The DOI matches its Crossref record; 172 of the 175 references it cites were found in a registry or an index.
The Emotional Brain, Fear, and the Amygdala
Open accessAbstract
1. Considerable progress has been made over the past 20 years in relating specific circuits of the brain to emotional functions. Much of this work has involved studies of Pavlovian or classical fear conditioning, a behavioral procedure that is used to couple meaningless environmental stimuli to emotional (defense) response networks. 2. The major conclusion from studies of fear conditioning is that the amygdala plays critical role in linking external stimuli to defense responses. 3. Before describing research on the role of the amygdala in fear conditioning, though, it will be helpful to briefly examine the historical events that preceded modern research on conditioned fear.
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In the citing paper
“Briefly, the association between a stimulus predicting shock and the shock forms in basolateral regions of the amygdala.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as LeDoux, 2003
In the citing paper
“From there the information passes to the central nucleus of the amygdala, which in turns projects to the regions that control the behaviors and physiological responses that are the symptoms of fear (Davis, Rainnie, & Cassell, 1994; LeDoux, 2003; Maren & Quirk, 2004).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as LeDoux, 2003
In the citing paper
“The anatomical projections from the amygdala and mPFC to the hypothalamus, PAG, locus ceruleus, raphe, and autonomic-related brainstem nuclei play major roles in organizing the endocrine, autonomic, and behavioral responses to stressors and emotional stimuli (Figure 10) (Davis and Shi, 1999;LeDoux, 2003;O ¨ngu ¨r et al, 2003).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as LeDoux, 2003
In the citing paper
“Parallel and convergent efferent projections from the amygdala and the medial prefrontal network to the hypothalamus, periaqueductal gray (PAG), nucleus basalis, locus ceruleus, dorsal raphe, and medullary vagal nuclei organize neuroendocrine, autonomic, neurotransmitter and behavioral responses to stressors and emotional stimuli”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as LeDoux, 2003
In the citing paper
“Amygdala stimulation of the locus ceruleus, lateral hypothalamus and PAG increases sympathetic autonomic arousal in rodents (Fig. 5) (LeDoux 2003; Gold and Chrousos 2002).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as LeDoux 2003
In the citing paper
“The BLA sends anatomical projections to the central nucleus of the amygdala (ACe) and the BNST, and projections from these structures to the hypothalamus, PAG, nucleus basalis, locus ceruleus, raphe and other diencencephalic and brainstem nuclei play major roles in organizing the neuroendocrine, neurotransmitter, autonomic, and behavioral responses to stressors and emotional stimuli (Davis and Shi”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as LeDoux 2003
In the citing paper
“positive memories are rarely induced in mice, unlike fear conditioning, which is more commonly used for its robustness and long-lasting effects [45–47].”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [46]
In the citing paper
“The expression and inhibition of learned fear is largely regulated by the amygdala, hippocampus, and PFC in adult rodents and humans (Knapska et al., 2012;LeDoux, 2003;Maren and Quirk, 2004;Tovote et al., 2015)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as LeDoux, 2003
In the citing paper
“required for the acquisition and expression of learned fear”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as LeDoux, 2003
In the citing paper
“Fear is a defensive mechanism that activates behavioral and neurobiological responses to danger that promote survival, including freezing and activation of sympathetic nervous system and HPA axis”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as LeDoux, 2003
In the citing paper
“An extensive literature in rodents has characterized the neural circuitry that underlies fear learning using Pavlovian fear conditioning tasks”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as LeDoux, 2003
In the citing paper
“The CMA is critical in the generation of behavioral responses through projections to the brainstem, striatum, and regions of the cortex (LeDoux, 2003).”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as LeDoux, 2003
In the citing paper
“The amygdala can be subdivided into basolateral (BLA), centromedial (CMA) and superficial (SFA) nuclei, each with distinct functional connections to the cortex supporting different brain functions.”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as LeDoux, 2003
In the citing paper
“The BLA facilitates associative learning processes, like fear conditioning, through afferent projections from the frontal cortex and other subcortical regions (LeDoux, 2003, Phelps and LeDoux, 2005).”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as LeDoux, 2003
In the citing paper
“Converging evidence from this field suggests the amygdalaa key brain region for emotion regulation (LeDoux, 2003), processing (Seeley et al., 2007), detection (Ousdal et al., 2008), and vigilance for social cues across sensory modalities (Whalen, 2007) is an important target of OT administration.”
