The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
Open accessAbstract
A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the NCl for enhanced loading capacity of the anticancer drug doxorubicin (DOX). Meanwhile, negatively charged DNase I was encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl by electrostatic interactions. In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy.
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Metadata
- Authors
- Sun, W., Jiang, T., Lu, Y., Reiff, M., Mo, R., & Gu, Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-10-13
- Volume
- 136
- Issue
- 42
- Pages
- 14722-14725
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2027107554
- Cited by
- 329
- References
- 27
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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