Cited by 361Tryptophan and brain disordersTreatment of Major DepressionNeuroinflammation and Neurodegeneration Mechanisms

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A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

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Khairova, Rushaniya A., Machado-Vieira, Rodrigo, Du, Jing, Manji, Husseini K.·2009·The International Journal of Neuropsychopharmacology

DOI 10.1017/s1461145709009924PMC PMC2771334

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Abstract

A growing body of data suggests that hyperactivation of the immune system has been implicated in the pathophysiology of major depressive disorder (MDD). Several pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) have been found to be significantly increased in patients with MDD. This review focuses on these two cytokines based on multiple lines of evidence from genetic, animal behaviour, and clinical studies showing that altered levels of serum TNF-alpha and IL-1 are associated with increased risk of depression, cognitive impairments, and reduced responsiveness to treatment. In addition, recent findings have shown that centrally expressed TNF-alpha and IL-1 play a dual role in the regulation of synaptic plasticity. In this paper, we review and critically appraise the mechanisms by which cytokines regulate synaptic and neural plasticity, and their implications for the pathophysiology and treatment of MDD. Finally, we discuss the therapeutic potential of anti-inflammatory-based approaches for treating patients with severe mood disorders. This is a promising field for increasing our understanding of the mechanistic interaction between the immune system, synaptic plasticity, and antidepressants, and for the ultimate development of novel and improved therapeutics for severe mood disorders.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
American Journal of Pathology
(2015) · American Journal Of Pathology · doi:10.2353/ajpath · Cited by 4,961
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
The medial temporal lobe
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial
Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069 · cited 2×
“…Johnson, USA) has been found to attenuate the depressive symptoms that Downloaded from https://academic.oup.com/ijnp/article-abstract/12/4/561/657745 by guest on 29 July 2018 accompany immune system activation in psoriasis (Dantzer, 1999; Krishnan et al. 2007; Tyring et al. 2006; Yirmiya, 2000).”
Background
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
Stellwagen, D., Beattie, E. C., Seo, J. Y., & Malenka, R. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-04.2005 · Cited by 985
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Tkachev, D., Mimmack, M., Ryan, M. M., Wayland, M., Freeman, T., Jones, P., Starkey, M., Webster, M., Yolken, R., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 940
Sickness behavior as a new target for drug development
Kent, S., Bluthé, R.-M., Kelley, K. W., & Dantzer, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90012-u · Cited by 867
Journal of Affective Disorders
Flint, A. J., & Rifat, S. L. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(96)00074-2 · Cited by 864
Cytokine‐Induced Sickness Behavior: Mechanisms and Implications
Dantzer, R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05827.x · Cited by 825
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 785
Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.
Lieberman, A. P., Pitha, P. M., Shin, H. S., & Shin, M. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6348 · Cited by 783
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Acute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735
Stressful Life Events and Previous Episodes in the Etiology of Major Depression in Women: An Evaluation of the “Kindling” Hypothesis
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1243 · Cited by 721
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653
Depression: a case of neuronal life and death?
Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 630
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 625
Increased Plasma Concentrations of Interleukin-6, Soluble Interleukin-6, Soluble Interleukin-2 and Transferrin Receptor in Major Depression
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 622
Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta.
Chung, I. Y., & Benveniste, E. N. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.8.2999 · Cited by 609
Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
Boka, G., Anglade, P., Wallach, D., Javoy-Agid, F., Agid, Y., & Hirsch, É. C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90684-x · Cited by 600
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572
Decreased memory performance in healthy humans induced by stress-level cortisol treatment
Newcomer, J. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.527 · Cited by 546
A dual role for interleukin-1 in hippocampal-dependent memory processes
Goshen, I., Kreisel, T., Ounallah-Saad, H., Renbaum, P., Zalzstein, Y., Ben‐Hur, T., Levy‐Lahad, E., & Yirmiya, R. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.004 · Cited by 535
Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity
Albensi, B. C., & Mattson, M. P. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2 · Cited by 527
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression
Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K. D., Gray, N. A., Zarate, C. A., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00117-3 · Cited by 507
Self-citation
“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
Vitkovic, L., Bockaert, J., & Jacque, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740457.x · Cited by 506
Stress and Plasticity in the Limbic System
Sapolsky, R. M. (2003) · Neurochemical Research · doi:10.1023/a:1026021307833 · Cited by 503
A neuromodulatory role of interleukin-1β in the hippocampus
Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498
3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 496
Depression, stress and immunological activation: The role of cytokines in depressive disorders
Connor, T. J., & Leonard, B. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)00990-9 · Cited by 480
Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment
Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434
Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433
p53: 25 years after its discovery
Hofseth, L. J., Hussain, S. P., & Harris, C. C. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.009 · Cited by 428
Clinical depression and inflammatory risk markers for coronary heart disease
Miller, G. E., Stetler, C. A., Carney, R. M., Freedland, K. E., & Banks, W. A. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02863-1 · Cited by 424
Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system
Pickering, M., Cumiskey, D., & O'Connor, J. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030734 · Cited by 421
Neuropsychiatric Symptoms Associated With Hepatitis C and Interferon Alpha: A Review
Dieperink, E. W., Willenbring, M., & Ho, S. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.867 · Cited by 417
On the nature and pattern of neurocognitive function in major depressive disorder.