In the citing paper
“decreasing amygdala cholinergic activity through α4β2* nAChR blockade could decrease stress reactivity and depression-like symptoms (LeDoux, 2003; Mineur et al., 2007)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as LeDoux, 2003
In the citing paper
“The quality of parent-child relationships affects both sexual behavior and neural development and activation, specifically in the amygdala”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as LeDoux, 2003
In the citing paper
“which has been associated with reward processing (Ernst et al., 2005), emotional processing (Whalen et al., 2013), and fear response (LeDoux, 2003)”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as LeDoux, 2003
Citations
Cites
(1999) · Cited by 12,812
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Self-citationDESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
(1995) · Medical Entomology and Zoology · Cited by 7,217
Working with Emotional Intelligence
Goleman, D. (1999) · ETC: A Review of General Semantics · doi:10.66774/etc_5601_103 · Cited by 6,254
(1962) · Medical Entomology and Zoology · Cited by 4,856
Cited by
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Items 601–700 of 1,004
Campbell, M. (2008) · Heart & Lung · doi:10.1016/j.hrtlng.2007.05.007 · Cited by 40
Brzozowska, A., & Grabowski, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115216 · Cited by 39
Impaired visuocortical discrimination learning of socially conditioned stimuli in social anxiety
Ahrens, L. M., Mühlberger, A., Pauli, P., & Wieser, M. J. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu140 · Cited by 39
Associative learning and the genetics of schizophrenia
Hall, J., Romaniuk, L., McIntosh, A. M., Steele, J. D., Johnstone, E. C., & Lawrie, S. M. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.011 · Cited by 39
Kim, S., Lee, M.-J., Chung, Y., & Bong, M. (2010) · Contemporary Educational Psychology · doi:10.1016/j.cedpsych.2010.04.002 · Cited by 39
Central Role of the Brain in Stress and Adaptation
McEwen, B. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800951-2.00005-4 · Cited by 39
Neuronal histamine and the memory of emotionally salient events
Provensi, G., Passani, M. B., Costa, A., Izquierdo, I., & Blandina, P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14476 · Cited by 39
Brehl, A.-K., Kohn, N., Schene, A. H., & Fernández, G. (2020) · Psychological Medicine · doi:10.1017/s0033291720000410 · Cited by 39
Hyperacusis: Loudness intolerance, fear, annoyance and pain
Salvi, R., Chen, G., & Manohar, S. (2022) · Hearing Research · doi:10.1016/j.heares.2022.108648 · Cited by 39
Neural Correlates of Emotional Interference in Social Anxiety Disorder
Boehme, S., Ritter, V., Tefikow, S., Stangier, U., Strauss, B. M., Miltner, W. H. R., & Straube, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128608 · Cited by 39
Enhanced long term microcircuit plasticity in the valproic acid animal model of autism
Testa-Silva, G. (2009) · Frontiers in Synaptic Neuroscience · doi:10.3389/neuro.19.001.2009 · Cited by 39
Distracted by danger: Temporal and spatial dynamics of visual selection in the presence of threat
Mulckhuyse, M., & Dalmaijer, E. S. (2016) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-015-0391-2 · Cited by 38
Robust hippocampal responsivity during retrieval of consolidated associative memory
Hattori, S., Chen, L., Weiss, C., & Disterhoft, J. F. (2014) · Hippocampus · doi:10.1002/hipo.22401 · Cited by 38
The dynamic influence of emotional words on sentence comprehension: An ERP study
Ding, J., Wang, L., & Yang, Y. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0403-x · Cited by 38
Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance
Fortenbaugh, F. C., Corbo, V., Poole, V. N., McGlinchey, R. E., Milberg, W., Salat, D. H., Degutis, J. M., & Esterman, M. S. (2017) · Brain and Behavior · doi:10.1002/brb3.684 · Cited by 38
Callaghan, B. L., Dandash, O., Simmons, J. G., Schwartz, O., Byrne, M. L., Sheeber, L., Allen, N. B., & Whittle, S. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.09.415 · Cited by 38
Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B. J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816247116 · Cited by 38
The Genetic Basis of Emotional Behavior: Has the Time Come for a Drosophila Model?
