The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index; 29 of the 54 sources its claims cite were checked for support.
Cognitive reserve in ageing and Alzheimer's disease
Open accessAbstract
The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure activities in later life, can increase this reserve. For example, the risk of developing Alzheimer's disease is reduced in individuals with higher educational or occupational attainment. Reserve can conveniently be divided into two types: brain reserve, which refers to differences in the brain structure that may increase tolerance to pathology, and cognitive reserve, which refers to differences between individuals in how tasks are performed that might enable some people to be more resilient to brain changes than others. Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review argues that cognitive reserve explains why people differ in how much Alzheimer’s disease pathology or age-related brain change they can tolerate while still functioning. It synthesizes epidemiologic, neuroimaging, postmortem, and intervention evidence, and concludes that reserve is modifiable but that causal interventions remain unproven.
Key findings
- Reserve is split into brain reserve, a more passive quantitative tolerance tied to brain size or neurons/synapses, and cognitive reserve, an active functional process in which pre-existing or compensatory networks help cope with damage.
- Epidemiologic studies cited found that fewer than 8 years of education carried 2.2 times higher dementia risk, low occupational attainment carried 2.25 times higher risk, and greater leisure activity was linked to 38% lower risk; a review of 22 cohort studies estimated higher reserve reduced dementia risk by 46%.
- After Alzheimer’s disease becomes clinically apparent, higher reserve is associated with faster decline: memory scores fell about one point yearly on average, with an additional point yearly in those with higher education or occupation.
- Imaging and autopsy evidence indicated that at matched clinical severity, higher education was linked to greater parietotemporal blood-flow deficit and, in 130 elders, each additional year of education reduced the pathology–cognition association by 0.088 standard units; fMRI work distinguished neural reserve from neural compensation.
Methods
- Narrative review by the author, integrating his group’s and others’ epidemiologic cohort studies, functional and resting neuroimaging studies, postmortem analyses, and cognitive or exercise intervention trials.
- Cited samples include 593 non-demented adults aged 60 or older followed for 4 years, 130 elders who had cognitive evaluation before autopsy, and a preliminary 90-person older-adult Space Fortress training study.
- Main analysis is conceptual synthesis rather than a new primary study or formal meta-analysis; it draws on a cited systematic review of 22 cohort studies for one pooled estimate.
Limitations
- Stated: epidemiologic evidence is correlational and cannot establish causation; controlled intervention studies are needed, and no study to date has shown changes in the key endpoints of slowed cognitive decline or reduced Alzheimer’s disease risk.
- Stated: clinical use of biomarkers and imaging for reserve is premature because prognostic implications are not fully established, and cognitive training evidence is mixed.
- Evident from the text: this is a narrative review without formal risk-of-bias assessment, many findings come from the author’s own research program, and the interaction between brain reserve and cognitive reserve remains unresolved.
Model-written summary. Check it against the paper before relying on it.
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Claims the paper makes
39 Own interpretation · 14 No full text of the sources · 12 No basis given · 10 Supported · 10 Own result · 8 Partly supported · 5 Supported so far · 3 Not checked yet · 2 Couldn’t confirm · 1 Sources not found · accuracy not yet measured
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“This idea is supported by a set of studies that suggest that prevalence or incidence of dementia is lower in individuals with larger brains13, 14.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [13] Katzman, 1988, Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques, Ann Neurol source
- Supportedcites [14] Schofield, 1997, An association between head circumference and Alzheimer's disease in a population-based study of aging, Neurology source
The Discussion (p. 5) reports that smaller head circumference was associated with higher prevalence of Alzheimer’s disease. The paper uses head circumference as an index of premorbid brain size (p. 1), so its finding supports the citing sentence’s hedged association. This study measured prevalence of Alzheimer’s disease, not incidence of dementia generally. (LLM, conf=0.88)
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Second, compared to individuals with lower CR, those with higher CR performed better even when they use the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [42] Steffener, 2011, Supporting performance in the face of age-related neural changes: testing mechanistic roles of cognitive reserve, Brain Imaging Behav source
The Results (Model C) report that, in older adults, higher cognitive reserve reduced the negative effect of network 2 expression on task performance. The Discussion likewise says older adults with greater reserve maintained performance better as network 2 expression increased. (LLM, conf=0.88)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Those who engaged in more leisure activities had 38% less risk of developing dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Supportedcites [24] Scarmeas, 2001, Influence of leisure activity on the incidence of Alzheimer's disease, Neurology source
The Discussion explicitly states that subjects with high leisure activity had 38% less risk of developing dementia. The Results report a relative risk of 0.62 (95% CI 0.46–0.83), consistent with that figure. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The rate of decline is more rapid in individuals with high reserve than those with low reserve, even when accounting for a multitude of other factors that may contribute to disease course27, 28, 46.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Supportedcites [27] Stern, 1999, Rate of memory decline in AD is related to education and occupation: cognitive reserve?, Neurology sourceExperimental — accuracy not yet measured
The DOI was not indexed for paper-scoped Semantic Scholar search, so the cited paper’s full text could not be checked directly. A systematic review, “Education and Dementia in the Context of the Cognitive Reserve Hypothesis” (search score 0.789), explicitly attributes more rapid memory decline in Alzheimer’s patients with higher education and occupational attainment to Stern et al. (1999). This supports the central claim, though the retrieved passage does not verify which other factors the original analysis accounted for. (LLM, conf=0.81)
- Supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
No paper-scoped Semantic Scholar snippets were available for Scarmeas et al. (2006). However, “Higher education affects accelerated cortical thinning in Alzheimer's disease” explicitly cites Scarmeas et al. (2006) among studies finding more rapid cognitive decline after Alzheimer’s onset in patients with higher education (snippet score 0.534). This supports the claim through a secondary citation, although the available evidence does not independently verify which other factors Scarmeas et al. adjusted for. (LLM, conf=0.76)
- Supportedcites [46] Hall, 2007, Education delays accelerated decline on a memory test in persons who develop dementia, Neurology sourceExperimental — accuracy not yet measured
Hall’s (2007) title establishes the finding of delayed accelerated memory decline in people who develop dementia. A Semantic Scholar snippet from “Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly” describes the same pattern: education is associated with a delayed change point followed by faster decline (score 0.52). Hall’s full text was unavailable in the paper-scoped search, so the specific assertion about accounting for other factors could not be checked directly; the available evidence supports the core paraphrase, not every qualification. (LLM, conf=0.72)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In a young group of subjects we identified an activation network that was expressed during the stimulus presentation phase of both tasks and whose increase in expression with increasing load correlated with CR.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [43] Stern, 2008, A common neural network for cognitive reserve in verbal and object working memory in young but not old, Cereb Cortex source
The Discussion identifies a pattern in young subjects during stimulus presentation whose load-related activation had a similar relationship with cognitive reserve in both the letter and shape tasks. The Canonical Variates Analysis reports significant expression of that pattern in both tasks and relates its load-related expression to cognitive-reserve scores. (LLM, conf=0.91)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Similar analysis demonstrated a comparable protective effect of occupational attainment33 and leisure activities34.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [33] Stern, 1995, Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology, Neurology source
- Supportedcites [34] Scarmeas, 2003, Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis, Arch Neurol source
The cited paper’s Results report an inverse association between activity scores and cerebral blood flow after controlling for clinical severity, which the authors interpret as consistent with cognitive reserve. The Conclusions describe analogous findings for occupational attainment and note evidence linking leisure activities to reduced dementia risk. The citation supports the leisure-activities part of the sentence; occupational attainment has a separate citation. (LLM, conf=0.85)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“For example, at a given level of clinical severity, AD patients with higher education have a more severe pattern of AD-related changes on PET scan than those with lower education44, 45.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Not checked — no full text of the sourcecites [44] Garibotto, 2008, Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence, Neurology source