Zakzanis, K. K., Leach, L., & Kaplan, E. (1998) · PubMed · Cited by 406
Impaired interleukin‐1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
Avital, A., Goshen, I., Kamsler, A., Segal, M., Iverfeldt, K., Richter‐Levin, G., & Yirmiya, R. (2003) · Hippocampus · doi:10.1002/hipo.10135 · Cited by 396
Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus
Bellinger, F. P., Madamba, S. G., & Siggins, G. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90959-q · Cited by 393
Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder
Tuglu, C., Kara, S. H., Caliyurt, O., Vardar, E., & Abay, E. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1566-z · Cited by 391
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
Heyser, C. J., Masliah, E., Samimi, A., Campbell, I. L., & Gold, L. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1500 · Cited by 386
Cytokine Actions in the Central Nervous System
Benveniste, E. N. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00015-x · Cited by 383
Effects of antidepressants on the production of cytokines
Kenis, G., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003164 · Cited by 370
Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation
Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359
Journal of Neural Transmission
(2013) · Journal of Neural Transmission · doi:10.1007/702.1435-1463 · Cited by 354
Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
Zarate, C. A., Payne, J. L., Singh, J. B., Quiroz, J. A., Luckenbaugh, D. A., Denicoff, K. D., Charney, D. S., & Manji, H. K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.013 · Cited by 343
Self-citation
Yeast and apoptosis
Jin, C., & Reed, J. C. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm832 · Cited by 340
A Discriminating Messenger RNA Signature for Bipolar Disorder Formed by an Aberrant Expression of Inflammatory Genes in Monocytes
Padmos, R. C., Hillegers, M. H. J., Knijff, E. M., Vonk, R., Bouvy, A., Staal, F. J. T., de Ridder, D., Kupka, R. W., Nolen, W. A., & Drexhage, H. A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.395 · Cited by 336
In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse
Cunningham, E. T., Wada, E., Carter, D., Tracey, D. E., Battey, J., & Souza, E. B. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01101.1992 · Cited by 331
Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K., & Kato, T. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001437 · Cited by 331
Impairments of Neuroplasticity and Cellular Resilience in Severe Mood Disorders: Implications for the Development of Novel Therapeutics
Manji, H. K., Duman, R. S., Duman, F. A. R. S., & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4260 · Cited by 330
Self-citation
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
Wichers, M., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003103 · Cited by 329
An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression
Zarate, C. A., Payne, J. L., Quiroz, J. A., Sporn, J., Denicoff, K. K., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.171 · Cited by 327
Self-citation
Tumor necrosis factor alters synaptic transmission in rat hippocampal slices.
