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Cited by 709

The DOI matches its Crossref record; 186 of the 186 references it cites were found in a registry or an index.

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

Open access
Nguyen, Linh P., Bradfield, Christopher A.·2008·Chemical Research in Toxicology

Abstract

The primary design of this perspective is to describe the major ligand classes of the aryl hydrocarbon receptor (AHR). A grander objective is to provide models that may help define the physiological activator or "endogenous ligand" of the AHR. We present evidence supporting a developmental role for the AHR and propose mechanisms by which an endogenous ligand and consequent AHR activation might be important during normal physiology and development. From this vista, we survey the known xenobiotic, endogenous, dietary, and "unconventional" activators of the AHR, including, when possible, information about their induction potency, receptor binding affinity, and potential for exposure. In light of the essential function of the AHR in embryonic development, we discuss the candidacy of each of these compounds as physiologically important activators.

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Crossref · 10.1021/tx7001965

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Metadata

Authors
Nguyen, L. P., & Bradfield, C. A.
Venue
Chemical Research in Toxicology
Published
2007-12-13
Volume
21
Issue
1
Pages
102-116
ISSN
  • 0893-228X (ISSN-L)
  • 1520-5010
OpenAlex
W2107312924
Cited by
709
References
186
FWCI
24.15
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.