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Physiologically Based Pharmacokinetic Modeling of Nanoparticles
Abstract
Rapid expansion of nanoparticle research demands new technologies that will enable better interpretation of experimental data and assistance in the rational design of future nanoparticles. The use of physiologically based pharmacokinetic (PBPK) models may serve as powerful tools to meet these needs. PBPK models have been successfully applied for the study of the absorption, distribution, metabolism, and excretion (ADME) of small molecules, such as drugs. Preliminary application of PBPK models to nanoparticles illustrated their potential usefulness for nanoparticle ADME research. However, due to the differences between nanoparticles and small molecules, modifications are needed to build appropriate PBPK models for nanoparticles. This review is divided into two sections, with the first discussing nanoparticle ADME research, emphasizing the interaction of nanoparticles with living systems, including transportation kinetics across biobarriers. In the second section, the basic principles of PBPK model development are introduced, and research pertaining to PBPK models of nanoparticles is reviewed. Factors that need to be considered for developing PBPK models for nanoparticles are also discussed. Finally, perspective applications of nanoparticle PBPK models are summarized.
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Citations
Cites
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 1×
“Tumor blood vessels are leaky, tortuous, and dilated, and their endothelial cells lining have aberrant morphology with the basement membrane often being abnormal.(64) Their high vascular density, vascular leakiness, and impaired lymphatic recovery lead to an enhanced permeability and retention (EPR) effect for nanopar…”
BackgroundIn vivo cancer targeting and imaging with semiconductor quantum dots
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,772
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,805
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637
Nanoparticles in cancer therapy and diagnosis
Brigger, I., Dubernet, C., & Couvreur, P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00044-3 · Cited by 3,039
Physiological Parameters in Laboratory Animals and Humans
Davies, B., & Morris, T. (1993) · Pharmaceutical Research · doi:10.1023/a:1018943613122 · Cited by 2,926
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Nanoengineering of Particle Surfaces
Caruso, F. (2001) · Advanced Materials · doi:10.1002/1521-4095(200101)13:1<11::aid-adma11>3.0.co;2-n · Cited by 2,475
Nanoparticle and targeted systems for cancer therapy
Brannon-Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,334
Chithrani, B. D., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,286
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,815
Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791
Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,687
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,615
PEGylated nanoparticles for biological and pharmaceutical applications
Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,588
Yin Win, K., & Feng, S.-S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.07.050 · Cited by 1,452
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Liu, Z., Cai, W., He, L., Nakayama, N., Chen, K., Sun, X., Chen, X., & Dai, H. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2006.170 · Cited by 1,436
Determinants of tumor blood flow: a review.
Jain, R. K. (1988) · PubMed · Cited by 1,379
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O'Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,350
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
In vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice
Liu, Z., Cai, W., He, L., Nakayama, N., Chen, K., Sun, X., Chen, X., & Dai, H. (2020) · Nano-Enabled Medical Applications · doi:10.1201/9780429399039-14 · Cited by 1,213
Translocation of Inhaled Ultrafine Manganese Oxide Particles to the CentralNervous System
Elder, A., Gelein, R., Silva, V., Feikert, T., Opanashuk, L., Carter, J., Potter, R., Maynard, A., Ito, Y., Finkelstein, J., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9030 · Cited by 1,180
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
Size‐Dependent Endocytosis of Nanoparticles
