Prenatal exposure to per-and polyfluoroalkyl substances (PFASs) and association between the placental transfer efficiencies and dissociation constant of serum proteins–PFAS complexes
Abstract
Information on placental transfer and adverse outcomes of short-chain per- and polyfluoroalkyl substance (PFASs) is limited, and factors responsible for PFAS placental transfer are still unclear. In the present study, concentrations of 21 PFASs were analyzed in 132 paired maternal and cord serum samples collected from residents in Beijing, China, and the placental transfer efficiency (PTE) of each PFAS was calculated. PTEs of short-chain perfluoroalkyl acids (PFAAs), including PFBA (146%), PFBS (97%), PFPeA (118%), and PFHxA (110%), were first reported, and a complete U-shaped trend of PTEs from C4 to C13 of perfluoroalkyl carboxylic acids (PFCAs) was obtained. Positive association between maternal weight and PTE of perfluorooctanesulfonate (PFOS) ( p < 0.05) and negative association between maternal PFBA concentration and birth length ( p < 0.01) were observed. Using in vitro experiments, we further determined equilibrium dissociation constants ( K d s) of human serum albumin (HSA)–PFAS complexes ( K d-HP ), serum proteins–PFAS complexes ( K d-SP ), and liver-fatty acid binding protein (L-FABP)–PFAS complexes ( K d-LP ) and found that they were all significantly correlated with PTEs of PFASs. The correlation coefficient was 0.92, 0.89, and 0.86, respectively ( p < 0.01 in all three tests), suggesting that K d s of protein (serum)–PFAS complexes can play an important role in trans-placental transfer of PFASs in human and K d-HP plays a pivotal role.
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Gao et al. observed that short-chain PFASs, such as PFBA and PFHpA, had more pronounced negative effects on birth weight and length when detected in both maternal and cord blood, compared to long-chain PFASs.
“Gao et al. [209] observed that short-chain PFASs, such as PFBA and PFHpA, had more pronounced negative effects on birth weight and length when detected in both maternal and cord blood, compared to long-chain PFASs.”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [209]
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- Authors
- Gao, K., Zhuang, T., Liu, X., Fu, J., Zhang, J., Fu, J., Wang, L., Zhang, A., Liang, Y., Song, M., & Jiang, G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Capital Medical University (CN)
- Jianghan University (CN)
- Corresponding author
- Fu, Jianjie
- ORCID
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-05-17
- Volume
- 53
- Issue
- 11
- Pages
- 6529-6538
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2944857720
- Cited by
- 231
- References
- 73
- Citations by year
- 2026: 37 · 2025: 39 · 2024: 35 · 2023: 31 · 2022: 31 · 2021: 28 · 2020: 26 · 2019: 4
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018052)
- National Natural Science Foundation of China (21477154, 21607168, 91743204)
- Chinese Academy of Sciences (XDB14030500)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- per- and polyfluoroalkyl substances, PFAS, prenatal exposure, PFOS, liver fatty acid binding protein, equilibrium dissociation constant, birth length, maternal weight, cord serum, maternal serum
- MeSH terms
- Beijing, Blood Proteins, China, Female, Fluorocarbons, Humans, Pregnancy, Prenatal Exposure Delayed Effects
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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