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Mussel-Inspired Polydopamine: A Biocompatible and Ultrastable Coating for Nanoparticles in Vivo
Abstract
Bioinspired polydopamine (PDA) has served as a universal coating to nanoparticles (NPs) for various biomedical applications. However, one remaining critical question is whether the PDA shell on NPs is stable in vivo. In this study, we modified gold nanoparticles (GNPs) with finely controlled PDA nanolayers to form uniform core/shell nanostructures (GNP@PDA). In vitro study showed that the PDA-coated GNPs had low cytotoxicity and could smoothly translocate to cancer cells. Transmission electron microscopy (TEM) analysis demonstrated that the PDA nanoshells were intact within cells after 24 h incubation. Notably, we found the GNP@PDA could partially escape from the endosomes/lysosomes to cytosol and locate close to the nucleus. Furthermore, we observed that the PDA-coated NPs have very different uptake behavior in two important organs of the liver and spleen: GNP@PDA in the liver were mainly uptaken by the Kupffer cells, while the GNP@PDA in the spleen were uptaken by a variety of cells. Importantly, we proved the PDA nanoshells were stable within cells of the liver and spleen for at least six weeks, and GNP@PDA did not show notable histological toxicity to main organs of mice in a long time. These results provided the direct evidence to support that the PDA surface modification can serve as an effective strategy to form ultrastable coatings on NPs in vivo, which can improve the intracellular delivery capacity and biocompatibility of NPs for biomedical application.
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Citations
Cites
Daniel, M.-C., & Astruc, D. (2004) · Chemical Reviews · doi:10.1021/cr030698+ · Cited by 12,446
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Gold Nanoparticles in Chemical and Biological Sensing
Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,620
Ghosh Chaudhuri, R., & Paria, S. (2012) · Chemical Reviews · doi:10.1021/cr100449n · Cited by 3,614
The golden age: gold nanoparticles for biomedicine
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El-Sayed, M. A. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15237h · Cited by 3,550
Preparation and Characterization of Au Colloid Monolayers
Grabar, K. C., Freeman, R. G., Hommer, M. B., & Natan, M. J. (1995) · Analytical Chemistry · doi:10.1021/ac00100a008 · Cited by 2,756
Effect of Surface Properties on Nanoparticle–Cell Interactions
Verma, A., & Stellacci, F. (2010) · Small · doi:10.1002/smll.200901158 · Cited by 2,619
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,356
Liu, Y., Ai, K., Liu, J., Deng, M., He, Y., & Lu, L. (2013) · Advanced Materials · doi:10.1002/adma.201204683 · Cited by 2,019
Biological applications of gold nanoparticles
Sperling, R. A., Rivera Gil, P., Zhang, F., Zanella, M., & Parak, W. J. (2008) · Chemical Society Reviews · doi:10.1039/b712170a · Cited by 1,799
Pharmacokinetics and Biodistribution of Nanoparticles
Li, S.-D., & Huang, L. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800049w · Cited by 1,568
Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
Lee, H., Rho, J., & Messersmith, P. B. (2009) · Advanced Materials · doi:10.1002/adma.200801222 · Cited by 1,495
Bioinspired catecholic chemistry for surface modification
Ye, Q., Zhou, F., & Liu, W. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15026j · Cited by 1,177
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
Zhao, F., Zhao, Y., Liu, Y., Chang, X., Chen, C., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201100001 · Cited by 1,175
