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Cited by 10Insect Pest Control StrategiesPlant biochemistry and biosynthesisBioactive Natural Diterpenoids Research

Phytoecdysteroid and Clerodane Content in Three Wild Ajuga Species in Israel

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Taha-Salaime, Leena, Davidovich-Rikanati, Rachel, Sadeh, Asaf, Abu-Nassar, Jackline, Marzouk-Kheredin, Sally, Yahyaa, Yahyaa, Ibdah, Mwafaq, Ghanim, Murad +3 more·2019·ACS Omega
DOI 10.1021/acsomega.8b03029
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Abstract

Abstract Many species of the genus Ajuga (family Lamiaceae) contain phytoecdysteroids and clerodane diterpenes. Phytoecdysteroids are triterpene-derived analogues of steroid hormones that control molting and metamorphosis in arthropods, whereas clerodanes deter phytophagous insects. We identified and quantified phytoecdysteroid and clerodane contents in three Ajuga plant species in Israel. Leaves and roots of Ajuga iva, Ajuga chamaepitys (Ajuga chia), and Ajuga orientalis were collected from three different populations. Using liquid chromatography–time of flight–mass spectrometry analysis, we identified three phytoecdysteroids: 20-hydroxyecdysone (ecdysterone), makisterone A, and cyasterone and two clerodanes: dihydroajugapitin and columbin. Their contents varied significantly among plant species, organs, and populations. The highest concentrations of 20-hydroxyecdysone, makisterone A, and cyasterone were recorded in leaves and roots of A. iva. Cyasterone content tended to be higher in leaves of A. chamaepitys. Clerodane concentrations were generally negligible or nonexistent. Dihydroajugapitin concentrations were highest in A. iva leaves but were lower or undetectable in the roots and in the other two species. Columbin concentration was similar in all species and organs. Phytoecdysteroid contents also varied among populations within species. Because phytoecdysteroids have disruptive effects on phytophagous insect growth, the potential role of extracts of A. iva in pest-management programs is of interest.

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  • Based on liquid chromatography-time of flight-mass spectrometry analysis, PEs can be found in large quantities in leaves and roots of genus Ajuga; thus, its extract can be used to control phytophagous insect growth in pest-management programs.

    “Based on liquid chromatography–time of flight–mass spectrometry analysis, PEs can be found in large quantities in leaves and roots of genus Ajuga; thus, its extract can be used to control phytophagous insect growth in pest-management programs [196].”

    From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [196]

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Authors
Taha-Salaime, L., Davidovich-Rikanati, R., Sadeh, A., Abu-Nassar, J., Marzouk-Kheredin, S., Yahyaa, Y., Ibdah, M., Ghanim, M., Lewinsohn, E., Inbar, M., & Aly, R.
Affiliations
  • Agricultural Research Organization (IL)
  • Agricultural Research Organization , , ,
  • University of Haifa (IL)
Corresponding author
Aly, Radi
ORCID
Venue
ACS Omega
Publisher
American Chemical Society (ACS)
Published
2019-01-31
Volume
4
Issue
1
Pages
2369-2376
ISSN
2470-1343 (ISSN-L)
DOI
10.1021/acsomega.8b03029
OpenAlex
W2912106347
Cited by
10
References
62
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Omega (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Science, Technology and Space (3-14496)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
Keywords
phytoecdysteroids, clerodane diterpenoids, Ajuga iva, Ajuga chamaepitys, Ajuga orientalis, 20-hydroxyecdysone, makisterone A, cyasterone, columbin, triterpenoids, plant-insect interactions, pest control, Lamiaceae

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