Iliadi, K. G. (2009) · Journal of Neurogenetics · doi:10.1080/01677060802471650 · Cited by 38
Taylor, S. B., Taylor, A. R., & Koenig, J. I. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.045 · Cited by 38
Neurobiology of the metabolic syndrome: An allostatic perspective
van Dijk, G., & Buwalda, B. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.079 · Cited by 38
A recurrent network in the lateral amygdala: a mechanism for coincidence detection
Johnson, L. R. (2008) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.003.2008 · Cited by 38
Roosters do not warn the bird in the mirror: The cognitive ecology of mirror self-recognition
Hillemacher, S., Ocklenburg, S., Güntürkün, O., & Tiemann, I. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291416 · Cited by 37
Lesting, J., Geiger, M., Narayanan, R. T., Pape, H., & Seidenbecher, T. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02758.x · Cited by 37
Neural responses to emotional faces in women recovered from anorexia nervosa
Cowdrey, F. A., Harmer, C. J., Park, R. J., & McCabe, C. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.08.009 · Cited by 37
Arnold, M. M., Loughlin, S. E., Belluzzi, J. D., & Leslie, F. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.035 · Cited by 37
A comparison of structural connectivity in anxious depression versus non-anxious depression
Delaparte, L., Yeh, F.-C. F., Adams, P., Malchow, A. L., Trivedi, M. H., Oquendo, M. A., Deckersbach, T., Ogden, R. T., Pizzagalli, D. A., D, M. F. M., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.01.012 · Cited by 37
Multidimensional Neural Selectivity in the Primate Amygdala
Putnam, P. T., & Gothard, K. M. (2019) · eNeuro · doi:10.1523/eneuro.0153-19.2019 · Cited by 37
Challenges in researching the immune pathways between early life adversity and psychopathology
Reid, B. M., & Danese, A. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001157 · Cited by 37
Afraid of the dark: Light acutely suppresses activity in the human amygdala
McGlashan, E. M., Poudel, G. R., Jamadar, S. D., Phillips, A. J. K., & Cain, S. W. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252350 · Cited by 37
Ge, L., Hu, Z., Wang, W., Parco Ming-fai, S. I. U., & Wei, G. (2021) · Life · doi:10.3390/life11060577 · Cited by 37
Genetic influences in emotional dysfunction and alcoholism-related brain damage
Oscar‐Berman, M., & Bowirrat, A. (2005) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a788 · Cited by 37
The Insular Cortex and the Amygdala: Shared Functions and Interactions
Moraga‐Amaro, R., & Stehberg, J. (2012) · InTech eBooks · doi:10.5772/48495 · Cited by 37
Olfactory functioning in panic disorder
Burón, E., Bulbena, A., & Bulbena‐Cabré, A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.049 · Cited by 37
Easy to remember, difficult to forget: The development of fear regulation
Johnson, D. C., & Casey, B. J. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.07.006 · Cited by 37
Dysfunctions within limbic–motor networks in amyotrophic lateral sclerosis
Passamonti, L., Fera, F. S., Tessitore, A., Russo, A., Cerasa, A., Gioia, C. M., Monsurrò, M. R., Migliaccio, R., Tedeschi, G., & Quattrone, A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.016 · Cited by 37
Sampedro‐Piquero, P., Castilla‐Ortega, E., Zancada-Menéndez, C., Santín, L. J., & Begega, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.032 · Cited by 37
Sonkusare, S., Ding, Q., Zhao, Y., Liu, W., Yang, R., Mandali, A., Manssuer, L. R., Zhang, C., Cao, C., Sun, B., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01883-2 · Cited by 36
Flint, A. E., Waterman, M. G., Bowmer, G., Vadlamani, G., Chumas, P., & Morrall, M. C. H. J. (2017) · Seizure · doi:10.1016/j.seizure.2017.09.011 · Cited by 36
Contextual Fear Conditioning Alter Microglia Number and Morphology in the Rat Dorsal Hippocampus
Chaaya, N., Jacques, A., Belmer, A., Beecher, K., Ali, S. A., Chehrehasa, F., Battle, A. R., Johnson, L. R., & Bartlett, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00214 · Cited by 36
Muscarinic Receptors in Amygdala Control Trace Fear Conditioning
Baysinger, A. N., Kent, B. A., & Brown, T. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045720 · Cited by 36
Factors governing single-trial contextual fear conditioning in the weanling rat.
