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Ultrasmall c(RGDyK)-Coated Fe 3 O 4 Nanoparticles and Their Specific Targeting to Integrin α v β 3 -Rich Tumor Cells
Open accessAbstract
We report a direct synthesis of ultrasmall c(RGDyK) peptide-coated Fe3O4 NPs (<10 nm in hydrodynamic diameter) and demonstrate their in vivo tumor-specific targeting capability. The Fe3O4 NPs are synthesized by thermal decomposition of iron pentacarbonyl in the presence of 4-methylcatechol (4-MC), and the peptide is coupled to the nanoparticles through 4-MC via Mannich reaction. The c(RGDyK)-MC-Fe3O4 NPs have an overall diameter of approximately 8.4 nm and are stable in physiological conditions. When administrated intravenously, these c(RGDyK)-MC-Fe3O4 NPs accumulate preferentially in the integrin alphavbeta3-rich tumor area, which are readily tracked by MRI.
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Metadata
- Authors
- Xie, J., Chen, K., Lee, H.-Y., Xu, C., Hsu, A. R., Peng, S., Chen, X., & Sun, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-24
- Volume
- 130
- Issue
- 24
- Pages
- 7542-7543
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1990579572
- Cited by
- 419
- References
- 15
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- green
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