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Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Open accessAbstract
alpha-Synuclein (alpha-Syn) is a 14 kDa protein of unknown function that has been implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain architecture, and possess a normal complement of dopaminergic cell bodies, fibers, and synapses. Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA) discharge and reuptake in response to simple electrical stimulation. However, they exhibit an increased release with paired stimuli that can be mimicked by elevated Ca2+. Concurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an attenuation of DA-dependent locomotor response to amphetamine. These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission.
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“However, αSyn-KO, and α/β-Syn double-KO mice exhibited reduced brain dopamine levels compared to wild-type (wt) animals”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [155]
Citations
Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 2,868
Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., & Aronin, N. (1997) · Science · doi:10.1126/science.277.5334.1990 · Cited by 2,439
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
Maroteaux, L., Campanelli, J., & Scheller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02804.1988 · Cited by 1,646
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
Davidson, W. S., Jonas, A., Clayton, D. F., & George, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9443 · Cited by 1,622
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., & Lansbury, P. T. (1996) · Biochemistry · doi:10.1021/bi961799n · Cited by 1,524
Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,520
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J. D. M., Ihara, Y., & Saitoh, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11282 · Cited by 1,502
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346
Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., & Saitoh, T. (1995) · Neuron · doi:10.1016/0896-6273(95)90302-x · Cited by 1,316
Renal and neuronal abnormalities in mice lacking GDNF
Moore, M. W., Klein, R. D., Fariñas, I., Sauer, H., Armanini, M. P., PHILLIPS, H. S., Reichardt, L. F., Ryan, A. M., Carver-Moore, K., & Rosenthal, A. (1996) · Nature · doi:10.1038/382076a0 · Cited by 1,268
Self-citationIdentification of two distinct synucleins from human brain
Jakes, R., Spillantini, M. G., & Goedert, M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00395-5 · Cited by 1,080
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Hong, M., Zhukareva, V., Vogelsberg-Ragaglia, V., Wszolek, Z., Reed, L., Miller, B., Geschwind, D., Bird, T., McKeel, D., Goate, A., et al. (1998) · Science · doi:10.1126/science.282.5395.1914 · Cited by 1,024
George, J. M., Jin, H., Woods, W. S., & Clayton, D. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90040-3 · Cited by 844
Amphetamine: Effects on Catecholamine Systems and Behavior
Seiden, L. S., Sabol, K. E., & Ricaurte, G. A. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.003231 · Cited by 827
Clayton, D. F., & George, J. M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01213-7 · Cited by 793
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Self-citationMechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
Jones, S. R., Gainetdinov, R. R., Wightman, R. M., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-01979.1998 · Cited by 626
High-frequency firing helps replenish the readily releasable pool of synaptic vesicles
Wang, L., & Kaczmarek, L. K. (1998) · Nature · doi:10.1038/28645 · Cited by 615
α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
Ostrerova, N., Petrucelli, L., Farrer, M. J., Mehta, N., Choi, P., Hardy, J., & Wolozin, B. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05782.1999 · Cited by 560
Pathologic conformations of prion proteins.
Cohen, F., & Prusiner, S. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.793 · Cited by 533
Jenco, J. M., Rawlingson, A., Daniels, B., & Morris, A. J. (1998) · Biochemistry · doi:10.1021/bi972776r · Cited by 431
Dittman, J. S., & Regehr, W. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06147.1998 · Cited by 410
Stevens, C. F., & Tsujimoto, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.846 · Cited by 368
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
Castillo, P. E., Janz, R., Sdhof, T. C., Tzounopoulos, T., Malenka, R. C., & Nicoll, R. A. (1997) · Nature · doi:10.1038/41574 · Cited by 356
Self-citationFon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N. P., Sulzer, D., & Edwards, R. H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80418-3 · Cited by 339
Self-citationNeurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
Horger, B. A., Nishimura, M. C., Armanini, M. P., Wang, L.-C., Poulsen, K. T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., et al. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04929.1998 · Cited by 338
Self-citationThe rat brain synucleins; family of proteins transiently associated with neuronal membrane
Maroteaux, L., & Scheller, R. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90043-w · Cited by 334
Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake
Wightman, R. M., & Zimmerman, J. B. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90015-g · Cited by 328
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327
Stevens, C., & Wesseling, J. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80550-4 · Cited by 327
The Synuclein FamilyPreprint
Lavedan, C. N. (1998) · Genome Research · doi:10.1101/gr.8.9.871 · Cited by 323
Hynes, M., Poulsen, K., Tessier‐Lavigne, M., & Rosenthal, A. (1995) · Cell · doi:10.1016/0092-8674(95)90454-9 · Cited by 226
Self-citationRebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 187
Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?
