophan, Biogenic Monoamines, Prefrontal Cortex, Amphetamine-Related Disorders, Risk Adjustment
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