Hypertension in Obesity and the Impact of Weight Loss
Open accessAbstract
Purpose of review Several interrelated mechanisms promote the development of hypertension in obesity, often contributing to end organ damage including cardiovascular disease and chronic kidney disease.Recent findings The treatment of hypertension in obesity is complicated by a high prevalence of resistant hypertension, as well as unpredictable hemodynamic effects of many medications. Weight loss stabilizes neurohormonal activity and causes clinically significant reductions in blood pressure. While lifestyle interventions can improve blood pressure, they fail to consistently yield sustained weight loss and have not demonstrated long-term benefits. Bariatric surgery provides more permanent weight reduction, corresponding with dramatic declines in blood pressure and attenuation of long-term cardiovascular risk. Hypertension is closely linked to the prevalence, pathophysiology, and morbidity of obesity. There are multiple barriers to managing hypertension in obesity. Surgical weight loss offers the most promise in reducing blood pressure and decreasing end organ damage in this patient population.
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- Authors
- Cohen, J. B.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- Corresponding author
- Cohen, Jordana B.
- ORCID
- Cohen, Jordana B.
- Venue
- Current Cardiology Reports
- Published
- 2017-08-24
- Volume
- 19
- Issue
- 10
- Pages
- 98-98
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- PMC
- PMC5606235
- OpenAlex
- W2747205886
- Cited by
- 147
- References
- 91
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 11 · 2023: 31 · 2022: 29 · 2021: 20 · 2020: 20 · 2019: 12 · 2018: 4
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Cardiology Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL133843)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- hypertension, obesity, weight loss, resistant hypertension, bariatric surgery, lifestyle intervention, blood pressure reduction, cardiovascular risk, chronic kidney disease, target organ damage
- MeSH terms
- Cardiovascular Diseases, Humans, Hypertension, Obesity, Risk Factors, Weight Loss, Bariatric Surgery, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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