- Supportedcites [45] Kemppainen, 2008, Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease, Ann Neurol source
The Abstract reports that high- and low-educated patients with mild Alzheimer’s disease had the same degree of cognitive deterioration, while the high-educated group showed greater amyloid-tracer uptake and lower glucose metabolism on PET. The Discussion likewise describes more pronounced amyloid accumulation and neuronal dysfunction in the high-educated group. (LLM, conf=0.93)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“In AD patients matched for clinical severity, we found an inverse relationship between resting rCBF and years of education32.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Supportedcites [32] Stern, 1992, Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease, Ann Neurol source
The Procedures (p. 2) state that rCBF was measured under resting conditions. The Results (pp. 2–3) report greater parietotemporal flow reductions with more education in AD groups that did not differ on clinical measures; the relationship at the P3 detector remained significant after controlling for dementia severity. (LLM, conf=0.92)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The neural implementation of CR might take two forms: neural reserve and neural compensation16, 38.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
In “Neural Mechanisms Underlying CR,” Stern explicitly says that the neural implementation of cognitive reserve might take two forms: neural reserve and neural compensation. The “Brain Reserve and Cognitive Reserve” section also describes them as two proposed components. (LLM, conf=0.95)
- Supportedcites [38] Stern, 2005, Brain networks associated with cognitive reserve in healthy young and old adults, Cereb Cortex source
The Introduction (p. 1) explicitly proposes two complementary facets of the neural implementation of cognitive reserve: neural reserve and neural compensation. The paper then defines and contrasts them in the Introduction (pp. 1–2). (LLM, conf=0.95)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These observations using cerebral blood flow have been replicated by other groups as well35, 36.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [35] Alexander, 1997, Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis, Am J Psychiatry source
- Supportedcites [36] Perneczky, 2006, Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography, J Neurol Neurosurg Psychiatry source
The Results report an inverse association between schooling and glucose metabolism in patients with Alzheimer’s disease. The Discussion says these findings are supported by other groups’ cerebral-blood-flow studies, while noting that the results do not match exactly because of differences in samples and methods. This paper used FDG-PET rather than measuring cerebral blood flow itself. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 15
- It may state two separate claims as one. 17
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“In contrast, the concept of CR suggests that the brain actively attempts to cope with brain damage by using pre-existing cognitive processing approaches or by enlisting compensatory approaches15, 16.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [15] Stern, 2002, What is cognitive reserve? Theory and research application of the reserve concept, J Int Neuropsychol Soc source
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
The “Brain Reserve and Cognitive Reserve” section states that active models such as CR propose that the brain copes with damage using pre-existing cognitive processes or enlisting compensatory processes. This directly supports the paraphrase; no page number is provided in our copy. (LLM, conf=0.95)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“We replicated this observation in patients with incident AD28 and also found more rapid decline in cognitive function in AD patients who engaged in more leisure activities prior to dementia onset29.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Partly supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
- Supportedcites [29] Helzner, 2007, Leisure activity and cognitive decline in incident Alzheimer disease, Arch Neurol source
Split into 2 atoms — 2 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Using a covariance method to analyze the imaging data, we identified a spatial pattern of fMRI activation that was expressed by both groups and whose expression increased as the task became more difficult.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [39] Stern, 2012, Task difficulty modulates young-old differences in network expression, Brain Res source
The Functional imaging section identifies a spatial pattern common to young and old participants. The Discussion states that its expression increased logarithmically with task difficulty. Page numbers are not provided in our copy. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In a follow-up analysis41, we found that atrophy in a key area within the first network (i.e. the one that was used by both young and old) was associated with decreased efficiency in that network and increased utilization of the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Partly supportedcites [41] Steffener, 2009, The impact of age-related changes on working memory functional activity, Brain Imaging Behav sourceExperimental — accuracy not yet measured
The Abstract and Conclusion report that lower grey-matter volume in a region of the primary network was associated with greater secondary-network recruitment. The Discussion interprets this as compensation for an affected primary network, but the Results report no significant association between regional grey-matter volume and primary-network expression; decreased efficiency of that network was not demonstrated. (LLM, conf=0.86)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For example, Basak et al.50 had elders play a complex role-playing game,”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Partly supportedcites [50] Basak, 2008, Can training in a real-time strategy video game attenuate cognitive decline in older adults?, Psychol Aging sourceExperimental — accuracy not yet measured
The Method > Participants section says older adults were assigned to play Rise of Nations, and the General Discussion reports transfer benefits after 23.5 hours of training. The paper identifies Rise of Nations as a complex real-time strategy game, not a role-playing game. Its Abstract reports improvement on a subset of cognitive tasks, rather than across the entire battery (page numbers unavailable in our copy). (LLM, conf=0.90)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In research with young adults, one particular training approach produced excellent improvement in gameplay, but, more importantly, also showed transfer of training to other tasks.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [55] Gopher, 1994, Transfer of skill from a computer game trainer to flight, Hum Factors source
- Not checked — no full text of the sourcecites [56] Gopher, 1989, Practice under changing priorities: an approach to the training of complex skills, Acta Psychol source
- Partly supportedcites [57] Blumen, 2010, Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability, Front Aging Neurosci sourceExperimental — accuracy not yet measured
The Introduction (‘The space fortress game and emphasis change instructions’; page unavailable) reports that emphasis-change instructions improved Space Fortress performance in younger adults compared with standard instructions. It says those instructions *may* be important for transfer, but does not report that this approach demonstrated transfer to other tasks. The General Discussion (page unavailable) says future studies will determine whether such transfer occurs. (LLM, conf=0.86)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Those who rely more on this alternate network can still perform the task, but do so more poorly.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“On the average scores on a memory test decline by about one point yearly, but in those with higher educational or occupational attainment scores decline by an additional point each year.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The first network was used by both young and old subjects, and consisted of areas often associated with working memory.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the second network was primarily characterized by activation in parahippocampal areas and was used consistently only by the older subjects.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Each of these networks is a group of brain areas that seem to work together as the task is harder.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given these assumptions, individuals with higher CR will begin their cognitive decline when pathology is more advanced and thus have less time until they reach the point where pathology overwhelms function.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- The authors state this as an assumption: There is a common point in all people where pathology is so severe that function cannot be maintained.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Still, while in some ways interdependent, brain reserve and CR make independent in addition to synergistic contributions to understanding individual differences in clinical resilience to brain pathology.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, the cognitive or neural mechanism that underlies this reserve is unknown.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, clinicians must be aware that in the presence of pathology there should still be a period of time during which even the most sensitive measures would fail to detect cognitive change.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Individuals with high reserve, by definition, will not demonstrate disease-related clinical symptoms as early as individuals with low levels of reserve.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Since people with greater reserve should be able to tolerate more AD pathology, the onset of clinical dementia should be delayed.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirectn = 593- Asserted: passes — The authors put it forward as true.