Tancredi, V., D'Arcangelo, G., Grassi, F., Tarroni, P., Palmieri, G., Santoni, A., & Eusebi, F. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90071-e · Cited by 326
Cytokine imbalance in the pathophysiology of major depressive disorder
Kim, Y., Na, K.-S., Shin, K.-H., Jung, H., Choi, S., & Kim, J.-B. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.004 · Cited by 319
Interleukin‐6: a cytokine to forget
Balschun, D., Wetzel, W., del Rey, A., Pitossi, F. J., Schneider, H., Zuschratter, W., & Besedovsky, H. O. (2004) · The FASEB Journal · doi:10.1096/fj.04-1625fje · Cited by 317
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315
Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants
Rocher, C. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg122 · Cited by 307
Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders
Müller, N., & Ackenheil, M. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00179-6 · Cited by 305
Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons
Sun, X., Zhao, Y., & Wolf, M. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4603-04.2005 · Cited by 299
The monocyte-T-lymphocyte hypothesis of major depression
Maes, M., Smith, R., & Simon, S. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00066-j · Cited by 299
Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double‐blind, randomized, placebo‐controlled study
Nery, F. G., Monkul, E. S., Hatch, J. P., Fonseca, M., Zunta‐Soares, G. B., Frey, B. N., Bowden, C. L., & Soares, J. C. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.912 · Cited by 298
Behavioral Effects of Cytokines
Larson, S. J., & Dunn, A. J. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0643 · Cited by 295
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290
Inflammation, Glutamate, and Glia in Depression:A Literature Review
McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289
Psychomotor stimulants and neuronal plasticity
Wolf, M. E., Sun, X., Mangiavacchi, S., & Chao, S. Z. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.006 · Cited by 288
Cytokine profiles in bipolar affective disorder: focus on acutely ill patients.
O'Brien, S. M., Scully, P., Scott, L. V., & Dinan, T. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.11.015 · Cited by 285
Illness, Cytokines, and Depression
YIRMIYA, R., POLLAK, Y., MORAG, M., REICHENBERG, A., BARAK, O., AVITSUR, R., SHAVIT, Y., OVADIA, H., WEIDENFELD, J., MORAG, A., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05412.x · Cited by 284
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?
Carlezon, W. A., & Nestler, E. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02289-0 · Cited by 281
Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain.
Lacroix, S., & Rivest, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020452.x · Cited by 280
Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus
Bonaccorso, S., Marino, V., Biondi, M., Grimaldi, F., Ippoliti, F., & Maes, M. H. J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00264-1 · Cited by 280
Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?
Fontana, A., Weber, E., & Dayer, J. M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1696 · Cited by 277
How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli
Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., & Laflamme, N. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22304.x · Cited by 277
Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder
Zarate, C. A., Singh, J. B., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.021 · Cited by 275
Self-citation
Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
Eastwood, S. L., & Harrison, P. J. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00530-5 · Cited by 265
Case–control study of neurocognitive function in euthymic patients with bipolar disorder: An association with mania
Cavanagh, J., Beck, M. V., Muir, W. J., & Blackwood, D. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.4.320 · Cited by 264
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus
Barrientos, R. M., Higgins, E. A., Sprunger, D. B., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00043-8 · Cited by 263
Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder
Schloesser, R. J., Huang, J. Y., Klein, P. S., & Manji, H. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301575 · Cited by 262
Self-citation
TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen, B. B., Duman, C. H., Simen, A. A., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.013 · Cited by 255
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253
Pathways linking depression, adiposity, and inflammatory markers in healthy young adults
Miller, G. E., Freedland, K. E., Carney, R. M., Stetler, C., & Banks, W. A. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00057-6 · Cited by 252
Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
Pugh, C. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00098-4 · Cited by 251
Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor
Wagoner, N. J. V., Oh, J., Repovic, P., & Benveniste, E. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05236.1999 · Cited by 250
The Inhibitory Effects of Interleukin‐6 on Synaptic Plasticity in the Rat Hippocampus Are Associated with an Inhibition of Mitogen‐Activated Protein Kinase ERK
Tancredi, V., D’Antuono, M., Café, C., Giovedı̀, S., Buè, M. C., D’Arcangelo, G., Onofri, F., & Benfenati, F. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750634.x · Cited by 249
Peripheral and central proinflammatory cytokine response to a severe acute stressor
O'Connor, K. A., Johnson, J. D., Hansen, M. K., Wieseler Frank, J. L., Maksimova, E., Watkins, L. R., & Maier, S. F. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.006 · Cited by 247
Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms
Bonaccorso, S., Puzella, A., Marino, V., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Levrero, M., Egyed, B., Bosmans, E., et al. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00315-8 · Cited by 235
Raised Plasma Levels of Tumor Necrosis Factor α in Patients With Depression: Normalization During Electroconvulsive Therapy
Hestad, K. A., Tønseth, S., Støen, C. D., Ueland, T., & Aukrust, P. (2003) · The Journal of ECT · doi:10.1097/00124509-200312000-00002 · Cited by 235
Anti-inflammatory properties of desipramine and fluoxetine
Roumestan, C., Michel, A., Bichon, F., Portet, K., Detoc, M., Henriquet, C., Jaffuel, D., & Mathieu, M. N. (2007) · Respiratory Research · doi:10.1186/1465-9921-8-35 · Cited by 234
Interleukin-1β, but not interleukin-6, impairs spatial navigation learning
Oitzl, M. S., van Oers, H. J. J., Schöbitz, B., & de Kloet, E. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90468-3 · Cited by 234
Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress
Xu, L., Hölscher, C., Anwyl, R., & Rowan, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3204 · Cited by 234
The Increase in TNF-α Levels Is Implicated in NF-κB Activation and Inducible Nitric Oxide Synthase Expression in Brain Cortex after Immobilization Stress
Madrigal, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00292-5 · Cited by 232 · cited 2×
“…pre-clinical and clinical evidence indicate that acute and chronic stress elevates levels of proinflammatory cytokines, such as IL-1 and TNF-a and activates their signalling pathways in the periphery and CNS (Deinzer et al. 2004; Goebel et al. 2000; Madrigal et al. 2002; O’Connor et al. 2003).”
