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Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy
Abstract
Cell therapy is a promising strategy to regenerate cardiac tissue for myocardial infarction. Injectable hydrogels with conductivity and self-healing ability are highly desirable as cell delivery vehicles for cardiac regeneration. Here, we developed self-healable conductive injectable hydrogels based on chitosan-graft-aniline tetramer (CS-AT) and dibenzaldehyde-terminated poly(ethylene glycol) (PEG-DA) as cell delivery vehicles for myocardial infarction. Self-healed electroactive hydrogels were obtained after mixing CS-AT and PEG-DA solutions at physiological conditions. Rapid self-healing behavior was investigated by rheometer. Swelling behavior, morphology, mechanical strength, electrochemistry, conductivity, adhesiveness to host tissue and antibacterial property of the injectable hydrogels were fully studied. Conductivity of the hydrogels is ∼10(-3) S·cm(-1), which is quite close to native cardiac tissue. Proliferation of C2C12 myoblasts in the hydrogel showed its good biocompatibility. After injection, viability of C2C12 cells in the hydrogels showed no significant difference with that before injection. Two different cell types were successfully encapsulated in the hydrogels by self-healing effect. Cell delivery profile of C2C12 myoblasts and H9c2 cardiac cells showed a tunable release rate, and in vivo cell retention in the conductive hydrogels was also studied. Subcutaneous injection and in vivo degradation of the hydrogels demonstrated their injectability and biodegradability. Together, these self-healing conductive biodegradable injectable hydrogels are excellent candidates as cell delivery vehicle for cardiac repair.
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Cites
Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
Goossens, H., Ferech, M., Vander Stichele, R., & Elseviers, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17907-0 · Cited by 3,359
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Hager, M. D., Greil, P., Leyens, C., van der Zwaag, S., & Schubert, U. S. (2010) · Advanced Materials · doi:10.1002/adma.201003036 · Cited by 1,238
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
Miyahara, Y., Nagaya, N., Kataoka, M., Yanagawa, B., Tanaka, K., Hao, H., Ishino, K., Ishida, H., Shimizu, T., Kangawa, K., et al. (2006) · Nature Medicine · doi:10.1038/nm1391 · Cited by 1,193
Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation
Taylor, D. A., Atkins, B. Z., Hungspreugs, P., Jones, T. R., Reedy, M. C., Hutcheson, K. A., Glower, D. D., & Kraus, W. E. (1998) · Nature Medicine · doi:10.1038/nm0898-929 · Cited by 1,152
Self-healing materials: a review
Wool, R. P. (2008) · Soft Matter · doi:10.1039/b711716g · Cited by 1,033
Alt, V., Bechert, T., Steinrücke, P., Wagener, M., Seidel, P., Dingeldein, E., Domann, E., & Schnettler, R. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.078 · Cited by 952
Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators
Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., et al. (2013) · ACS Nano · doi:10.1021/nn305559j · Cited by 946
Zhang, Y., Tao, L., Li, S., & Wei, Y. (2011) · Biomacromolecules · doi:10.1021/bm200423f · Cited by 670
Granzier, H. L., & Irving, T. C. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80278-x · Cited by 640
Synthetic biodegradable functional polymers for tissue engineering: a brief review
Guo, B., & Ma, P. X. (2014) · Science China Chemistry · doi:10.1007/s11426-014-5086-y · Cited by 592
Self-citationBiodegradable and electrically conducting polymers for biomedical applications
Guo, B., Glavas, L., & Albertsson, A.-C. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.06.003 · Cited by 592
Self-citationMathur, A. B., Collinsworth, A. M., Reichert, W. M., Kraus, W. E., & Truskey, G. A. (2001) · Journal of Biomechanics · doi:10.1016/s0021-9290(01)00149-x · Cited by 589
An Injectable, Self‐Healing Hydrogel to Repair the Central Nervous System
Tseng, T., Tao, L., Hsieh, F., Wei, Y., Chiu, I., & Hsu, S. (2015) · Advanced Materials · doi:10.1002/adma.201500762 · Cited by 581
Zhao, X., Li, P., Guo, B., & Ma, P. X. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.006 · Cited by 570
Self-citationShin, J., Lee, J. S., Lee, C., Park, H., Yang, K., Jin, Y., Ryu, J. H., Hong, K. S., Moon, S., Chung, H., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500006 · Cited by 432