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In the paper
“It is possible that individuals with more efficient or higher capacity networks could have more resilience in the face of age- or disease-related changes.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
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In the paper
“Only controlled studies can truly establish that some set of interventions or experiences are beneficial.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“In schizophrenia, small effects of cognitive remediation were noted, particularly in stable patients and when combined with adjunctive rehabilitation52.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not matchedcites [52]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Not matched
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In the paper
“While the original observations concern easily measurable variables like education or occupational attainment, more recent studies have delved more deeply into lifestyle factors, cognitively stimulating behaviors, personality factors and the like.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
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In the paper
“However, the exact”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“These findings support the possibility that it may be possible to intervene even later in life in order to impart reserve, slow age-related cognitive decline, and prolonged healthy aging.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“This is a hopeful idea, since it suggests that changes in lifestyle even later in life might impart reserve against age-related cognitive decline or dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Similarly, focused training has improved working memory capacity and shown transfer of training to nontrained working memory tasks51.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [51] Klingberg, 2010, Training and plasticity of working memory, Trends Cogn Sci source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
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In the paper
“Studies using these endpoints will be very expensive because they will require a large number of participants and will have to be conducted over several years.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While epidemiologic studies can only describe correlations and do not directly test causation, they are useful for deriving hypotheses and exploring ideas.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“By shifting emphasis from game to game, participants cannot fall into a fixed strategy. They must develop the ability to deal with the entire task as a whole – skills that might be termed attentional allocation or executive control.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
The authors state this as an assumption.
Disease pathology slowly develops over time independently of cognitive reserve, and pathology begins many years before the onset of clinically diagnosed Alzheimer's disease.
“The assumption is that disease pathology slowly develops over time independently of CR, and that the pathology begins many years before the onset of clinically diagnosed AD.”
The authors state this as an assumption.
There is a common point in all people where pathology is so severe that function cannot be maintained.
“However, we reasoned that there is common point in all people where the pathology is so severe that function cannot be maintained.”
The paper relies on this without support.
No study to date has shown change in slowed rate of cognitive decline in aging or reduced risk of developing Alzheimer's disease.
“No study to date has shown change in either of these endpoints.”
The paper relies on this without support.
The brain both passively and actively attempts to cope with brain changes or pathology.
“Since the brain both passively and actively attempts to cope with brain changes or pathology, it is important to understand the factors that contribute to this resilience.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Researchers have long reported that people with more years of formal education are at lower risk for Alzheimer's and other dementias than those with fewer years of formal education.80,[144][145][146][147][148][149]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [146]
The cited source says what the claim attributes to it.
In the citing paper
“This concept was theoretically framed by Park and Bischof (2013) as “scaffolding,” similar to the closely related cognitive reserve theory proposed by Stern (2012).”
In the citing paper
“supporting the theory that a greater cognitive reserve could help protect against development of LOAD117.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [117]
In the citing paper
“The level of education, a surrogate marker of cognitive reserves (Stern, 2012), is an important determinant of the expression of VCI, such that for a given level of neuropathology higher education is associated with less cognitive deficits (Zieren et al., 2013).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Stern, 2012
In the citing paper
“These findings lead to the suggestion that higher social engagement and support experienced both before and during lockdown due to the COVID-19 pandemic might have had a protective/mitigating role by contributing to cognitive (51) and affective reserve (52).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [51]
In the citing paper
“Cognitive reserve theory suggests that individuals differ in their level of resilience against brain pathology and hence may exhibit differences in cognitive function despite equivalent levels of pathology (Stern, 2002(Stern, , 2012)).”
From Living alone and cognitive function in later life (2019) · cites this paper as Stern, 2012
In the citing paper
“The theory suggests that individuals differ in their degree of resilience against age-related brain pathology and hence may show differences in cognitive function in relation to an equivalent level of pathology [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Cognitive reserve is a theoretical concept that may account for the role of social isolation and its association with cognitive outcomes in later life.”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Such individuals are likely to receive less cognitive stimulation through social contact, resulting in lower cognitive reserve and hence poorer cognitive function [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
Citations
Cites
What is cognitive reserve? Theory and research application of the reserve concept
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Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Stern, Y. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.03.004 · Cited by 2,943
Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
A Meta-Analysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes
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Training and plasticity of working memory
Klingberg, T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.002 · Cited by 1,585
Influence of education and occupation on the incidence of Alzheimer's disease
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Self-citationAgeing, fitness and neurocognitive function
Kramer, A. F., Hahn, S., Cohen, N. J., Banich, M. T., McAuley, E., Harrison, C. R., Chason, J., Vakil, E., Bardell, L., Boileau, R. A., et al. (1999) · Nature · doi:10.1038/22682 · Cited by 1,394
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Cited by
Sorted by citations
Items 2,001–2,100 of 3,537
Advances in Alzheimer’s disease: mechanistic insights and therapeutic targets
Jia, Y.-J., Ge, Y., Li, B., Yang, Y., Chen, H., Liu, J., Guo, J., Yu, J., Ye, K., Wang, J., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-2991-7 · Cited by 6
“Individual differences in susceptibility to age-related brain changes and AD pathology are closely interconnected (Stern, 2012; Wilson Iii et al., 2023).”