Background
The long-term potential of LTP
Malenka, R. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1258 · Cited by 229
Brain Interleukin-1 Is Involved in Spatial Memory and Passive Avoidance Conditioning
Yirmiya, R. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4072 · Cited by 228
Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system
Breder, C. D., Tsujimoto, M., Terano, Y., Scott, D. W., & Saper, C. B. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903370403 · Cited by 226
Cytokines, Stress, and Depression
Dantzer, R., Wollman, E. E., Vitković, L., & Yirmiya, R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_17 · Cited by 220
Spatial Learning Impairment in Mice Infected with Legionella pneumophila or Administered Exogenous Interleukin-1-β
Gibertini, M., Newton, C. A., Friedman, H., & Klein, T. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1012 · Cited by 219
Dissection of tumor-necrosis factor-α inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early—but not late—phase LTP
Butler, M. P., O'Connor, J. J., & Moynagh, P. N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.040 · Cited by 218
A Prospective Study of Neuropsychiatric Symptoms Associated With Interferon-α-2b and Ribavirin Therapy for Patients With Chronic Hepatitis C
Dieperink, E. W., Ho, S. B., THURAS, P. D., & Willenbring, M. L. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.2.104 · Cited by 217
Cytokines and serotonin transporter in patients with major depression
Tsao, C.-W., Lin, Y.-S., Chen, C.-C., Bai, C., & Wu, S.-R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.01.029 · Cited by 215
The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Membrane Localization: Relationship to Clinical Effects in Mood Disorders
Du, J., Suzuki, K., Wei, Y., Wang, Y., Blumenthal, R., Chen, Z., Falke, C., Zarate, C. A., & Manji, H. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301178 · Cited by 213
Self-citation
Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
Müller, N., & Schwarz, M. (2006) · Neurotoxicity Research · doi:10.1007/bf03033242 · Cited by 212
A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia
GOFF, D. C., Leahy, L., Berman, I., Posever, T. A., Herz, L. R., Leon, A. C., Johnson, S. A., & LYNCH, G. S. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200110000-00005 · Cited by 209
Involvement of Tumor Necrosis Factor Alpha in Hippocampal Development and Function
Golan, H. M. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg108 · Cited by 204
Low levels of circulating inflammatory cytokines—Do they affect human brain functions?
Pollmächer, T., Haack, M., Schuld, A., Reichenberg, A., & Yirmiya, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00004-1 · Cited by 202
Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00030-0 · Cited by 201
Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P. L., & Kanba, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.022 · Cited by 198
Anterograde Amnesia and Temporally Graded Retrograde Amnesia for a Nonspatial Memory Task after Lesions of Hippocampus and Subiculum
Clark, R. E., Broadbent, N., Zola, S. M., & Squire, L. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04663.2002 · Cited by 196
Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development
Gadient, R. A., & Otten, U. (1994) · Brain Research · doi:10.1016/0006-8993(94)91211-4 · Cited by 195
Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways.