A Self‐Healing Poly(Dimethyl Siloxane) Elastomer
Keller, M. W., White, S. R., & Sottos, N. R. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200700086 · Cited by 419
Wang, L., Wu, Y., Guo, B., & Ma, P. X. (2015) · ACS Nano · doi:10.1021/acsnano.5b03644 · Cited by 381
Self-citationSchiff's base as a stimuli-responsive linker in polymer chemistry
Xin, Y., & Yuan, J. (2012) · Polymer Chemistry · doi:10.1039/c2py20290e · Cited by 369
Cell Delivery Mechanisms for Tissue Repair
Mooney, D. J., & Vandenburgh, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.005 · Cited by 357
Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts
Bidez, P. R., Li, S., MacDiarmid, A. G., Venancio, E. C., Wei, Y., & Lelkes, P. I. (2006) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856206774879180 · Cited by 330
Wu, Y., Wang, L., Guo, B., Shao, Y., & Ma, P. X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.010 · Cited by 322
Self-citationA Single Component Conducting Polymer Hydrogel as a Scaffold for Tissue Engineering
Mawad, D., Stewart, E., Officer, D. L., Romeo, T., Wagner, P., Wagner, K., & Wallace, G. G. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201102373 · Cited by 285
Serena, E., Figallo, E., Tandon, N., Cannizzaro, C., Gerecht, S., Elvassore, N., & Vunjak-Novakovic, G. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.08.015 · Cited by 269
Polypyrrole‐contained electrospun conductive nanofibrous membranes for cardiac tissue engineering
Kai, D., Prabhakaran, M. P., Jin, G., & Ramakrishna, S. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33200 · Cited by 257
Zheng, F., Wang, S., Wen, S., Shen, M., Zhu, M., & Shi, X. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.071 · Cited by 255
Broad spectrum antimicrobial activity of functionalized polyanilines
Gizdavic-Nikolaidis, M. R., Bennett, J. R., Swift, S., Easteal, A. J., & Ambrose, M. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.07.018 · Cited by 224
Gharibi, R., Yeganeh, H., Rezapour-Lactoee, A., & Hassan, Z. M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b08376 · Cited by 205
Xie, M., Wang, L., Ge, J., Guo, B., & Ma, P. X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00191 · Cited by 201
Self-citationDrug and cell delivery for cardiac regeneration
Hastings, C. L., Roche, E. T., Ruiz-Hernandez, E., Schenke-Layland, K., Walsh, C. J., & Duffy, G. P. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.08.006 · Cited by 200
Song, A., Rane, A. A., & Christman, K. L. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.10.004 · Cited by 184
ANDERSON, R. H., Durrer, D., JANSE, M. J., VAN CAPELLE, F. J. L., BILLETE, J., BECKER, A. E., & DURRER, D. (1974) · Circulation Research · doi:10.1161/01.res.35.6.909 · Cited by 170
Baheiraei, N., Yeganeh, H., Ai, J., Gharibi, R., Azami, M., & Faghihi, F. (2014) · Materials Science and Engineering: C · doi:10.1016/j.msec.2014.07.061 · Cited by 168
Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart
Kudo, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00211-6 · Cited by 168
Wang, H., Shi, J., Wang, Y., Yin, Y., Wang, L., Liu, J., Liu, Z., Duan, C., Zhu, P., & Wang, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.021 · Cited by 164
Chen, J., Dong, R., Ge, J., Guo, B., & Ma, P. X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b10829 · Cited by 160
Self-citationNovel antibacterial nanofibrous PLLA scaffolds
Feng, K. M., Sun, H., Bradley, M. A., Dupler, E. J., Giannobile, W. V., & Ma, P. X. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.05.035 · Cited by 141
Self-citationGuo, B., Sun, Y., Finne‐Wistrand, A., Mustafa, K., & Albertsson, A. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.09.027 · Cited by 122
Self-citationIn situ forming biodegradable electroactive hydrogels
Li, L., Ge, J., Guo, B., & Ma, P. X. (2013) · Polymer Chemistry · doi:10.1039/c3py01634j · Cited by 122
Self-citationYang, B., Yao, F., Hao, T., Fang, W., Ye, L., Zhang, Y., Wang, Y., Li, J., & Wang, C. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500520 · Cited by 116
Cui, H., Shao, J., Wang, Y., Zhang, P., Chen, X., & Wei, Y. (2013) · Biomacromolecules · doi:10.1021/bm4002766 · Cited by 115
Xie, M., Wang, L., Guo, B., Wang, Z., Chen, Y., & Ma, P. X. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.042 · Cited by 112