Reppermund, S. (2021) · International Psychogeriatrics · doi:10.1017/s1041610221000508 · Cited by 5
“Thus, rather than being a fixed entity, the contributors to cognitive reserve can change across the lifespan (Stern, 2012).”
BackgroundLi, L., Ni, L., Wang, X., & Sheng, C. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.09.017 · Cited by 5
Bousiges, O., Cretin, B., Muller, C., Botzung, A., Sanna, L., Anthony, P., Philippi, N., Demuynck, C., & Blanc, F. (2023) · GeroScience · doi:10.1007/s11357-023-00883-6 · Cited by 7
“There is indeed an effect of cognitive reserve that allows the age at AD onset to be delayed [43, 44].”
Manrique-Gutiérrez, G., Rodríguez-Cayetano, Q., Samudio-Cruz, M. A., & Carrillo-Mora, P. U. (2024) · Brain Injury · doi:10.1080/02699052.2024.2304876 · Cited by 5
Sun, Y., Han, X., Li, Z., Qiu, Y., Hu, Y., Zhang, Y., Dai, Y., Wei, H., Xu, Q., & Zhou, Y. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1361436 · Cited by 5
“Cognitive reserve refers to individual differences in how tasks are performed that may allow some people to be more resilient than others (Stern, 2012).”
BackgroundChen, R., Byrd, D. R., Whitfield, K. E., & Williams, D. R. (2024) · Ethnicity & Disease · doi:10.18865/ethndis-2023-42 · Cited by 5
Large Language Models as a Tool for Cognitive Stimulation: Chatbot Book Clubs for Seniors
Zhou, H., Chen, E., Wen, S., Wang, Y., & Norel, R. (2024) · IEEE International Conference on Digital Health (ICDH) · doi:10.1109/icdh62654.2024.00029 · Cited by 6
Han, H. J., Ko, M. J., Park, A., Cheun, J., Nam, Y.-J., & Kim, T. H. (2024) · Digital Health · doi:10.1177/20552076241284810 · Cited by 7
“13 It has been introduced to explain the variance among individuals in their resilience to brain aging and pathological alterations, including those seen in Alzheimer ’ s disease.”
BackgroundWang, H., Lu, J., Wang, Y., & Li, L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.060 · Cited by 6
Factors Associated With Post-Stroke Cognitive Impairment: A Narrative Review
Shin, S., Yeo, S. M., Lee, B. C., & Chang, W. H. (2024) · Brain & Neurorehabilitation · doi:10.12786/bn.2024.17.e20 · Cited by 6
Beveridge, J., Sheth, P., Thakkar, S., Silverglate, B., & Grossberg, G. T. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2445015 · Cited by 6
“In some cases, higher IQ has been associated with slower cognitive decline, indicating that premorbid intelligence plays a role in cognitive resilience [3,30].”
InfluentialHensen, T., Ahmad, S., Kastenmüller, G., Kraaij, R., Ghanbari, M., Ikram, M. A., Kaddurah‐Daouk, R., & Thiele, I. (2024) · Gut Microbes Reports · doi:10.1080/29933935.2024.2443171 · Cited by 5
A cross-sectional network analysis of successful aging in a resilience-based framework
Brinkhof, L. P., Ridderinkhof, K. R., de Wit, S., Krugers, H. J., & Murre, J. M. J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315445 · Cited by 8
Triolo, F., Grande, G., Ekström, I., Laukka, E. J., Fors, S., Marseglia, A., & Dekhtyar, S. (2025) · Cortex · doi:10.1016/j.cortex.2025.02.001 · Cited by 5
Li, Y., & Heng-guo, S. (2025) · SSM - Population Health · doi:10.1016/j.ssmph.2025.101778 · Cited by 8
“Moreover, the predictive importance of education level validates its contribution to cognitive reserve, showing that individuals with higher educational attainment tend to maintain better cognitive levels during periods of decline (Stern, 2012).”
Optimized prediction of cognition based on brain morphometry across the adult life span
Tsapanou, A., Stern, Y., & Habeck, C. G. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.015 · Cited by 5
“More detailed information about the 2 studies can be found in previous publications (Habeck et al., 2016, 2017; Razlighi et al., 2017; Stern, 2009, 2012; Stern et al., 2014).”
BackgroundMethodSelf-citationAn, J., Sun, W., Zhang, W., Yu, Z., Gao, K., Zhao, J., Sun, S., An, J., & Ji, A. (2020) · Applied Neuropsychology Adult · doi:10.1080/23279095.2020.1778477 · Cited by 5
“Educational attainment can increase cognitive reserve (Stern, 2012).”
Kang, D. W., Wang, S., Na, H.-R., Kim, N.-Y., Lim, H. K., & Lee, C. U. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.644148 · Cited by 5
“Inclusion criteria were as follows: (1) Participants with or without subjective memory complaints, beyond what would be expected for age, (2) Normal memory function, quantified by scoring above age, sex, and education adjusted cutoffs on the WLM, WLR, and WLRc domain, (3) MMSE-K score between 24 and 30, (4) Clinical D…”
BackgroundLiu, X., Zeng, Q., Luo, X., Li, K., Hong, H., Wang, S., Guan, X., Wu, J., Zhang, R., Zhang, T., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.591347 · Cited by 5
Art Attendance and Change in Cognitive Function Among U.S. Community-Dwelling Chinese Older Adults
Petrovsky, D., Wu, B., Hodgson, N. A., & Dong, X. (2021) · Journal of Applied Gerontology · doi:10.1177/07334648211017339 · Cited by 5
“…factors— such as higher levels of education, occupational complexity, and engagement in physical, cognitive, and social activities— that may increase cognitive reserve, making older adults less susceptible to the underlying Alzheimer’s disease (AD) pathology (Stern, 2002, 2012; Stern et al., 1999).”