Burman, M. A., Murawski, N. J., Schiffino, F. L., Rosen, J. B., & Stanton, M. E. (2009) · Behavioral Neuroscience · doi:10.1037/a0016733 · Cited by 36
Goode, T. D., Leong, K.-C., Goodman, J., Maren, S., & Packard, M. G. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.02.004 · Cited by 35
Emotion in motion: A three-stage model of aversive classical conditioning
Lindquist, D. H. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.025 · Cited by 35
Sherrin, T., Todorovic, C., Zeyda, T., Tan, C. H., Hon, P. W. T., Zhu, Y. Z., & Spiess, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002121 · Cited by 35
Pockros, L. A., Pentkowski, N. S., Der-Ghazarian, T. S., & Neisewander, J. L. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000856 · Cited by 35
Li, Z., & Richter‐Levin, G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00021 · Cited by 35
Implications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz, E. R., Gee, D. G., Pine, D. S., & Silverman, W. K. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.01.005 · Cited by 35
The Neuropsychology of Emotion and Emotion Regulation: The Role of Laterality and Hierarchy
Turnbull, O. H., & Salas, C. E. (2021) · Brain Sciences · doi:10.3390/brainsci11081075 · Cited by 35
Gao, Y., Sun, J., Cheng, L. L., Yang, Q., Li, J., Hao, Z., Zhan, L., Shi, Y., Li, M., Jia, X., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.011 · Cited by 35
Chen, X., Zhang, H., & Zou, Y. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.011 · Cited by 35
Altered emotional and motivational processing in the transgenic rat model for Huntington’s disease
Faure, A., Höhn, S., von Hörsten, S., Delatour, B., Raber, K. A., Leblanc-Veyrac, P., Samson-Desvignes, N., Doyère, V., & Massioui, N. E. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.11.010 · Cited by 35
Calfa, G. D., Volosin, M., & Molina, V. A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.022 · Cited by 35
Walker, J. E., Kozlowski, G. P., & Lawson, R. (2007) · Journal of Neurotherapy · doi:10.1300/j184v11n01_03 · Cited by 35
Purkis, H. M., Lester, K. J., & Field, A. P. (2011) · Emotion · doi:10.1037/a0024415 · Cited by 35
Silberman, Y., Ariwodola, O. J., & Weiner, J. L. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.196022 · Cited by 35
Comparison of Evoked vs. Spontaneous Tics in a Patient with Trigeminal Neuralgia (Tic Doloureux)
Borsook, D., Moulton, E. A., Pendse, G., Morris, S., Cole, S. H., Aiello‐Lammens, M. E., Scrivani, S. J., & Becerra, L. R. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-34 · Cited by 35
Presynaptic δ Opioid Receptors Regulate Ethanol Actions in Central Amygdala
Kang-Park, M.-H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., & Moore, S. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112722 · Cited by 35
Subirà, M., Cano, M., de Wit, S. J., Alonso, P., Cardoner, N., Hoexter, M. Q., Kwon, J. S., Nakamae, T., Löchner, C., Sato, J. R., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150012 · Cited by 34
Schmitt, A., Upadhyay, N., Martin, J. A., Vega, S. R., Strüder, H. K., & Boecker, H. (2020) · Neural Plasticity · doi:10.1155/2020/7905387 · Cited by 34
tDCS-Augmented in vivo exposure therapy for specific fears: A randomized clinical trial
Cobb, A. R., O’Connor, P., Zaizar, E. D., Caulfield, K. A., Gonzalez-Lima, F., & Telch, M. J. (2020) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2020.102344 · Cited by 34
Zhang, L., Lu, L., Bu, X., Li, H., Tang, S., Gao, Y., Liang, K., Zhang, S., Hu, X., Wang, Y., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25356 · Cited by 34