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00019 · Cited by 189
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia
Vawter, M. P., Thatcher, L. N., Usen, N., Hyde, T. M., Kleinman, J. E., & Freed, W. J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001158 · Cited by 188
Delayed cytokine expression in rat brain following experimental contusion
Holmin, S., Schalling, M., Höjeberg, B., Nordqvist, A. S., Skeftruna, A.-K., & Mathiesen, T. I. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.86.3.0493 · Cited by 186
Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus
Tchélingérian, J., Quinonero, J., Booss, J., & Jacque, C. (1993) · Neuron · doi:10.1016/0896-6273(93)90312-f · Cited by 185
Enhanced Long-Term Synaptic Depression in an Animal Model of Depression
Holderbach, R., Clark, K., Moreau, J., Bischofberger, J., & Normann, C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.007 · Cited by 182
Nuclear factor-κB/Rel proteins
Grilli, M., & Memo, M. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00214-7 · Cited by 180
Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats
Bluthé, R.-M., Castanon, N., Pousset, F., Bristow, A., Ball, C., Lestage, J., Michaud, B., KELLEY, K. W., & Dantzer, R. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00077-8 · Cited by 179
Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock
Maier, S. F., & Watkins, L. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00930-o · Cited by 178
Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents
Shakesby, A. C., Anwyl, R., & Rowan, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03638.2002 · Cited by 173
Regulation of Neurogenesis and Gliogenesis by Stress and Antidepressant Treatment
Banasr, M., & Duman, R. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707783220929 · Cited by 169
Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity
Stewart, C. A., & Reid, I. (2000) · Psychopharmacology · doi:10.1007/s002130050045 · Cited by 157
Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression
Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157
Self-citation
GABA and glutamate systems as therapeutic targets in depression and mood disorders
Kendell, S. F., Krystal, J. H., & Sanacora, G. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.1.153 · Cited by 154
Immune system dysregulation in adolescent major depressive disorder
Gabbay, V., Klein, R. G., Alonso, C. M., Babb, J. S., Nishawala, M., De Jesus, G., Hirsch, G. S., Hottinger-Blanc, P. M. Z., & Gonzalez, C. J. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.07.022 · Cited by 153
Timing and Specificity of the Cognitive Changes Induced by Interleukin-2 and Interferon-α Treatments in Cancer Patients
Capuron, L., Ravaud, A., & Dantzer, R. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200105000-00007 · Cited by 148
Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes
Mizuta, I., Ohta, M., Ohta, K., Nishimura, M., Mizuta, E., & Kuno, S. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02098-5 · Cited by 145
Different immune patterns in melancholic and non-melancholic major depression
Rothermundt, M., Arolt, V., Fenker, J., Gutbrodt, H., Peters, M., & Kirchner, H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170058 · Cited by 143
The Effects of Psychological Stress on Leukocyte Subset Distribution in Humans: Evidence of Immune Activation
Maes, M. H. J., Bockstaele, D. R. V., Gastel, A. V., Song, C., Schotte, C., Neels, H. M., Meester, I. D., Scharpé, S., & Janca, A. (1999) · Neuropsychobiology · doi:10.1159/000026552 · Cited by 143
Expression of type I and type II interleukin-1 receptors in mouse brain
Parnet, P., Amindari, S., Wu, C., Brunke-Reese, D., Goujon, E., Weyhenmeyer, J. A., Dantzer, R., & Kelley, K. W. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90185-6 · Cited by 142
Cytokines Regulate Expression of the Type 1 Interleukin-1 Receptor in Rat Hippocampal Neurons and Glia
Friedman, W. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7595 · Cited by 140
The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
Curran, B. P., & O'Connor, J. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00405-5 · Cited by 138
Cell pathology in mood disorders
Rajkowska, G. (2002) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2002.35228 · Cited by 135 · cited 1×
“…abnormalities in hippocampal and frontal cortex areas in patients with MDD or BPD, especially those who have experienced multiple episodes (Bielau et al. 2005; MacQueen et al. 2003; Ongur et al. 1998; Rajkowska, 2000, 2002; Rajkowska et al. 2001; Rajkowska&Miguel-Hidalgo, 2007; Sheline, 2000).”