BackgroundWorkplace stress and cognitive functions (a population based study of adults aged 25—44 years)
Гафаров, В. В., Суханов, А. В., Громова, Е. А., Panov, D., Вахтанговна, Д. Д., Gagulin, I. V., & Гафарова, А. В. (2021) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2021-4-30-36 · Cited by 5
“From the biological point of view, it can be assumed that stimulation of cognitive activity increases the plasticity of neural circuits, allowing the brain to delay agerelated decline in cognitive functions and pathological changes [20, 21].”
BackgroundFunctional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults
Kraft, J. N., Albizu, A., O’Shea, A. M., Hausman, H. K., Evangelista, N. D., Boutzoukas, E. M., Hardcastle, C., Etten, E. J. V., Bharadwaj, P. K., Song, H., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab332 · Cited by 5
Revisiting the effect of retirement on Cognition: Heterogeneity and endowment
Jung, D., Lee, J., & Meijer, E. (2021) · The Journal of the Economics of Ageing · doi:10.1016/j.jeoa.2021.100361 · Cited by 5
Harrington, K., Craven, M. P., Wilson, M. L., & Landowska, A. (2022) · JMIR Serious Games · doi:10.2196/32489 · Cited by 5
“Lifestyle factors such as occupation, leisure activities, and educational attainment may help to build cognitive reserve, which could help to mitigate or modify the clinical expression of dementia despite underlying neuropathology [9].”
BackgroundLinassi, F., Laurenzis, A. D., Maran, E., Gadaldi, A., Spanò, L., Gerosa, G., Pittarello, D. G., Zanatta, P., & Carron, M. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.810046 · Cited by 5
“Schooling years, in fact, alter the “cognitive reserve,” an innovative concept that explains why some people can tolerate more age- and comorbidity-related brain injury changes than others to maintain better cognitive function (Stern, 2012).”
BackgroundAblinger, I., Dressel, K., Rott, T., Lauer, A. A., Tiemann, M., Batista, J. P., Taddey, T., Grimm, H. S., & Grimm, M. O. W. (2022) · Biomedicines · doi:10.3390/biomedicines10112922 · Cited by 5
Association of prediabetes with reduced brain volume in a general elderly Japanese population
Tatsuo, S., Watanabe, K., Ide, S., Tsushima, F., Tatsuo, S., Matsuzaka, M., Murakami, H., Ishida, M., Iwane, T., Daimon, M., et al. (2023) · European Radiology · doi:10.1007/s00330-023-09509-z · Cited by 5
“Brain reserve is a “passive” cognitive capacity that is thought to depend on individual brain structure and circuit complexity [27], and patients with less brain reserve capacity are thought to have a lower threshold for functional impairment, following the onset of brain pathology.”
BackgroundGroechel, R. C., Tripodis, Y., Alosco, M. L., Mez, J., Qiu, W. Q., Mercier, G., Goldstein, L. E., Budson, A. E., Kowall, N. W., & Killiany, R. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.03.005 · Cited by 5
“Similarly, we observed other profiles that indicate non-AD related pathologic changes as o u r P r - p o o cognitive reserve and how older adults are able to maintain cognitive abilities despite pathological diseases burden (Stern, 2012).”
The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women
Schuurmans, I. K., Hoepel, S. J. W., Cecil, C. A. M., Hillegers, M. H. J., Ikram, M. A., & Luik, A. I. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220923 · Cited by 6
Rocha, N. P., Carreira, E. X., Prado, A. C. D. A., et al. (2023) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0042-1759761 · Cited by 5
“…previous studies that demonstrated the protective effects of education and cognitive reserve on cognitive aging and reduced risk of dementia, 11,36 including reports involving patients with PD. 37,38 The mean score obtained in the MMSE was considerably higher than the cutoff score…”
InfluentialJeong, S. H., Cha, J., Jung, J. H., Yun, M., Sohn, Y. H., Chung, S. J., & Lee, P. H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230187 · Cited by 5
Barriers to brain health behaviours: results from the Five Lives Brain Health Ireland Survey
Dukelow, T., Vassilev, P., Lawrence, E. G., Jacobson, L., Koychev, I. G., Muhammed, K., & Kennelly, S. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1101514 · Cited by 5
“In the context of dementia, education has long been thought to impact cognitive reserve, reducing susceptibility to age-related changes and Alzheimer’s Disease (AD) pathology (Stern, 2012).”
BackgroundSimon, S. S., Varangis, E. M. L., Lee, S., Gu, Y., Gazes, Y., Razlighi, Q. R., Habeck, C. G., & Stern, Y. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.10.001 · Cited by 5
Self-citationGutiérrez, M. A., Wahrendorf, M., Milani, S. A., Mejía-Arango, S., Wong, R., & Downer, B. G. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad155 · Cited by 6
Kim, J., Kim, S., Um, Y. H., Wang, S., Kim, R. E. Y., Choe, Y. S., Lee, J., Kim, D., Lim, H. K., Lee, C. U., et al. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.23.1113 · Cited by 6
“The concept of cognitive reserve suggests that the brain compensates for the pathology by adapting and reorganizing its neural networks [4]; individuals with greater cognitive reserve tolerate more AD pathology, and the onset of cognitive symptoms of dementia is often delayed [3].”
BackgroundYAŞLI BİREYLERİN DEPRESYON DÜZEYİNE ETKİ EDEN FAKTÖRLERİN İNCELENMESİ
Türk, A., & Işık, A. (2023) · Nevşehir Hacı Bektaş Veli Üniversitesi SBE Dergisi · doi:10.30783/nevsosbilen.1307489 · Cited by 5
Anbar, R., Jones, S. H., Chaturvedi, N., Sudre, C. H., Richards, M., Sultan, S. R., & Hughes, A. D. (2024) · Atherosclerosis Plus · doi:10.1016/j.athplu.2024.01.002 · Cited by 5
“Another potential source of inter-study difference is the extent of cognitive reserve [42].”
BackgroundRao, S., Cai, Y., Zhong, Z., Gou, T., Wang, Y., Liao, S., Qiu, P., & Kuang, W. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1336385 · Cited by 5
“To highlight this point, research has shown that having a higher cognitive reserve, which refers to the brain’s ability to make flexible and efficient use of cognitive networks (networks of neuron-to-neuron connections), helps a person’s ability to cope and compensate for brain damage (48, 53).”