Lesniak, A., Fenaroli, F., Monopoli, M. P., Åberg, C., Dawson, K. A., & Salvati, A. (2012) · ACS Nano · doi:10.1021/nn300223w · Cited by 1,020
Current status of polymeric gene delivery systems☆
PARK, T., JEONG, J., & KIM, S. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.007 · Cited by 944
Polydopamine—a nature-inspired polymer coating for biomedical science
Lynge, M. E., van der Westen, R., Postma, A., & Städler, B. (2011) · Nanoscale · doi:10.1039/c1nr10969c · Cited by 907
Nanomaterials: Applications in Cancer Imaging and Therapy
Barreto, J. A., O’Malley, W., Kubeil, M., Graham, B., Stephan, H., & Spiccia, L. (2011) · Advanced Materials · doi:10.1002/adma.201100140 · Cited by 907
Ju, K.-Y., Lee, Y., Lee, S., Park, S. B., & Lee, J.-K. (2011) · Biomacromolecules · doi:10.1021/bm101281b · Cited by 806
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A., & Zhao, Y. (2013) · Accounts of Chemical Research · doi:10.1021/ar300031y · Cited by 803
Jiang, J., Zhu, L., Zhu, L., Zhu, B., & Xu, Y. (2011) · Langmuir · doi:10.1021/la202877k · Cited by 750
The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
Cho, E. C., Zhang, Q., & Xia, Y. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.58 · Cited by 719
Xi, Z.-Y., Xu, Y.-Y., Zhu, L.-P., Wang, Y., & Zhu, B.-K. (2009) · Journal of Membrane Science · doi:10.1016/j.memsci.2008.11.037 · Cited by 697
Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles
Nativo, P., Prior, I. A., & Brust, M. (2008) · ACS Nano · doi:10.1021/nn800330a · Cited by 659
Catechols as versatile platforms in polymer chemistry
Faure, E., Falentin-Daudré, C., Jérôme, C., Lyskawa, J., Fournier, D., Woisel, P., & Detrembleur, C. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.06.004 · Cited by 616
Della Vecchia, N. F., Avolio, R., Alfè, M., Errico, M. E., Napolitano, A., & d'Ischia, M. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201202127 · Cited by 582
Asanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 516
Self-Polymerization of Dopamine as a Versatile and Robust Technique to Prepare Polymer Capsules
Postma, A., Yan, Y., Wang, Y., Zelikin, A. N., Tjipto, E., & Caruso, F. (2009) · Chemistry of Materials · doi:10.1021/cm901293e · Cited by 494
Biocompatible polydopamine fluorescent organic nanoparticles: facile preparation and cell imaging
Zhang, X., Wang, S., Xu, L., Feng, L., Ji, Y., Tao, L., Li, S., & Wei, Y. (2012) · Nanoscale · doi:10.1039/c2nr31281f · Cited by 488
Coating carbon nanotubes by spontaneous oxidative polymerization of dopamine
Fei, B., Qian, B., Yang, Z., Wang, R., Liu, W. C., Mak, C. L., & Xin, J. H. (2008) · Carbon · doi:10.1016/j.carbon.2008.06.049 · Cited by 468
One‐Step Modification of Superhydrophobic Surfaces by a Mussel‐Inspired Polymer Coating
Kang, S. M., You, I., Cho, W. K., Shon, H. K., Lee, T. G., Choi, I. S., Karp, J. M., & Lee, H. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201004693 · Cited by 442
Simultaneous Reduction and Surface Functionalization of Graphene Oxide by Mussel‐Inspired Chemistry
Kang, S. M., Park, S., Kim, D., Park, S. Y., Ruoff, R. S., & Lee, H. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201001692 · Cited by 439
Mussel-Inspired Encapsulation and Functionalization of Individual Yeast Cells
Yang, S. H., Kang, S. M., Lee, K.-B., Chung, T. D., Lee, H., & Choi, I. S. (2011) · Journal of the American Chemical Society · doi:10.1021/ja1100189 · Cited by 432
Combination of Bioinspiration: A General Route to Superhydrophobic Particles
Zhang, L., Wu, J., Wang, Y., Long, Y., Zhao, N., & Xu, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303037j · Cited by 404
