Cited by 425Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

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Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming

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Betz, Andrea, Thakur, Pratima, Junge, Harald J., Ashery, Uri, Rhee, Jeong-Seop, Scheuss, Volker, Rosenmund, Christian, Rettig, Jens, Brose, Nils·2001·Neuron

DOI 10.1016/s0896-6273(01)00272-0

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Abstract

Synaptic neurotransmitter release is restricted to active zones, where the processes of synaptic vesicle tethering, priming to fusion competence, and Ca2+-triggered fusion are taking place in a highly coordinated manner. We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally. Disruption of this interaction causes a loss of fusion-competent synaptic vesicles, creating a phenocopy of Munc13-1-deficient neurons. RIM1 binding and vesicle priming are mediated by two distinct structural modules of Munc13-1. The Munc13-1/RIM1 interaction may create a functional link between synaptic vesicle tethering and priming, or it may regulate the priming reaction itself, thereby determining the number of fusion-competent vesicles.

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Authors: Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., & Brose, N.
Affiliations: Max Planck Institute of Experimental Medicine (DE)
Max Planck Institute for Biophysical Chemistry (DE)
Corresponding author: Brose, Nils
ORCID: Junge, Harald J.
Ashery, Uri
Scheuss, Volker
Rosenmund, Christian
Rettig, Jens
Brose, Nils
Venue: Neuron
Publisher: Elsevier BV
Published: 2001-04
Volume: 30
Issue: 1
Pages: 183-196
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)00272-0
OpenAlex: W1994381304
Cited by: 425
References: 36
Citations by year: 2026: 7 · 2025: 12 · 2024: 7 · 2023: 17 · 2022: 23 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 25 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 14 · 2012: 15
FWCI: 8.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4490 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
GRO (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: Munc13-1, RIM1, synaptic vesicle priming, active zone, synaptic vesicle tethering, synaptic vesicle fusion, neurotransmitter release, protein-protein interaction
MeSH terms: Animals, Binding Sites, Cells, Cultured, DNA-Binding Proteins, Fungal Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Synaptic Transmission, Neurons, Synaptic Vesicles, Zinc Fingers, Sequence Homology, Amino Acid, Alternative Splicing, Protein Structure, Tertiary, Presynaptic Terminals, Neurotransmitter Agents, Protein Isoforms, Two-Hybrid System Techniques, rab3A GTP-Binding Protein

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Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming

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