Background
Increased soluble interleukin‐2 receptor concentrations in suicide attempters
Nässberger, L., & Träskman‐Bendz, L. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03412.x · Cited by 135
Volume deficits of subcortical nuclei in mood disorders
Bielau, H., Trübner, K., Krell, D., Agelink, M. W., Bernstein, H., Stauch, R., Mawrin, C., Dános, P., Gerhard, L., Bogerts, B., et al. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0581-y · Cited by 133
Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus
Schaaf, M. J. M., Hoetelmans, R. W. M., de Kloet, E. R., & Vreugdenhil, E. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970515)48:4 · Cited by 131
The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation
Asefa, B., Klarmann, K. D., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Keller, J. R. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.10.002 · Cited by 131
The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro
Coogan, A. N., O'Neill, L. A. J., & O'Connor, J. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00100-1 · Cited by 129
Blood levels of cytokines in elderly patients with major depressive disorder
Brambilla, F., & Maggioni, M. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10005.x · Cited by 128
Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression
Taler, M., Gil‐Ad, I., Lomnitski, L., Korov, I., Baharav, E., Bar, M., Zolokov, A., & Weizman, A. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.010 · Cited by 121
Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks
Krishnan, R. R., Cella, D. F., Leonardi, C., Papp, K. A., Gottlieb, A. B., Dunn, M. E., Chiou, C. F., Patel, V. D., & Jahreis, A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08205.x · Cited by 121
Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.
Medana, I. M., Hunt, N. H., & Chaudhri, G. (1997) · Europe PMC (PubMed Central) · Cited by 120
Interleukin‐6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex
D’Arcangelo, G., Tancredi, V., Onofri, F., D’Antuono, M., Giovedı̀, S., & Benfenati, F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00011.x · Cited by 117
Possible association between ???G308A tumour necrosis factor-?? gene polymorphism and major depressive disorder in the Korean population
Jun, T., Pae, C., Hoon-Han, Chae, J., Bahk, W., Kim, K., & Serretti, A. (2003) · Psychiatric Genetics · doi:10.1097/00041444-200309000-00008 · Cited by 113
Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission.
Kubera, M., Kenis, G., Bosmans, E., Zieba, A., Dudek, D., Nowak, G., & Maes, M. H. J. (2000) · PubMed · Cited by 110
The Role of Hippocampal GluR1 and GluR2 Receptors in Manic-Like Behavior
Du, J., Creson, T. K., Wu, L., Ren, M., Gray, N. A., Falke, C., Wei, Y., Wang, Y., Blumenthal, R., Machado‐Vieira, R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3080-07.2008 · Cited by 106
Self-citation
Learning abilities, NGF and BDNF brain levels in two lines of TNF-α transgenic mice, one characterized by neurological disorders, the other phenotypically normal
Aloe, L., Properzi, G., Probert, L., Akassoglou, K., Kassiotis, G., Micera, A., & Fiore, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01748-5 · Cited by 102
Untitled work
Streit (2005) · doi:10.1179/016164105x49463 · Cited by 100
Differential effects of predator stress and the antidepressant tianeptine on physiological plasticity in the hippocampus and basolateral amygdala
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · cited 1×
“Recent studies also suggest that chronic administration of a selective serotonin reuptake inhibitor (SSRI) or an atypical antidepressant (tianeptine) increases LTP and blocks the stress-induced impairment of LTP and enhancement of LTD in the CA1 region (Holderbach et al. 2007; Vouimba et al. 2006).”
Background
Gene expression differences in bipolar disorder revealed by cDNA array analysis of post‐mortem frontal cortex
Bezchlibnyk, Y. B., Wang, J., McQueen, G. M., & Young, L. T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00628.x · Cited by 94
Tumor necrosis factor α: Activity dependent expression and promotion of cortical column sleep in rats
Churchill, L., Rector, D. M., Yasuda, K., Fix, C. F., Rojas, M. J., Yasuda, T., & Krueger, J. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.066 · Cited by 94
The interferon signaling network and transcription factor C/EBP-beta.