Silica-Coating and Hydrophobation of CTAB-Stabilized Gold Nanorods
Pastoriza-Santos, I., Pérez-Juste, J., & Liz-Marzán, L. M. (2006) · Chemistry of Materials · doi:10.1021/cm060293g · Cited by 395
Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering
Bettinger, C. J., Bruggeman, J. P., Misra, A., Borenstein, J. T., & Langer, R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.018 · Cited by 381
Liu, X., Chen, Y., Li, H., Huang, N., Jin, Q., Ren, K., & Ji, J. (2013) · ACS Nano · doi:10.1021/nn402201w · Cited by 356
Self-citationPolydopamine Spheres as Active Templates for Convenient Synthesis of Various Nanostructures
Yan, J., Yang, L., Lin, M., Ma, J., Lu, X., & Lee, P. S. (2013) · Small · doi:10.1002/smll.201201064 · Cited by 355
Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier
Qiao, R., Jia, Q., Hüwel, S., Xia, R., Liu, T., Gao, F., Galla, H.-J., & Gao, M. (2012) · ACS Nano · doi:10.1021/nn300240p · Cited by 326
Cui, J., Yan, Y., Such, G. K., Liang, K., Ochs, C. J., Postma, A., & Caruso, F. (2012) · Biomacromolecules · doi:10.1021/bm300835r · Cited by 317
Attenuation of The In Vivo Toxicity of Biomaterials by Polydopamine Surface Modification
Hong, S., Kim, K. Y., Wook, H. J., Park, S. Y., Lee, K. D., Lee, D. Y., & Lee, H. (2011) · Nanomedicine · doi:10.2217/nnm.11.76 · Cited by 309
Zhang, M., Zhang, X., He, X., Chen, L., & Zhang, Y. (2012) · Nanoscale · doi:10.1039/c2nr30316g · Cited by 302
Polymer‐Coated Nanoparticles: A Universal Tool for Biolabelling Experiments
Zhang, F., Lees, E., Amin, F., Rivera_Gil, P., Yang, F., Mulvaney, P., & Parak, W. J. (2011) · Small · doi:10.1002/smll.201100608 · Cited by 297
Cui, J., Wang, Y., Postma, A., Hao, J., Hosta‐Rigau, L., & Caruso, F. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000209 · Cited by 290
Zhou, W.-H., Lu, C.-H., Guo, X.-C., Chen, F.-R., Yang, H.-H., & Wang, X.-R. (2010) · J. Mater. Chem. · doi:10.1039/b916619j · Cited by 273
Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings
Pidhatika, B., Rodenstein, M., Chen, Y., Rakhmatullina, E., Mühlebach, A., Acikgöz, C., Textor, M., & Konradi, R. (2012) · Biointerphases · doi:10.1007/s13758-011-0001-y · Cited by 251
The State of Nanoparticle-Based Nanoscience and Biotechnology: Progress, Promises, and Challenges
Pelaz, B., Jaber, S., de Aberasturi, D. J., Wulf, V., Aida, T., de la Fuente, J. M., Feldmann, J., Gaub, H. E., Josephson, L., Kagan, C. R., et al. (2012) · ACS Nano · doi:10.1021/nn303929a · Cited by 233
Black, K. C., Yi, J., Rivera, J. G., Zelasko-Leon, D. C., & Messersmith, P. B. (2013) · Nanomedicine · doi:10.2217/nnm.12.82 · Cited by 230
Robust polydopamine nano/microcapsules and their loading and release behavior
Yu, B., Wang, D. A., Ye, Q., Zhou, F., & Liu, W. (2009) · Chemical Communications · doi:10.1039/b910679k · Cited by 221
Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering
Tsai, W.-B., Chen, W.-T., Chien, H.-W., Kuo, W.-H., & Wang, M.-J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.07.024 · Cited by 220
Liu, X., Huang, N., Li, H., Jin, Q., & Ji, J. (2013) · Langmuir · doi:10.1021/la401556k · Cited by 209
Self-citationNa, H. B., Palui, G., Rosenberg, J. T., Ji, X., Grant, S. C., & Mattoussi, H. (2012) · ACS Nano · doi:10.1021/nn203735b · Cited by 192
Schrand, A. M., Schlager, J. J., Dai, L., & Hussain, S. M. (2010) · Nature Protocols · doi:10.1038/nprot.2010.2 · Cited by 167
Kim, J., Kim, H. S., Lee, N., Kim, T., Kim, H., Yu, T., Song, I. C., Moon, W. K., & Hyeon, T. (2008) · Angewandte Chemie · doi:10.1002/ange.200802469 · Cited by 167
Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies
