A double dissociation within the hippocampus of dopamine D1/D5 receptor and β-adrenergic receptor contributions to the persistence of long-term potentiation

Swanson-Park, J.L; Coussens, C.M; Mason-Parker, S.E; Raymond, C.R; Hargreaves, E.L; Dragunow, M; Cohen, A.S; Abraham, W.C

doi:10.1016/s0306-4522(99)00010-x

Cited by 175Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

A double dissociation within the hippocampus of dopamine D1/D5 receptor and β-adrenergic receptor contributions to the persistence of long-term potentiation

Swanson-Park, J.L, Coussens, C.M, Mason-Parker, S.E, Raymond, C.R, Hargreaves, E.L, Dragunow, M, Cohen, A.S, Abraham, W.C·1999·Neuroscience

DOI 10.1016/s0306-4522(99)00010-x

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Abstract

We compared the effects of the D1/D5 receptor antagonist SCH-23390 with the beta-adrenergic receptor antagonist propranolol on the persistence of long-term potentiation in the CA1 and dentate gyrus subregions of the hippocampus. In slices, SCH-23390 but not propranolol reduced the persistence of long-term potentiation in area CA1 without affecting its induction. The drugs exerted reverse effects in the dentate gyrus, although in this case the induction of long-term potentiation was also affected by propranolol. The lack of effect of SCH-23390 on the induction and maintenance of long-term potentiation in the dentate gyrus was confirmed in awake animals. The drug also had little or no effect on the expression of inducible transcription factors. In area CA1 of awake animals, SCH-23390 blocked persistence of long-term potentiation beyond 3 h, confirming the results in slices. To rule out a differential release of catecholamines induced by our stimulation protocols between brain areas, we compared the effects of the D1/D5 agonist SKF-38393 with the beta-adrenergic agonist isoproterenol on the persistence of a weakly induced, decremental long-term potentiation in CA1 slices. SKF-38393 but not isoproterenol promoted greater persistence of long-term potentiation over a 2-h period. In contrast, isoproterenol but not SKF-38392 facilitated the induction of long-term potentiation. These data demonstrate that there is a double dissociation of the catecholamine modulation of long-term potentiation between CA1 and the dentate gyrus, suggesting that long-term potentiation in these brain areas may be differentially consolidated according to the animal's behavioural state.

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The D1-like antagonist SCH does not block early LTP produced by tetanization, but does block late phase LTP.
“The D1-like antagonist, SCH, does not block early LTP produced by tetanization, but does block late phase LTP (Swanson-Park et al., 1999).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Swanson-Park et al., 1999

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Authors: Swanson-Park, J. L., Coussens, C. M., Mason-Parker, S. E., Raymond, C. R., Hargreaves, E. L., Dragunow, M., Cohen, A. S., & Abraham, W. C.
Affiliations: University of Otago (NZ)
University of Auckland (NZ)
Corresponding author: Abraham, W.C
ORCID: Hargreaves, E.L
Dragunow, M
Cohen, A.S
Abraham, W.C
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1999-05
Volume: 92
Issue: 2
Pages: 485-497
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/s0306-4522(99)00010-x
OpenAlex: W1992084781
Cited by: 175
References: 45
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 12 · 2013: 15 · 2012: 9
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: long-term potentiation, dopamine D1/D5 receptors, beta-adrenergic receptors, hippocampus, CA1, dentate gyrus, SCH 23390, propranolol, SKF 38393, isoproterenol, synaptic consolidation, behavioral state
MeSH terms: Adrenergic beta-Antagonists, Animals, Benzazepines, Hippocampus, Male, Propranolol, Receptors, Adrenergic, beta, Rats, Sprague-Dawley, Receptors, Dopamine D1, Long-Term Potentiation, Dopamine Antagonists, Excitatory Postsynaptic Potentials, Receptors, Dopamine D5, Rats

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A double dissociation within the hippocampus of dopamine D1/D5 receptor and β-adrenergic receptor contributions to the persistence of long-term potentiation

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