Zhang, S., Li, J., Lykotrafitis, G., Bao, G., & Suresh, S. (2009) · Advanced Materials · doi:10.1002/adma.200801393 · Cited by 1,059
Singh, R., Pantarotto, D., Lacerda, L., Pastorin, G., Klumpp, C., Prato, M., Bianco, A., & Kostarelos, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509009103 · Cited by 1,043
Self-citationOberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., & Cox, C. (2002) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/00984100290071658 · Cited by 846
Hillyer, J. F., & Albrecht, R. M. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1143 · Cited by 706
Hussain, N. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00152-1 · Cited by 680
Inhaled nanoparticles—A current review
Yang, W., Peters, J. I., & Williams, R. O. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.02.011 · Cited by 666
NEMMAR, A., VANBILLOEN, H., HOYLAERTS, M. F., HOET, P. H. M., VERBRUGGEN, A., & NEMERY, B. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2101036 · Cited by 643
Antibacterial effect of nanosized silver colloidal solution on textile fabrics
Lee, H. J., Yeo, S. Y., & Jeong, S. H. (2003) · Journal of Materials Science · doi:10.1023/a:1023736416361 · Cited by 615
Kupffer cells are central in the removal of nanoparticles from the organism
Sadauskas, E., Wallin, H., Stoltenberg, M., Vogel, U., Doering, P., Larsen, A., & Danscher, G. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-10 · Cited by 607
Physiologically Based Pharmacokinetic Modeling: Principles and Applications
Gerlowski, L. E., & Jain, R. K. (1983) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600721003 · Cited by 576
Interaction of Nanoparticles with Cells
Mailänder, V., & Landfester, K. (2009) · Biomacromolecules · doi:10.1021/bm900266r · Cited by 576
Sheddable Coatings for Long-Circulating Nanoparticles
Romberg, B., Hennink, W. E., & Storm, G. (2008) · Pharmaceutical Research · doi:10.1007/s11095-007-9348-7 · Cited by 555
Kumar, R., Roy, I., Ohulchanskky, T. Y., Vathy, L. A., Bergey, E. J., Sajjad, M., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn901146y · Cited by 548
Rothen-Rutishauser, B. M., Schürch, S., Haenni, B., Kapp, N., & Gehr, P. (2006) · Environmental Science & Technology · doi:10.1021/es0522635 · Cited by 534
The kinetics of the tissue distribution of silver nanoparticles of different sizes
Lankveld, D. P. K., Oomen, A. G., Krystek, P., Neigh, A., Troost – de Jong, A., Noorlander, C. W., Van Eijkeren, J. C. H., Geertsma, R. E., & De Jong, W. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.045 · Cited by 512
Panyam, J., & Labhasetwar, V. (2003) · Pharmaceutical Research · doi:10.1023/a:1022219003551 · Cited by 466
What do we (need to) know about the kinetic properties of nanoparticles in the body?
Hagens, W. I., Oomen, A. G., de Jong, W. H., Cassee, F. R., & Sips, A. J. A. M. (2007) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2007.07.006 · Cited by 464
Woodrow, K. A., Cu, Y., Booth, C. J., Saucier-Sawyer, J. K., Wood, M. J., & Mark Saltzman, W. (2009) · Nature Materials · doi:10.1038/nmat2444 · Cited by 438
Biodegradation of Single-Walled Carbon Nanotubes through Enzymatic Catalysis
Allen, B. L., Kichambare, P. D., Gou, P., Vlasova, I. I., Kapralov, A. A., Konduru, N., Kagan, V. E., & Star, A. (2008) · Nano Letters · doi:10.1021/nl802315h · Cited by 433
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems
Semete, B., Booysen, L., Lemmer, Y., Kalombo, L., Katata, L., Verschoor, J., & Swai, H. S. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.02.002 · Cited by 425
Toxicological Hazards of Inhaled Nanoparticles—Potential Implications for Drug Delivery
Borm, P. J. A., & Kreyling, W. (2004) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2004.081 · Cited by 419
The uptake and intracellular fate of PLGA nanoparticles in epithelial cells
Cartiera, M. S., Johnson, K. M., Rajendran, V., Caplan, M. J., & Saltzman, W. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.057 · Cited by 412
Yamago, S., Tokuyama, H., Nakamura, E., Kikuchi, K., Kananishi, S., Sueki, K., Nakahara, H., Enomoto, S., & Ambe, F. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90219-8 · Cited by 375
Nanoparticles, human health hazard and regulation
Seaton, A., Tran, L., Aitken, R., & Donaldson, K. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0252.focus · Cited by 350
Arbab, A. S., Wilson, L. B., Ashari, P., Jordan, E. K., Lewis, B. K., & Frank, J. A. (2005) · NMR in Biomedicine · doi:10.1002/nbm.970 · Cited by 347
