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Role of reactive oxygen species (ROS) in apoptosis induction
Abstract
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
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High levels of mitochondrial ROS can initiate intrinsic apoptosis leading to the release of cytochrome c into the cytosol from the mitochondrial intermembrane space.
“High levels of mitochondrial ROS can initiate intrinsic apoptosis leading to the release of cytochrome c into the cytosol from the mitochondrial intermembrane space.45”
From Reactive Oxygen Species in Cancer: Current Findings and Future Directions (2021) · cites this paper as [45]
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Metadata
- Authors
- Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F.
- Affiliations
- University of Bern (CH)
- Hebrew University of Jerusalem (IL)
- ORCID
- Simon, H.-U.
- Venue
- Apoptosis
- Published
- 2000-11
- Volume
- 5
- Issue
- 5
- Pages
- 415-418
- ISSN
- 1360-8185 (ISSN-L)
- 1573-675X
- OpenAlex
- W2148125367
- Cited by
- 2,774
- References
- 50
- Citations by year
- 2026: 59 · 2025: 91 · 2024: 116 · 2023: 150 · 2022: 173 · 2021: 179 · 2020: 201 · 2019: 160 · 2018: 214 · 2017: 182 · 2016: 188 · 2015: 173 · 2014: 148 · 2013: 133 · 2012: 121
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- APOPTOSIS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Helmut Horten Stiftung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- reactive oxygen species, mitochondria, cytochrome c release, caspase activation, anti-apoptotic effects, inflammatory cells, redox signaling
- MeSH terms
- Animals, Humans, Apoptosis, Reactive Oxygen Species
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