BackgroundBrain reserve affects the expression of cognitive reserve networks
Coors, A., Lee, S., Gazes, Y., et al. (2024) · Human Brain Mapping · doi:10.1002/hbm.26658 · Cited by 5
“However, individuals with high CR have also been shown to have a more rapid cognitive decline and a shorter morbidity period once they become demented (Stern, 2012).”
BackgroundSelf-citationIncident Dementia After Spontaneous Intracerebral Hemorrhage
Zhang, Z.-T., & Lim, M. J. R. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-240111 · Cited by 3
“Demographicriskfactorsforpost-ICHdementia includeolderageatindexICH[4–6]andloweredu-cationallevel[4],whicharereflectiveofreduced cognitivereserve[73](Fig.1).”
Cardiovascular risk factors among older persons with cognitive frailty in middle income country
Ibrahim, A., Singh, D. K. A., Ludin, A. F. M., Sakian, N. I. M., Rivan, N. F. M., & Shahar, S. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i17.3076 · Cited by 4
Li, Y., Liu, Q., Si, H., Zhou, W., Yu, J., Bian, Y., & Wang, C. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105533 · Cited by 5
Pérez, V., Hidalgo, V., & Salvador, A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115140 · Cited by 5
“In this regard, the analysis of resting state EEG rhythms (rsEEG) is a non-invasive technique used to investigate the electrophysiological parameters of the brain activity.”
MethodCox, A., & Fernandes, M. A. (2024) · Brain Injury · doi:10.1080/02699052.2024.2376769 · Cited by 5
“Divided attention paradigms are likely more sensitive to cognitive deficits experienced in those with mTBI, as they tax cognitive reserve (52), a construct also hypothesized to decrease with advancing age, particularly when there is a developing dementia (53).”
He, Y., Wang, Z., Zhao, Y., Han, X., Guo, K., Sun, N., & Liu, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1474504 · Cited by 5
“…with clinical populations, such as those with dementia and mild cognitive impairment, there is increasing evidence about its utility in preventing cognitive decline (Butler et al., 2018; Gates et al., 2019), with the possible mechanism built on the premise of cognitive reserve (Stern, 2012).”
BackgroundCognitive reserve in individuals with frontotemporal dementia: a systematic review
Grebe, L. A., Vonk, J. M. J., Galletta, E. E., & Goral, M. (2024) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2024.2410207 · Cited by 9
“Therefore, more cognitive deficits are evident in the later stages of disease (Stern, 2012; Zahodne et al., 2019).”
Marital status, brain health, and cognitive reserve among diverse older adults
Lee, J. H., Scambray, K. A., Morris, E. P., Sol, K., Palms, J. D., Zaheed, A. B., Martinez, M. N., Schupf, N., Manly, J. J., Brickman, A. M., et al. (2024) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617724000638 · Cited by 5
Liu, G., Bao, T., Gao, C., Hong, C., Guan, B., Huang, Y., Zheng, X., & Luo, Y. (2024) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-024-02800-4 · Cited by 8
“Late-life stage enhancing factor was measured by physical activity on a weekly basis according to some previous studies, in which physical activity was regarded as a cog - nitive reserve-enhancing factor [ 40, 42].”
InfluentialKendrick, K. M., & Yao, D. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16121439 · Cited by 5
Detection of neurodevelopmental diversity in memory clinics—Validation of a self-report measure
Seifan, A., Shih, C., Hackett, K., et al. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2018.03.009 · Cited by 5
Suh, J., Park, Y. H., Kim, H., Jang, J., Kang, M. J., Yang, J., Baek, M. J., & Kim, S. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5072 · Cited by 5
“Cognitive reserve is the capacity of the brain to cope with cerebral damage and minimize clinical manifestations.(30) According to the concept of cognitive reserve, individuals with higher cognitive reserve have more advanced neuropathology in the brain at the same degree of cognitive impairment and a more rapid rate…”
BackgroundWolf, L. K., & Gunderman, R. B. (2019) · American Journal of Roentgenology · doi:10.2214/ajr.19.21506 · Cited by 5
Yang, H., Gu, S., Wu, Y., Jiang, Y., Zhao, J., & Cheng, Z. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01659-9 · Cited by 5
“The CR theory suggests that, under the same degree of pathological alteration, people with more years of education aremore likely to be clinically healthy or have a less clinically severe condition (Stern 2012).”
BackgroundCasamitjana, A., Petrone, P., Molinuevo, J. L., Gispert, J. D., & Vilaplana, V. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00648 · Cited by 5
“Age and sex are used as the main confounders for non-AD effects while we acknowledge that many other factors (e.g., environmental, genetic) might be added to the model (36).”
BackgroundThe Impact of Age, Gender, and Marital Status on Age-Associated Cognitive Decline
MacKinnon-Lee, K.-A., & Bahr, M. (2020) · Psychology · doi:10.4236/psych.2020.118082 · Cited by 5
“Individuals who have higher levels of cognitive reserve, which refers to the brain’s ability to actively cope and function after cognitive deterioration, are more likely to maintain higher levels of cognitive performance (Satz, 1993; Stern, 2009).”
BackgroundInfluentialFerré, P., Jarret, J., Brambati, S., Bellec, P., & Joanette, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.535770 · Cited by 6
“These activities are also associated with a lower risk of developing mild cognitive impairment (MCI) or dementia (Scarmeas et al., 2003; Valenzuela and Sachdev, 2006; Stern, 2012; Franzmeier et al., 2016).”
BackgroundInfluentialCan reading increase cognitive reserve?
Chan, C. K. L. (2021) · International Psychogeriatrics · doi:10.1017/s1041610220001246 · Cited by 2
“While epidemiological studies have demonstrated that aspects of life experience can build cognitive reserve against age- or disease-related dementia pathology, the precise components needed to improve cognitive reserve remain unclear (Stern, 2012).”
BackgroundDai, J. M., Nishi, A., Tran, N., Yamamoto, Y., Dewey, G., Ugai, T., & Ogino, S. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1952073 · Cited by 6
Smailović, U., Kåreholt, I., Koenig, T. W., Ashton, N. J., Winblad, B. G., Höglund, K., Nilsson, P., Zetterberg, H., Blennow, K., & Jelić, V. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201234 · Cited by 6
“Moreover, markers of synaptic degeneration may serve as molecular substrates of cognitive reserve, which may account for different likelihoods of disease progression rates among individuals with similar levels of AD-related neuropathology [11].”
