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Chronotherapeutics (light and wake therapy) in affective disorders
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The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic subtype, respond with marked improvement within hours. Treatment can be a single or repeated sleep deprivation, total (all night) or partial (second half of the night). Relapse can be prevented by daily light therapy, concomitant administration of SSRIs, lithium (for bipolar patients), or a short phase advance of sleep over 3 days following a single night of wake therapy. Combinations of these interventions show great promise. (2) Light therapy is effective for major depression--not only for the seasonal subtype. As an adjuvant to conventional antidepressants in unipolar patients, or lithium in bipolar patients, morning light hastens and potentiates the antidepressant response. Light therapy shows benefit even for patients with chronic depression of 2 years or more, outperforming their weak response to drugs. This method provides a viable alternative for patients who refuse, resist or cannot tolerate medication, or for whom drugs may be contraindicated, as in antepartum depression. (3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority.
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“Furthermore, follow up treatment with daily light therapy or a short phase advance in the sleep/wake cycle can also prevent relapse (Berger et al., 1997; Riemann et al., 1999; Wirz-Justice et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Wirz-Justice et al., 2005
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“Building on the example of the American Psychiatric Association ( Golden et al. in press ), national psychiatric associations should exert clinical leadership and develop standards of practice for chronotherapeutics.”
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Self-citationStem Cell Factor (SCF) is a putative biomarker of antidepressant response
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Metadata
- Authors
- WIRZ-JUSTICE, A., BENEDETTI, F., BERGER, M., LAM, R. W., MARTINY, K., TERMAN, M., & WU, J. C.
- Affiliations
- International Society for Infectious Diseases (US)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-03-10
- Volume
- 35
- Issue
- 7
- Pages
- 939-944
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2111639473
- Cited by
- 291
- References
- 58
- Citations by year
- 2026: 15 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 13 · 2019: 6 · 2018: 13 · 2017: 15 · 2016: 18 · 2015: 18 · 2014: 15 · 2013: 19 · 2012: 21
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- chronotherapy, wake therapy, phototherapy, sleep deprivation, major depressive disorder, bipolar disorder, antidepressant response, relapse prevention, seasonal affective disorder, chronic depression, antenatal depression, selective serotonin reuptake inhibitors, lithium, sleep phase advance, treatment-resistant depression
- MeSH terms
- Clinical Trials as Topic, Humans, Phototherapy, Prognosis, Treatment Outcome, Mood Disorders
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