Sentinel Lymph Node Imaging Using Quantum Dots in Mouse Tumor Models
Ballou, B., Ernst, L. A., Andreko, S., Harper, T., Fitzpatrick, J. A. J., Waggoner, A. S., & Bruchez, M. P. (2007) · Bioconjugate Chemistry · doi:10.1021/bc060261j · Cited by 344
Yang, R. S. H., Chang, L. W., Wu, J.-P., Tsai, M.-H., Wang, H.-J., Kuo, Y.-C., Yeh, T.-K., Yang, C. S., & Lin, P. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10290 · Cited by 314
Griset, A. P., Walpole, J., Liu, R., Gaffey, A., Colson, Y. L., & Grinstaff, M. W. (2009) · Journal of the American Chemical Society · doi:10.1021/ja807416t · Cited by 305
Cho, M., Cho, W.-S., Choi, M., Kim, S. J., Han, B. S., Kim, S. H., Kim, H. O., Sheen, Y. Y., & Jeong, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.04.017 · Cited by 304
Kohli, A. K., & Alpar, H. O. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.10.038 · Cited by 292
Whole Body Pharmacokinetic Models
Nestorov, I. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342100-00002 · Cited by 290
Wilhelm, C., Gazeau, F., Roger, J., Pons, J. N., & Bacri, J.-C. (2002) · Langmuir · doi:10.1021/la0257337 · Cited by 290
Timchalk, C. (2002) · Toxicological Sciences · doi:10.1093/toxsci/66.1.34 · Cited by 285
Wang, Y., Tang, Z., Correa-Duarte, M. A., Pastoriza-Santos, I., Giersig, M., Kotov, N. A., & Liz-Marzán, L. M. (2004) · The Journal of Physical Chemistry B · doi:10.1021/jp048948t · Cited by 270
Hoshino, A., Hanaki, K.-I., Suzuki, K., & Yamamoto, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.185 · Cited by 267
Willmann, S., Höhn, K., Edginton, A., Sevestre, M., Solodenko, J., Weiss, W., Lippert, J., & Schmitt, W. (2007) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-007-9053-5 · Cited by 250
Lymphatic targeting with nanoparticulate system
Nishioka, Y., & Yoshino, H. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00121-6 · Cited by 223
Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles
Panagi, Z., Beletsi, A., Evangelatos, G., Livaniou, E., Ithakissios, D. S., & Avgoustakis, K. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00676-7 · Cited by 215
Computational and Ultrastructural Toxicology of a Nanoparticle, Quantum Dot 705, in Mice
Lin, P., Chen, J.-W., Chang, L. W., Wu, J.-P., Redding, L., Chang, H., Yeh, T.-K., Yang, C. S., Tsai, M.-H., Wang, H.-J., et al. (2008) · Environmental Science & Technology · doi:10.1021/es800254a · Cited by 214
Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles
Videira, M. A., Botelho, M. F., Santos, A. C., Gouveia, L. F., Pedroso de Lima, J. J., & Almeida, A. J. (2002) · Journal of Drug Targeting · doi:10.1080/1061186021000054933 · Cited by 213
Harivardhan Reddy, L., Sharma, R. K., Chuttani, K., Mishra, A. K., & Murthy, R. S. R. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.02.028 · Cited by 212
Zhu, M.-T., Feng, W.-Y., Wang, Y., Wang, B., Wang, M., Ouyang, H., Zhao, Y.-L., & Chai, Z.-F. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn245 · Cited by 211
Avgoustakis, K. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00224-2 · Cited by 211
Lacerda, L., Soundararajan, A., Singh, R., Pastorin, G., Al‐Jamal, K. T., Turton, J., Frederik, P., Herrero, M. A., Li, S., Bao, A., et al. (2008) · Advanced Materials · doi:10.1002/adma.200702334 · Cited by 211
Self-citationBinding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Tassa, C., Duffner, J. L., Lewis, T. A., Weissleder, R., Schreiber, S. L., Koehler, A. N., & Shaw, S. Y. (2010) · Bioconjugate Chemistry · doi:10.1021/bc900438a · Cited by 202
Whole-body physiologically based pharmacokinetic models
Nestorov, I. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.3.2.235 · Cited by 188
Gentile, F., Ferrari, M., & Decuzzi, P. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9423-6 · Cited by 184
Baxter, L. T., Zhu, H. J., Mackensen, D. G., Butler, W. F., & Jain, R. K. (1995) · PubMed · Cited by 180
Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice
Gopee, N. V., Roberts, D. W., Webb, P., Cozart, C. R., Siitonen, P. H., Warbritton, A. R., Yu, W. W., Colvin, V. L., Walker, N. J., & Howard, P. C. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm074 · Cited by 170
Physiologically-based pharmacokinetic simulation modelling
Grass, G. M., & Sinko, P. J. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00013-3 · Cited by 160
What determines glomerular capillary permeability?