BackgroundAssociations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
Yoon, H., Kim, S.-G., Kim, S. H., Woo, J. I., Seo, E. H., & Initiative, A. D. N. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182212159 · Cited by 5
Social Inference from Middle to Older Adulthood
Martin, A. K., Ceslis, A., & Robinson, G. A. (2022) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acac027 · Cited by 5
Wiśniowska, J., Łojek, E., Chabuda, A., Kruszyński, M., Kupryjaniuk, A., Kulesza, M., Olejnik, A., Orzechowska, P., & Wolak, H. (2022) · Applied Neuropsychology Adult · doi:10.1080/23279095.2022.2106864 · Cited by 5
“According to the cognitive resource theory, it is especially important to support the cognitive functions and build the cognitive reserve during the whole life, in order to prevent the development or rapid progression of dementia (Stern, 2012).”
Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington’s disease
Papoutsi, M., Flower, M. D., Moss, D. J. H., Holmans, P., Estevez‐Fraga, C., Johnson, E. B., Scahill, R. I., Rees, G. E., Langbehn, D. R., Tabrizi, S. J., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac279 · Cited by 6
“Education alone is a well-known predictor of cognitive function.(47) We next wanted to understand whether the effect captured by intellectual enrichment on cognitive function is primarily due to the contribution of education or is incremental to the effect of education.”
BackgroundRietman, M. L., Onland‐Moret, N. C., Nooyens, A. C. J., Ibi, D., van Dijk, K. W., Samson, L. D., Pennings, J. L. A., Schipper, M., Wong, A., Spijkerman, A. M. W., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02258-5 · Cited by 5
“In addition, genetic markers can also help identify people who are at risk of (accelerated) cognitive decline and possibly postpone or reduce cognitive decline, for example by increasing the cognitive reserves [13].”
BackgroundStudying additive effects of combining rTMS with cognitive control training: a pilot investigation
Dalhuisen, I., Schutte, C., Bramson, B., Roelofs, K., van Eijndhoven, P., & Tendolkar, I. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1201344 · Cited by 4
“As cognitive control declines with age, it may have been at too high a level in our young sample for the manipulation to have an effect (Stern, 2012; Lövdén et al., 2020).”
BackgroundCappa, S. F., & Canevelli, M. (2021) · Sustainable development goals series · doi:10.1007/978-3-030-81058-0_23 · Cited by 5
Pacifico, D., Sabatini, S., Fiordelli, M., Annoni, A. M., Frei, A. L., Puhan, M. A., Graf, G., & Albanese, E. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04311-4 · Cited by 5
“The more advanced stages of cognitive impairment in LCTs residents were likely related to a greater extent of structural and functional brain damage, which may hamper and compromise the buffering effect of cognitive reserve on cognitive impairment [7, 45].”
BackgroundResultIbrahim, A., Singh, D. K. A., Ludin, A., Subramaniam, P., Ai-Vyrn, C., Ibrahim, N., Haron, H., Safien, A. M., Khalid, N. M., Ponvel, P., et al. (2024) · The journal of prevention of Alzheimer's disease · doi:10.14283/jpad.2024.111 · Cited by 8
“Although age-related changes are inevitable, it is possible to modify pathological changes through interventions as a dementia risk reduction initiative (3, 4).”
Emotionserkennung, Theory of Mind und Empathie bei Multipler Sklerose
Ayache, S. S., Chalah, M. A., Kümpfel, T., Padberg, F., Lefaucheur, J., & Palm, U. (2017) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0043-118846 · Cited by 5
The Nun Study and Alzheimer’s disease: Quality of vocation as a potential protective factor?
Keohane, K., & Balfe, M. (2017) · Dementia · doi:10.1177/1471301217725186 · Cited by 5
Piccirilli, M., D’Alessandro, P., Germani, A., et al. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.05.035 · Cited by 5
Ihle, A., Gouveia, É. R., de Gouveia, B. R. F. O., & Kliegel, M. (2020) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000508363 · Cited by 5
Aging with Intellectual Disability: Dementia and Cognitive Decline
Sheerin, F. K., McCallion, P., McGlinchey, E., O’Dwyer, M., Reilly, E., & McCarron, M. (2020) · Autism and child psychopathology series · doi:10.1007/978-3-030-46835-4_19 · Cited by 5
Kilecioğlu, E., Raman, I., & Raman, E. (2020) · Applied Neuropsychology Adult · doi:10.1080/23279095.2020.1796668 · Cited by 5
“two groups reported here is cognitive reserve (Stern, 2012).”
BackgroundA Novel Computational Proxy for Characterizing Cognitive Reserve in Alzheimer’s Disease
Zhang, Y., Initiative, A. D. N., Hao, Y., Li, L., Xia, K., & Guorong Wu, A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201011 · Cited by 6
Kadlec, H., Dujela, C., Beattie, B., & Chappell, N. (2018) · Aging & Mental Health · doi:10.1080/13607863.2016.1226766 · Cited by 4
“, 2009; Sachdev & Valenzuela, 2009; Stern, 2012), and a number of neural mechanisms for cognitive reserve based on neuroimaging studies have been proposed (Stern, 2012) and brain areas related to these mechanisms are being identified (Collangeli et al.”
BackgroundInfluentialThe Montreal Cognitive Assessment (MoCA) and Brain Structure
Sammer, G., & Lenz, E. (2020) · GeroPsych · doi:10.1024/1662-9647/a000226 · Cited by 5
Experiences are encoded by brainwide reprogramming of synaptome architecturePreprint
Woods, H., Günar, Ü., Gillard, S. C., Notman, B., Yuan, K., Dominic, D., Robson, E., Varga, G., Komiyama, N. H., Qiu, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.12.693919 · Cited by 5
Ownby, R. L., & Caballero, J. (2025) · Aging and Health Research · doi:10.1016/j.ahr.2025.100258 · Cited by 4
Borelli, W. V., Ferreira, P. C. L., Brum, W. S., Ferrari‐Souza, J. P., Carello‐Collar, G., Holz, M. R., Souza, V. T., Strelow, M. Z., Formoso, C., Chaves, M. L. F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03192-w · Cited by 12
Street dancing enhances cognitive reserve in young females: an fNIRS study
Wang, Y., Zheng, Q., Han, Y., Fan, Y., Liu, H., & Wang, H. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1640555 · Cited by 4
“Among these strategies, enhancing cognitive reserve is considered an essential means to delay cognitive decline (Stern, 2012; Livingston et al., 2020).”
