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Cited by 88Posttraumatic Stress Disorder ResearchMigration, Health and TraumaChild Abuse and Trauma

The DOI matches its Crossref record.

Co‐twin control study of relationships among combat exposure, combat‐related PTSD, and other mental disorders

Koenen, Karestan C., Lyons, Michael J., Goldberg, Jack, Simpson, John, Williams, Wesley M., Toomey, Rosemary, Eisen, Seth A., True, William, Tsuang, Ming T.·2003·Journal of Traumatic Stress
DOI 10.1023/a:1025786925483
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Abstract

The well-documented association between combat-related PTSD (C-PTSD) and other mental disorders may be an artifact of shared familial vulnerability. This study uses a co-twin control design to examine whether the association between C-PTSD and other mental disorders persists after adjusting for shared familial vulnerability. Data were from male monozygotic twin pairs in the Vietnam Era Twin Registry. Logistic regression analyses demonstrated that combat exposure, adjusted for C-PTSD, was significantly associated with increased risk for alcohol and cannabis dependence and that C-PTSD mediated the association between combat exposure and both major depression and tobacco dependence. We conclude C-PTSD comorbidity persists after controlling for shared vulnerability. Combat exposure is directly and indirectly, through C-PTSD, associated with increased risk for other mental disorders.

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  • The current study's null findings for other traumatic SLEs are not in accordance with previous genetically informative studies that found increased depression risk associated with combat exposure and somatic illness/injury.

    “This is not in accordance with results from previous genetically informative studies, which have found increased depression risk associated with combat exposure (Koenen et al., 2003) and somatic illness and injury (Kendler et al., 1999a).”

    From Stressful life events increase the risk of major depressive episodes: A population-based twin study (2023) · cites this paper as Koenen et al., 2003

  • Previous genetically informative studies have found increased depression risk associated with combat exposure and somatic illness/injury.

    “previous genetically informative studies, which have found increased depression risk associated with combat exposure (Koenen et al., 2003) and somatic illness and injury (Kendler et al., 1999a).”

    From Stressful life events increase the risk of major depressive episodes: A population-based twin study (2023) · cites this paper as Koenen et al., 2003

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Research works printed but not linked: 19

  1. American Psychiatric Association, 1987, Diagnostic and statistical manual of mental disorders
  2. 10.1080/02791072.1999.10471731 · DOI
  3. 10.1016/S0006-3223(00)00933-1 · DOI · Paper page
  4. Breslow N. E., 1980, Statistical methods in cancer research, 1. The analysis of case‐control studies
  5. 10.1001/archpsyc.55.10.913 · DOI
  6. Cohen J., 1977, Statistical power analysis for the behavioral sciences (Rev.)
  7. 10.1111/j.1399-0004.1989.tb02967.x · DOI
  8. 10.1017/S0001566000004591 · DOI
  9. Henderson W. T., 1990, Vietnam era twin registry: A resource for medical research, Public Health Report, 105, 368
  10. 10.1002/1097-4679(199101)47:1<80::AID-JCLP2270470112>3.0.CO;2-9 · DOI
  11. 10.1111/j.1559-1816.1990.tb01511.x · DOI
  12. 10.1001/archpsyc.57.10.953 · DOI · Paper page
  13. 10.1001/archpsyc.1995.03950240066012 · DOI · Paper page
  14. 10.1097/00005053-200204000-00001 · DOI
  15. Kulka R. A., 1990, Trauma and the Vietnam War generation: Report of the findings from the national Vietnam veterans readjustment study
  16. 10.1176/ajp.149.11.1568 · DOI
  17. Robins L. N., 1988, National Institute of Mental Health Diagnostic Interview Schedule Version III—revised
  18. Rothman K. J., 2002, Epidemiology: An introduction
  19. 10.1016/S0376-8716(00)00127-7 · DOI

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Metadata

Authors
Koenen, K. C., Lyons, M. J., Goldberg, J., Simpson, J., Williams, W. M., Toomey, R., Eisen, S. A., True, W., & Tsuang, M. T.
Affiliations
  • Boston University (US)
  • University of Washington (US)
  • Harvard University (US)
  • Washington University in St. Louis (US)
  • St. Louis VA Medical Center (US)
Corresponding author
Koenen, Karestan C.
ORCID
Venue
Journal of Traumatic Stress
Publisher
Wiley
Published
2003-10
Volume
16
Issue
5
Pages
433-438
ISSN
  • 0894-9867 (ISSN-L)
  • 1573-6598
DOI
10.1023/a:1025786925483
OpenAlex
W2100365790
Cited by
88
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 2
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 638 d)
Locations
  • Journal of Traumatic Stress (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01aa010339-03)
  • Centers for Disease Control and Prevention
  • National Institute on Alcohol Abuse and Alcoholism (R01AA010586, AA-10339, AA10586)
  • National Institute of Mental Health (MH11954-01, F31MH011954)
  • National Institute on Drug Abuse (R01DA004604, DA-04604)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
combat-related PTSD, combat exposure, alcoholism, cannabis use disorder, major depressive disorder, tobacco dependence, Vietnam Era Twin Registry, monozygotic twins, mediation
MeSH terms
Adult, Alcohol Drinking, Mental Disorders, Marijuana Abuse, Humans, Male, Middle Aged, Military Personnel, Risk Factors, Stress Disorders, Post-Traumatic, Warfare, Comorbidity, Odds Ratio

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