Change in the Brain's White Matter
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The role of the brain's white matter in active learning and memory may be underestimated.
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Myelin damage could impair neuroplasticity and skilled motor learning and thereby contribute to cognitive impairment.
“In addition, since myelination of previously naked fibers participates in neuroplasticity and skilled motor learning (Fields, 2010; Richardson et al., 2011), myelin damage could also compromise these important functions and contribute to cognitive impairment.”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Fields, 2010
Neuronal activity-dependent myelination changes have been observed in cell culture and in vivo experiments.
“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Fields, 2010
The gray-value of the highest histogram bin typically corresponds to the gray-value of the white matter.
“As almost half of the brain is the whiter matter (Fields, 2010), the gray-value of the highest histogram bin typically corresponds to the gray-value of the white matter”
From A deep learning model integrating FCNNs and CRFs for brain tumor segmentation (2018) · cites this paper as Fields, 2010
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Cites
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“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
BackgroundWhite matter maturation profiles through early childhood predict general cognitive ability
Deoni, S. C. L., O’Muircheartaigh, J., Elison, J. T., Walker, L., Doernberg, E., Waskiewicz, N., Dirks, H., Piryatinsky, I., Dean, D. C., & Jumbe, N. L. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0947-x · Cited by 147 · see citing works
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Baboons (Papio anubis) living in larger social groups have bigger brains.
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- Authors
- Fields, R. D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fields, R. Douglas
- ORCID
- Fields, R. Douglas
- Venue
- Science
- Published
- 2010-11-05
- Volume
- 330
- Issue
- 6005
- Pages
- 768-769
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3201847
- OpenAlex
- W2107409571
- Cited by
- 265
- References
- 18
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 27 · 2023: 18 · 2022: 18 · 2021: 15 · 2020: 13 · 2019: 20 · 2018: 12 · 2017: 21 · 2016: 18 · 2015: 15 · 2014: 15 · 2013: 17 · 2012: 12
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD000713)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- white matter, neuroplasticity, learning, memory, neuronal connectivity
- MeSH terms
- Adenosine Triphosphate, Animals, Axons, Brain, Electric Stimulation, Humans, Learning, Magnetic Resonance Imaging, Memory, Myelin Sheath, Synaptic Transmission, Oligodendroglia, Stem Cells, Synapses
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