Deen, W. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200423577 · Cited by 151
Interspecies scaling and comparisons in drug development and toxicokinetics
Ings, R. M. J. (1990) · Xenobiotica · doi:10.3109/00498259009046839 · Cited by 151
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
Riviere, J. E. (2008) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.24 · Cited by 141
Lumping of Whole-Body Physiologically Based Pharmacokinetic Models
Nestorov, I. A., Aarons, L. J., Arundel, P. A., & Rowland, M. (1998) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1023/a:1023272707390 · Cited by 132
Chiannilkulchai, N., Ammoury, N., Caillou, B., Devissaguet, J. P., & Couvreur, P. (1990) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf02897257 · Cited by 130
Li, X., Li, R., Qian, X., Ding, Y., Tu, Y., Guo, R., Hu, Y., Jiang, X., Guo, W., & Li, R. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.06.016 · Cited by 129
Tumor Targeting of Functionalized Quantum Dot−Liposome Hybrids by Intravenous Administration
Al-Jamal, W. T., Al‐Jamal, K. T., Tian, B., Cakebread, A., Halket, J. M., & Kostarelos, K. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800187d · Cited by 126
Self-citationCathepsin L Digestion of Nanobioconjugates upon Endocytosis
Sée, V., Free, P., Cesbron, Y., Nativo, P., Shaheen, U., Rigden, D. J., Spiller, D. G., Fernig, D. G., White, M., Prior, I. A., et al. (2009) · ACS Nano · doi:10.1021/nn9006994 · Cited by 119
Biodegradation of magnetite dextran nanoparticles in the rat. A histologic and biophysical study.
Okon, E. E., Pouliquen, D., Okon, P., Zv, K., Tp, S., Sg, L., Kudryavtsev, B. N., & JALLET, P. (1994) · PubMed · Cited by 117
Lenaerts, V., Nagelkerke, J. F., van Berkel, T. J. C., et al. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600730730 · Cited by 116
Hofmann, A. F., Molino, G., Milanese, M., & Belforte, G. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110828 · Cited by 114
Yin, Y.-S., Chen, D., Qiao, M., Wei, X., & Hu, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.06.024 · Cited by 109
Kreuter, J., Täuber, U., & Illi, V. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600681129 · Cited by 109
Chitosan nanoparticles for drug delivery to the eye
Paolicelli, P., de la Fuente, M., Sánchez, A., Seijo, B., & Alonso, M. J. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902762818 · Cited by 108
Davda, J. P., Jain, M., Batra, S. K., Gwilt, P. R., & Robinson, D. H. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.023 · Cited by 107
SPION-loaded chitosan–linoleic acid nanoparticles to target hepatocytes
Lee, C., Jeong, H., Kim, S., Kim, E.-M., Kim, D. W., Lim, S. T., Jang, K. Y., Jeong, Y. Y., Nah, J., & Sohn, M. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.12.021 · Cited by 107
Thompson, C. M., Johns, D. O., Sonawane, B. R., et al. (2008) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400802545060 · Cited by 101
Exposure, Uptake, Distribution and Toxicity of Nanomaterials in Humans
Holgate, S. T. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1098 · Cited by 101
Translational considerations for cancer nanomedicine
Stern, S. T., Hall, J. B., Yu, L. L., Wood, L. J., Paciotti, G. F., Tamarkin, L., Long, S. E., & McNeil, S. E. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.008 · Cited by 99
Lipinski, M. J., Frias, J. C., Amirbekian, V., Briley-Saebo, K. C., Mani, V., Samber, D. D., Abbate, A., Aguinaldo, J. G. S., Massey, D. H., Fuster, V., et al. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.08.009 · Cited by 96
Sarlo, K. T., Blackburn, K. L., Clark, E. D., Grothaus, J., Chaney, J., Neu, S. M., Flood, J. A., Abbott, D., Bohne, C., Casey, K., et al. (2009) · Toxicology · doi:10.1016/j.tox.2009.07.002 · Cited by 93
Yuan, H., & Zhang, S. (2010) · Applied Physics Letters · doi:10.1063/1.3293303 · Cited by 91
Garza‐Ocañas, L., Ferrer, D. A., Burt, J. L., Diaz-Torres, L. A., Cabrera, M. R., Rodríguez, V. T., Rangel, R. L., Romanovicz, D. K., & José–Yacamán, M. (2009) · Metallomics · doi:10.1039/b916107d · Cited by 88
Péry, A. R. R., Brochot, C., Hoet, P., Nemmar, A., & Bois, F. Y. (2009) · Inhalation Toxicology · doi:10.3109/08958370902748542 · Cited by 85
The migration of bronchoalveolar macrophages into hilar lymph nodes.