Song, Y.-Z., Li, Y., Dong, Q., Zhang, Y. L., Wang, J., Han, X., Mao, M., Dong, Y., Tang, S. H., Hou, T., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251385261 · Cited by 4
“10 This implies that older adults with higher CR could with-stand greater pathological changes in the brain and preserve cognitive function.”
Clinical specificities and outcome of LGI1-antibody encephalitis according to age, sex and HLA
Campetella, L., Villagrán‐García, M., Farina, A., et al. (2025) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2025-335960 · Cited by 4
Velloso, V., Herrera, V., Bomilcar, I., de Almeida, J. S., & Mograbi, D. C. (2025) · Scientific Reports · doi:10.1038/s41598-025-19583-6 · Cited by 4
“…or training, as recommended by WHO’s guidelines for reducing risk of cognitive decline and dementia, can help maintain brain health and prevent cognitive decline by improving cognitive reserve 10 which refers to the brain’s ability to adapt or compensate for neuropathology or damage 11 .”
Gao, T., Li, Y., Niu, L., Wang, Z., Li, S., Niu, Y., Li, Y., Meng, Y., Gao, X., & Xu, X. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.09.020 · Cited by 6
Jain, S., & Vohora, D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1676926 · Cited by 4
“Furthermore, reducing the burden of cellular senescence has been shown to improve cognitive aging and dementia related to Alzheimer’s disease (Chen et al., 2023; Liu et al., 2024; Stern, 2012).”
Chauca, J. M. N., Sánchez, M., Quintana, N. G., Márquez, K. L. M. D. C., Juarez, B. A. C., Mendoza, N. R., & Díaz, M. A. A. (2026) · Neurology International · doi:10.3390/neurolint18010010 · Cited by 4
“Beyond molecular mediators, functional and structural imaging, electrophysiological techniques, and emerging biochemical markers provide complementary evidence of how the aging brain reorganizes itself to preserve cognition [17–19 ,47,”
InfluentialMorita, A., & Fujiwara, T. (2021) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14238 · Cited by 4
Challenging Assumptions Around Dementia
Ashworth, R., Fyvel, S., Hill, A., Maddocks, C., Qureshi, M., Ross, D., Hay, S., Robertson, M., Gilder, W., Henry, W., et al. (2023) · Springer eBooks · doi:10.1007/978-3-031-27223-3 · Cited by 4
Human restricted CHRFAM7A gene increases brain efficiency
Jakimovski, D., Dorn, R. P., Regno, M. D., Bartnik, A., Bergsland, N., Ramanathan, M. K., Dwyer, M. G., Benedict, R. H. B., Zivadinov, R., & Szigeti, K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1359028 · Cited by 4
“The reserve was originally introduced in the field of Alzheimer’s Disease (AD) where patients with greater pre-morbid brain volume and higher educational attainment tent to withstand greater amount of pathology and ultimately have better long-term outcomes (Stern, 2012).”
BackgroundKelberman, M. A., Winther, K. E., Medvedeva, Y. M., & Donaldson, Z. R. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105647 · Cited by 4
Impact of white matter hyperintensity volume on cognition among US Mexican American adults
Graves, L. V., Diaz, M. M., Dayan, E., & For the Health and Aging Brain Study: Health Disparities (HABS-HD) Team (2024) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617724000316 · Cited by 4
“It is well-documented that education plays an integral role in facilitating cognitive reserve and that higher educational attainment in turn reduces dementia risk (Livingston et al., 2020; Stern, 2012; Stern et al., 2020).”
Roberts, S. M., Bruce, R. M., Hope, T. M. H., Geva, S., Anderson, S., Woodgate, H., Ledingham, K., Gajardo‐Vidal, A., Lorca‐Puls, D. L., Crinion, J., et al. (2024) · Aphasiology · doi:10.1080/02687038.2024.2434864 · Cited by 6
“In the dementia literature, it has been argued that greater cognitive reserve may delay the onset of cognitive decline (Meng et al., 2012; Stern, 2009, 2012; Stern et al., 2020) or the detection of cognitive decline when premorbid abilities were very high.”
James, S., Sudre, C. H., Barnes, J., Cash, D. M., Chiou, Y., Coath, W., Keshavan, A., Lu, K., Malone, I. B., Murray‐Smith, H., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae431 · Cited by 5
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“35 Even a few years of formal education can contribute to cognitive reserve.”
Semyanov, A. V., & Verkhratsky, A. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00002-4 · Cited by 5
Pelegrini, L. N. D. C., Manzine, P. R., Popolin, C. P., et al. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.04.003 · Cited by 4
Flórez‐García, V., Torres-Saballeth, J., Molina, R. T., Acosta-Reyes, J. L., Guevara-Romero, E., Nohora, N., Santacruz‐Salas, E., & Acosta, T. (2025) · BMC Public Health · doi:10.1186/s12889-025-22577-8 · Cited by 4
“Higher levels of education contribute to the development of cognitive reserve [13], which enhances the brain’s resilience against age-related neuropathology and neurodegenerative diseases [14].”
Yang, Z. X., Sheng, J., Zhang, Q., Zhao, X., Song, Y., Dong, G., Zhang, R., Zhao, H., Wang, J., Pan, R., et al. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin26584 · Cited by 7
“Nevertheless, there are some contradictory features present; individuals exhibiting cognitive resilience demonstrate a slower progression of cognitive impairment, yet once neurodegenerative symptoms manifest, they may experience a more rapid decline in cognitive abilities [ 145].”
Metadata
- Authors
- Stern, Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Stern, Yaakov
- ORCID
- Stern, Yaakov
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 11
- Issue
- 11
- Pages
- 1006-1012
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3507991
- OpenAlex
- W2144907160
- Cited by
- 3,557
- References
- 59
- Citations by year
- 2026: 412 · 2025: 352 · 2024: 311 · 2023: 343 · 2022: 281 · 2021: 303 · 2020: 350 · 2019: 292 · 2018: 244 · 2017: 213 · 2016: 176 · 2015: 125 · 2014: 93 · 2013: 58 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (R01AG026158, R01AG014671)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cognitive reserve, brain reserve, Alzheimer's disease, cognitive aging, dementia risk, educational attainment, occupational attainment, leisure
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Cognitive Reserve
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