Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder
Open accessAbstract
Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants.
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Immediate and marked response of ADHD symptoms to stimulant medications suggests main underlying pathophysiological process may involve deficits or imbalances in catecholaminergic, dopaminergic, and nicotinergic functioning.
“The immediate and marked response of ADHD symptoms to stimulant medications such as amphetamines and methylphenidate, which increase levels of synaptic dopamine, suggests that the main underlying pathophysiological process may involve deficits or imbalances in catecholaminergic, dopaminergic, and nicotinergic functioning [109-111].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [110]
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“This hypothesis is supported by studies showing differences in dopamine transporter (DAT) density in relevant striatal areas in ADHD patients compared to controls (Cheon et al. 2003; Dougherty et al. 1999; Dresel et al. 2000; Krause et al. 2000, 2002, 2003; Larisch et al. 2006; Spencer et al. 2005; Volkow et al. 2007).”
- Authors
- Krause, K.-H., Dresel, S. H., Krause, J., Kung, H. F., Tatsch, K., & Ackenheil, M.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Medprevent Ottobrunn (DE)
- University of Pennsylvania (US)
- Corresponding author
- Krause, Klaus-Henning
- ORCID
- Kung, Hank F.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06
- Volume
- 5
- Issue
- 02
- Pages
- 111-3
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2100715167
- Cited by
- 88
- References
- 14
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- attention deficit hyperactivity disorder, nicotine, striatal dopamine transporter, smoking, dopamine transporter density, adult ADHD
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Female, Ganglionic Stimulants, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Nicotine, Psychiatric Status Rating Scales, Smoking, Stimulation, Chemical, Tomography, Emission-Computed, Single-Photon, Neostriatum, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
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