Li, H., Gade, P., Xiao, W., & Kalvakolanu, D. V. (2007) · PubMed · Cited by 93
Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices
Pizzi, M., Sarnico, I., Boroni, F., Benarese, M., Dréano, M., Garotta, G., Valerio, A., & Spano, P. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.022 · Cited by 92
Neuronal-associated tumor necrosis factor (TNFα): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration
Ignatowski, T. A., Noble, B. K., Wright, J. R., Gorfien, J. L., Heffner, R. R., & Spengler, R. N. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00107-0 · Cited by 90
Interleukin-1β production in dysthymia before and after pharmacotherapy
Anisman, H., Ravindran, A. V., Griffiths, J., & Merali, Z. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00211-5 · Cited by 85
Depression in medical illness: The role of the immune system
Yirmiya, R. (2000) · Western Journal of Medicine · doi:10.1136/ewjm.173.5.333 · Cited by 83
Tumor necrosis factor-α gene expression in the tissues of normal mice
Hunt, J. S., Chen, H.-L., Hu, X.-L., Chen, T.-Y., & Morrison, D. C. (1992) · Cytokine · doi:10.1016/1043-4666(92)90076-4 · Cited by 80
Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression
Carpenter, L. L., Heninger, G. R., Malison, R. T., Tyrka, A. R., & Price, L. H. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00460-3 · Cited by 79
Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments
Pugh, C., Johnson, J. D., Martin, D., Rudy, J. W., Maier, S. F., & Watkins, L. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02445-2 · Cited by 76
Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: characterization of brain cytokine and neuropeptide systems mRNAs
Gayle, D. A., Ilyin, S. E., Flynn, M. C., & Plata‐Saláman, C. R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00280-7 · Cited by 76
Interferon-γ-induced changes in synaptic activity and AMPA receptor clustering in hippocampal cultures
Vikman, K. S., Owe‐Larsson, B., Brask, J., Kristensson, K., & Hill, R. H. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03238-8 · Cited by 75
Interleukin‐1β (IL‐1β) gene and increased risk for the depressive symptom‐dimension in schizophrenia spectrum disorders
Rosa, A., Peralta, V., Papiol, S., Cuesta, M. J., Serrano, F., Martínez‐Larrea, A., & Fañanás, L. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20074 · Cited by 72
Interferon-α inhibits long-term potentiation and unmasks a long-term depression in the rat hippocampus
Mendoza-Fernández, V., Andrew, R. D., & Barajas‐López, C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02877-8 · Cited by 72
Regulation of interleukin 6 gene expression in rat
Schöbitz, B., van den Dobbelsteen, M. E. A., Holsboer, F., Sutanto, W., & de Kloet, E. R. (1993) · Endocrinology · doi:10.1210/endo.132.4.8462455 · Cited by 71
Tumor necrosis factor and interferon: cytokines in harmony
Bartee, E., Mohamed, M. R., & McFadden, G. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.05.015 · Cited by 69
Indicators of immune activation in depressed patients
Sluzewska, A. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_4 · Cited by 66
Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids
Song, C., Phillips, A. G., & Leonard, B. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02886.x · Cited by 66
Transcranial Magnetic Stimulation and Antidepressive Drugs Share Similar Cellular Effects in Rat Hippocampus
Levkovitz, Y. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00244-x · Cited by 64
Effects of Peripheral Administration of LPS on the Expression of Immunoreactive Interleukin‐1α, β, and Receptor Antagonist in Rat Brain
van Dam, A., Poole, S., Schultzberg, M., Zavala, F., & Tilders, F. J. H. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09557.x · Cited by 64
Cytokines in major depression
Maes, M. H. J. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90652-1 · Cited by 63
Brain-Derived Tumor Necrosis Factor-α and Its Involvement in Noradrenergic Neuron Functioning Involved in the Mechanism of Action of an Antidepressant
Reynolds, J. L., Ignatowski, T. A., Sud, R., & Spengler, R. N. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067835 · Cited by 61
An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-α production culminating in increases in noradrenergic neurotransmission
Reynolds, J. L., Ignatowski, T. A., Sud, R., & Spengler, R. N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.023 · Cited by 59
The Relationship of GAP‐43 to the Development and Plasticity of Synaptic Connectionsa
Benowitz, L. I., & Perrone‐Bizzozero, N. I. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb25914.x · Cited by 59
Acute stress effects on local Il-1β responses to pathogens in a human in vivo model
Deinzer, R., Granrath, N., Stuhl, H., Twork, L., Idel, H., Waschul, B., & Herforth, A. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.008 · Cited by 58