Mezey, É., Dehejia, A. M., Harta, G., Papp, M. I., Polymeropoulos, M. H., & Brownstein, M. (1998) · Nature Medicine · doi:10.1038/nm0798-755 · Cited by 185
Schlüter, O. M., Schnell, E., Verhage, M., Tzonopoulos, T., Nicoll, R. A., Janz, R., Malenka, R. C., Geppert, M., & Südhof, T. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05834.1999 · Cited by 172
Buchman, V. L., Hunter, H. J. A., Piñón, L. G. P., Thompson, J., Privalova, E. M., Ninkina, N. N., & Davies, A. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09335.1998 · Cited by 169
Dynamic Observation of Dopamine Autoreceptor Effects in Rat Striatal Slices
Kennedy, R. T., Jones, S. R., & Wightman, R. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09391.x · Cited by 166
Tong, G., Malenka, R. C., & Nicoll, R. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80141-5 · Cited by 147
Jensen, P. H., Højrup, P., Hager, H., Nielsen, M. S., JACOBSEN, L., Olesen, O. F., Gliemann, J., & Jakes, R. (1997) · Biochemical Journal · doi:10.1042/bj3230539 · Cited by 143
Gomis, A., Burrone, J., & Lagnado, L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06309.1999 · Cited by 125
Role of Phospholipase D Activation in Nervous System Physiology and Pathophysiology
Klein, J., Caspi, V. C., Liscovitch, M., & Löffelholz, K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041445.x · Cited by 108
Jensen, P. H., Sørensen, E. S., Petersen, T. E., Gliemann, J., & Rasmussen, L. K. (1995) · Biochemical Journal · doi:10.1042/bj3100091 · Cited by 97
Heterogeneity of evoked dopamine overflow wihin the striatal and striatoamygdaloid regions
Garris, P. A., Ciolkowski, E. L., & Wightman, R. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90606-8 · Cited by 75
Calcium regulation of neurotransmitter release: reliably unreliable?
Goda, Y., & Südhof, T. C. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80027-0 · Cited by 70
Paik, S. R., Lee, J., Kim, D.-H., Chang, C., & Kim, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01537-8 · Cited by 69
Phospholipid signalling: Rho is only ARF the story
Frohman, M. A., & Morris, A. J. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00634-6 · Cited by 64
Research works printed but not linked: 1
- Starke, 1989, Modulation of presynaptic release by presynaptic autoreceptors, J. Neurochem., 2, 449
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Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737
Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563
Pathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024
Self-citation
Metadata
- Authors
- Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., & Rosenthal, A.
- Affiliations
- University of California, San Francisco (US)
- New York State Psychiatric Institute (US)
- Universitat de València (ES)
- Genentech (US)
- Stanford Medicine (US)
- Corresponding author
- Rosenthal, Arnon
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 25
- Issue
- 1
- Pages
- 239-252
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2171281715
- Cited by
- 1,722
- References
- 51
- Citations by year
- 2026: 39 · 2025: 41 · 2024: 53 · 2023: 50 · 2022: 67 · 2021: 61 · 2020: 65 · 2019: 68 · 2018: 61 · 2017: 70 · 2016: 61 · 2015: 75 · 2014: 82 · 2013: 71 · 2012: 77
- FWCI
- 39.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alpha-synuclein, Parkinson's disease, nigrostriatal dopamine system, dopamine release, presynaptic modulation, paired-pulse facilitation, calcium-dependent release, striatal dopamine, dopamine reuptake, dopamine signaling
- MeSH terms
- Amphetamine, Animals, Calcium, Corpus Striatum, Dopamine, Female, Hippocampus, Locomotion, Male, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Substantia Nigra, Dopamine Agents, Gene Expression, Autoreceptors, Presynaptic Terminals, Long-Term Potentiation, Mice, Knockout, Glutamic Acid, rab3A GTP-Binding Protein, Mice, Synucleins, alpha-Synuclein, Calbindins, S100 Calcium Binding Protein G
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