Klippstein, R., & Pozo, D. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.01.001 · Cited by 159
Lin, A. Y., Almeida, J. P. M., Bear, A. S., Liu, N., Luo, L., Foster, A. E., & Drezek, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063550 · Cited by 155
Zhang, M., He, X., Chen, L., & Zhang, Y. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm01336f · Cited by 142
Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R., & Bischof, J. C. (2012) · Molecular Pharmaceutics · doi:10.1021/mp200626j · Cited by 139
Dopamine-Mediated Continuous Assembly of Biodegradable Capsules
Ochs, C. J., Hong, T., Such, G. K., Cui, J., Postma, A., & Caruso, F. (2011) · Chemistry of Materials · doi:10.1021/cm201390e · Cited by 129
Wu, C., Fan, W., Chang, J., & Xiao, Y. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm12770e · Cited by 109
Si, J., & Yang, H. (2011) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2011.03.039 · Cited by 109
Strategies in biomimetic surface engineering of nanoparticles for biomedical applications
Gong, Y., & Winnik, F. M. (2011) · Nanoscale · doi:10.1039/c1nr11297j · Cited by 107
Quarta, A., Curcio, A., Kakwere, H., & Pellegrino, T. (2012) · Nanoscale · doi:10.1039/c2nr30271c · Cited by 97
Polydopamine/Liposome Coatings and Their Interaction with Myoblast Cells
Lynge, M. E., Ogaki, R., Laursen, A. O., Lovmand, J., Sutherland, D. S., & Städler, B. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am200358p · Cited by 91
The in vitro biomineralization and cytocompatibility of polydopamine coated carbon nanotubes
Yan, P., Wang, J., Wang, L., Liu, B., Lei, Z., & Yang, S. (2011) · Applied Surface Science · doi:10.1016/j.apsusc.2010.12.111 · Cited by 76
Faure, E., Falentin‐Daudre, C., Svaldo-Lanero, T., Vreuls, C., Zocchi, G., de Weerdt, C. V., MARTIAL, J. A., Jérôme, C., Duwez, A., & Detrembleur, C. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201106 · Cited by 71
New versatile polydopamine coated functionalized magnetic nanoparticles
Mrówczyński, R., Turcu, R., Leostean, C., Scheidt, H. A., & Liebscher, J. (2013) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2012.11.059 · Cited by 62
Dopamine-induced apoptosis in human melanocytes involves generation of reactive oxygen species
Chu, C., Liu, Y., Chiu, H., & Jee, S. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07293.x · Cited by 51
Myoblast Cell Interaction with Polydopamine Coated Liposomes
van der Westen, R., Hosta‐Rigau, L., Sutherland, D. S., Goldie, K. N., Alberício, F., Postma, A., & Städler, B. (2012) · Biointerphases · doi:10.1007/s13758-011-0008-4 · Cited by 47
Hosta‐Rigau, L., Jensen, B. E. B., Fjeldsø, K. S., Postma, A., Li, G., Goldie, K. N., Alberício, F., Zelikin, A. N., & Städler, B. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200092 · Cited by 38
Mangindaan, D. W., Yared, I., Kurniawan, H., Sheu, J., & Wang, M. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34251 · Cited by 30
A green and bio-inspired process to afford durable anti-biofilm properties to stainless steel
Faure, E., Vreuls, C., Falentin‐Daudre, C., Zocchi, G., de Weerdt, C. V., MARTIAL, J. A., Jérôme, C., Duwez, A., & Detrembleur, C. (2012) · Biofouling · doi:10.1080/08927014.2012.704366 · Cited by 21
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Metadata
- Authors
- Liu, X., Cao, J., Li, H., Li, J., Jin, Q., Ren, K., & Ji, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-09-11
- Volume
- 7
- Issue
- 10
- Pages
- 9384-9395
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2328886593
- Cited by
- 667
- References
- 72
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- closed
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