Targeting Neurotrophic/Growth Factor Expression and Signaling for Antidepressant Drug Development
Tanis, K. Q., Newton, S. S., & Duman, R. S. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363276 · Cited by 57
Angioedema: Clinical and Etiological Aspects
Kulthanan, K., Jiamton, S., Boochangkool, K., & Jongjarearnprasert, K. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/26438 · Cited by 55
Detection of cell-surface molecules, secreted products of single cells and cellular proliferation by enzyme immunoassay
Sedgwick, J. D., & Czerkinsky, C. C. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90075-5 · Cited by 54
Inhibition of Tumor Necrosis Factor-α Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats
Turnbull, A. V., Pitossi, F. J., Lebrun, J. J., Lee, S., Meltzer, J. C., Nance, D. M., del Rey, A., Besedovsky, H. O., & RIVIER, C. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03262.1997 · Cited by 52
Cytokines, Stress, and Depression
Dantzer, R., Yirmiya, R., & Wollman, E. E. (1999) · Advances in experimental medicine and biology · doi:10.1007/b102345 · Cited by 51
Low doses of interleukin-1β improve the leverpress avoidance performance of Sprague–Dawley rats
Brennan, F. X., Beck, K. D., & Servatius, R. J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00060-1 · Cited by 50
Blockade by lnterleukin-1-Alpha of Nitricoxidergic Control of Luteinizing Hormone-Releasing Hormone Release in vivo and in vitro
Rettori, V., Belova, N., Kamat, A., Lyson, K., Gimeno, M. A. F., & McCann, S. M. (2006) · NeuroImmunoModulation · doi:10.1159/000097095 · Cited by 46
Interleukin-1 receptors type I and type II in the mouse brain: kinetics of mRNA expressions after peripheral administration of bacterial lipopolysaccharide
Gabellec, M., Griffais, R., Fillion, G., & Haour, F. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00021-5 · Cited by 43
Caspase 1 deficiency reduces inflammation-induced brain transcription
Mastronardi, C. A., Whelan, F., Yildiz, O. A., Hannestad, J. O., Elashoff, D. A., McCann, S. M., Licinio, J., & Wong, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701366104 · Cited by 42
Questions raised by the cytokine hypothesis of depression
de Beaurepaire, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00005-3 · Cited by 39
Cytokines, p38 MAP kinase and the pathophysiology of depression
Miller, A. H., & Raison, C. L. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301032 · Cited by 39
Analysis of IL-1α, IL-1β, and IL-RA Polymorphisms in Dysthymia
Fertuzinhos, S., de Oliveira, J. R. M., Nishimura, A. L., Pontual, D., Carvalho, D. R., Sougey, É. B., Otto, P. A., & Zatz, M. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:22:3:251 · Cited by 39

Research works printed but not linked: 8

Manji, 2001, Psychopharmacology Bulletin, 35, 5
Zakzanis, 1998, Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 11, 111
Bielau, 2005, European Archives of Psychiatry and Neurological Sciences, 255, 401
10.1002/(sici)1098-2396(200002)35:23.0.co;2-p · DOI
10.1210/en.132.4.1569 · DOI
10.1002/(sici)1097-4547(19970515)48:43.0.co;2-7 · DOI
Li, 2007, Cellular & Molecular Immunology, 4, 407
Kubera, 2000, Polish Journal of Pharmacology, 52, 237

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See all 361

Authors: Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K.
Affiliations: National Institutes of Health (US)
Corresponding author: Manji, Husseini K.
ORCID: Du, Jing
Manji, Husseini K.
Venue: The International Journal of Neuropsychopharmacology
Publisher: Oxford University Press (OUP)
Published: 2009-02-19
Volume: 12
Issue: 04
Pages: 561
ISSN: 1461-1457 (ISSN-L)
1469-5111
DOI: 10.1017/s1461145709009924
PMC: PMC2771334
OpenAlex: W2164978865
Cited by: 350
References: 212
Citations by year: 2026: 14 · 2025: 16 · 2024: 22 · 2023: 25 · 2022: 18 · 2021: 29 · 2020: 22 · 2019: 23 · 2018: 17 · 2017: 20 · 2016: 20 · 2015: 19 · 2014: 27 · 2013: 14 · 2012: 23
FWCI: 0.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The International Journal of Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services
National Institutes of Health
National Institute of Mental Health (Z01MH002835)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: major depressive disorder, inflammatory cytokines, synaptic plasticity, TNF-α, interleukin-1, neuroinflammation, cognitive impairment, treatment resistance, anti-inflammatory therapy, antidepressants
MeSH terms: Animals, Antidepressive Agents, Brain Chemistry, Depressive Disorder, Major, Major Depressive Disorder, Humans, Neuronal Plasticity, Cytokines, Mood Disorders

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A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

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