Corry, D. B., Kulkarni, P. V., & Lipscomb, M. F. (1984) · PubMed · Cited by 79
Lin, J., Sugiyama, Y., Awazu, S., & Hanano, M. (1982) · Journal of pharmacokinetics and biopharmaceutics · doi:10.1007/bf01062545 · Cited by 79
Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats
Maincent, P., Thouvénot, P., Amicabile, C., Hoffman, M., Kreuter, J., Couvreur, P., & Devissaguet, J. P. (1992) · Pharmaceutical Research · doi:10.1023/a:1015895804597 · Cited by 76
Moghimi, S. M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00273-4 · Cited by 72
Cho, C.-S., Kobayashi, A., Takei, R., Ishihara, T., Maruyama, A., & Akaike, T. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00143-5 · Cited by 69
Binding and Uptake of Wheat Germ Agglutinin-Grafted PLGA-Nanospheres by Caco-2 Monolayers
Weissenböck, A., Bogner, E., Wirth, M., & Gabor, F. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000045247.09724.26 · Cited by 61
Simon, B. H., Ando, H. Y., & Gupta, P. K. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600841020 · Cited by 59
Splenic Trapping of Nanoparticles: Complementary Approaches for In Situ Studies
Demoy, M., Gibaud, S., Andreux, J. P., Weingarten, C., Gouritin, B., & Couvreur, P. (1997) · Pharmaceutical Research · doi:10.1023/a:1012095431931 · Cited by 58
LIAO, C., Chiang, Y.-Y., & Chio, C. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.09.028 · Cited by 53
Liao, C., Liang, H., Chen, B., Singh, S., Tsai, J., Chou, Y.-H., & Lin, W.-T. (2005) · Environmental Pollution · doi:10.1016/j.envpol.2004.11.005 · Cited by 50
Hofmann, W., Morawska, L., & Bergmann, R. (2001) · Journal of Aerosol Medicine · doi:10.1089/089426801316970277 · Cited by 45
Sturm, R. (2006) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2006.06.004 · Cited by 42
Pegaz, B., Debefve, E., Ballini, J., et al. (2006) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2006.07.008 · Cited by 37
In vitro evaluation of nanoparticles spleen capture
Demoy, M., Andreux, J. P., Weingarten, C., Gouritin, B., Guilloux, V., & Couvreur, P. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00068-5 · Cited by 35
Evans, M. V., Dowd, S. M., Kenyon, E. M., Hughes, M. F., & El-Masri, H. A. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn080 · Cited by 32
Portet, D., Denizot, B., Rump, E., Hindré, F., Jeune, J. L., & JALLET, P. (2001) · Drug Development Research · doi:10.1002/ddr.10027 · Cited by 27
Peters, S. A., Ungell, A.-L. B., & Dolgos, H. (2009) · PubMed · Cited by 25
Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment
Knaak, J. B., Dary, C. C., Okino, M. S., Power, F. W., Zhang, X., Thompson, C. B., Tornero‐Velez, R., & Blancato, J. N. (2008) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-0-387-73163-6_3 · Cited by 21
Davies, C. P., & Webster, A. J. (1987) · PubMed Central · Cited by 8
Cited by
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Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321
Hoang Thi, T. T., Pilkington, E. H., Nguyen, D. H., Lee, J. S., Park, K. D., & Truong, N. P. (2020) · Polymers · doi:10.3390/polym12020298 · Cited by 668
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Banik, B. L., Fattahi, P., & Brown, J. L. (2016) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1364 · Cited by 485
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Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024374 · Cited by 403
Metadata
- Authors
- Li, M., Al-Jamal, K. T., Kostarelos, K., & Reineke, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-14
- Volume
- 4
- Issue
- 11
- Pages
- 6303-6317
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2031560835
- Cited by
- 351
- References
- 120
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