Self-citationLiu, Q., Tian, S., Zhao, C., Chen, X., Lei, I., Wang, Z., & Ma, P. X. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.017 · Cited by 111
Self-citationZhang, Q., Yan, Y., Li, S., & Feng, T. (2009) · Materials Science and Engineering C · doi:10.1016/j.msec.2009.09.013 · Cited by 105
Barker, P. C. A., Houle, H., Li, J. S., Miller, S. P., Herlong, J. R., & Camitta, M. G. W. (2008) · Echocardiography · doi:10.1111/j.1540-8175.2008.00761.x · Cited by 98
Wu, Y., Wang, L., Guo, B., & Ma, P. X. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21716g · Cited by 94
Self-citationA novel polyurethane/cellulose fibrous scaffold for cardiac tissue engineering
Chen, P.-H., Liao, H., Hsu, S., Chen, R., Wu, M., Yang, Y., Wu, C., Chen, M., & Su, W. (2014) · RSC Advances · doi:10.1039/c4ra12486c · Cited by 91
Cui, H., Cui, L., Zhang, P., Huang, Y., Wei, Y., & Chen, X. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201300366 · Cited by 88
Ma, X., Ge, J., Li, Y., Guo, B., & Ma, P. X. (2014) · RSC Advances · doi:10.1039/c4ra00083h · Cited by 75
Self-citationGiraud, M., Ayuni, E., Cook, S., Siepe, M., Carrel, T. P., & Tevaearai, H. T. (2008) · Artificial Organs · doi:10.1111/j.1525-1594.2008.00595.x · Cited by 74
Suzuki, K., Murtuza, B., Fukushima, S., Smolenski, R. T., Varela‐Carver, A., Coppen, S. R., & Yacoub, M. H. (2004) · Circulation · doi:10.1161/01.cir.0000138191.11580.e3 · Cited by 73
Supramolecular Hydrogels for Long‐Term Bioengineered Stem Cell Therapy
Yeom, J., Kim, S. J., Jung, H., Namkoong, H., Yang, J., Hwang, B. W., Oh, K., Kim, K., Sung, Y. C., & Hahn, S. K. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400304 · Cited by 73
Antibacterial properties of polyaniline-silver films
Kuceková, Z., Kašpárková, V., Humpolíček, P., Sevcikova, P., & Stejskal, J. (2013) · Chemical Papers · doi:10.2478/s11696-013-0385-x · Cited by 69
Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium
Nam, H. Y., McGinn, A. N., Kim, P., Kim, S. W., & Bull, D. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.025 · Cited by 68
Woo, D. G., Shim, M. S., Park, J. S., Yang, H. N., Lee, D.-R., & Park, K.-H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.026 · Cited by 65
Genetically Engineered Chimeric Silk–Silver Binding Proteins
Currie, H. A., Deschaume, O., Naik, R. R., Perry, C. C., & Kaplan, D. L. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201100249 · Cited by 65
A combined electrophysiological and anatomical study of the human fetal heart
Janse, M. J., Anderson, R. H., van Capelle, F. J. L., et al. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80139-1 · Cited by 58
Pouzet, B., Ghostine, S., Vilquin, J., Garcin, I., Scorsin, M., Hagège, A. A., Duboc, D., Schwartz, K., & Menasché, P. (2001) · Circulation · doi:10.1161/circ.104.suppl_1.i-223 · Cited by 57
Li, L., Yu, M., Ma, P. X., & Guo, B. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01899d · Cited by 56
Self-citationKotanen, C. N., Wilson, A. N., Dong, C., Dinu, C.-Z., Justin, G. A., & Guiseppi‐Elie, A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.022 · Cited by 55
Guo, B., Yuan, J., & Gao, Q. (2007) · Colloid & Polymer Science · doi:10.1007/s00396-007-1749-y · Cited by 50
Self-citationIn vitro dielectric properties of human tissues at radiofrequencies
Surowiec, A., Stuchly, S. S., Eidus, L. K., et al. (1987) · Physics in Medicine and Biology · doi:10.1088/0031-9155/32/5/007 · Cited by 49
Liu, X., Song, L. Y., Li, L., Li, S., & Yao, K. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.25421 · Cited by 45
Zhao, X., Guo, B., & Ma, P. X. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01658d · Cited by 37
Self-citationWei, H., Ooi, T. H., TAN, G. M. Y., Lim, S. Y., Qian, L., Wong, P., & SHIM, W. S. N. (2009) · Heart Failure Reviews · doi:10.1007/s10741-009-9134-1 · Cited by 36
Hong, S. J., Rogers, P. I., Kihlken, J., Warfel, J., Bull, C., Deuter‐Reinhard, M., Feng, D., Xie, J., Kyle, A. M., Merfeld‐Clauss, S., et al. (2014) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.25566 · Cited by 21
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Metadata
- Authors
- Dong, R., Zhao, X., Guo, B., & Ma, P. X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-06-27
- Volume
- 8
- Issue
- 27
- Pages
- 17138-17150
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2438540806
- Cited by
- 538
- References
- 66
- FWCI
- 26.52
- Type
- journal article
- Language
- en
- Open access
- closed
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