Falk, A. E., & Lee, S. S. (2011) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-011-9268-z · Cited by 34
Opposing amygdala and ventral striatum connectivity during emotion identification
Satterthwaite, T. D., Wolf, D. H., Pinkham, A. E., Ruparel, K., Elliott, M. A., Valdez, J. N., Overton, E. E., Seubert, J., Gur, R. E., Gur, R. C., et al. (2011) · Brain and Cognition · doi:10.1016/j.bandc.2011.04.005 · Cited by 34
Linhart, P., Fuchs, R., Poláková, S., & Slabbekoorn, H. (2012) · Journal of Avian Biology · doi:10.1111/j.1600-048x.2012.05580.x · Cited by 34
Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion
Mukherjee, P., Whalley, H. C., McKirdy, J. W., McIntosh, A. M., Johnstone, E. C., Lawrie, S. M., & Hall, J. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.001 · Cited by 34
Functional connectivity in the rat brain: a complex network approach
Bifone, A., Gozzi, A., & Schwarz, A. J. (2010) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2010.07.001 · Cited by 34
Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour
Zhu, X.-N., Liu, X.-D., Sun, S., Zhuang, H., Yang, J., Henkemeyer, M. J., & Xu, N. (2016) · Nature Communications · doi:10.1038/ncomms11096 · Cited by 34
Rabellino, D., Densmore, M., Frewen, P., Théberge, J., McKinnon, M. C., & Lanius, R. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163097 · Cited by 34
Laurent, V., & Westbrook, R. F. (2010) · Learning & Memory · doi:10.1101/lm.1655010 · Cited by 34
The role of the basolateral amygdala in dreaming
Blake, Y., Terburg, D., Balchin, R., van Honk, J., & Solms, M. (2019) · Cortex · doi:10.1016/j.cortex.2018.12.016 · Cited by 33
Learned uncertainty: The free energy principle in anxiety
McGovern, H. T., De Foe, A., Biddell, H., Leptourgos, P., Corlett, P., Bandara, K., & Hutchinson, B. T. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.943785 · Cited by 33
Trent, S., Abdullah, M. H., Parwana, K., Valdivieso, M. A., Hassan, Z., & Müller, C. P. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111310 · Cited by 33
Buades‐Rotger, M., Beyer, F., & Krämer, U. M. (2017) · eNeuro · doi:10.1523/eneuro.0337-16.2017 · Cited by 33
Viewing Adaptive Social Choice Through the Lens of Associative Learning
FeldmanHall, O., & Dunsmoor, J. E. (2018) · Perspectives on Psychological Science · doi:10.1177/1745691618792261 · Cited by 33
Yuan, M., Pantazatos, S. P., Zhu, H., Li, Y., Miller, J. M., Rubin‐Falcone, H., Zanderigo, F., Ren, Z., Yuan, C., Lui, S., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.238 · Cited by 33
Multiple Systems for the Motivational Control of Behavior and Associated Neural Substrates in Humans
O’Doherty, J. P. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_386 · Cited by 33
Frank, G., & Kaye, W. H. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.06.011 · Cited by 33
Haegen, M. V., & Luminet, O. (2015) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2015.1067279 · Cited by 32
Zhang, X., Asim, M., Fang, W., Monir, H. M., Wang, H., Kim, K., Feng, H., Wang, S., Gao, Q., Lai, Y., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02127-7 · Cited by 32
Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery
Prior, M., Goldberg, J., Chiruta, C., Farrokhi, C. B., Kopynets, M., Roberts, A. J., & Schubert, D. A. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.03.016 · Cited by 32
Rajbhandari, A. K., Zhu, R., Adling, C., Fanselow, M. S., & Waschek, J. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23947 · Cited by 32
Scheuer, H., Alarcón, G., Demeter, D. V., Earl, E., Fair, D. A., & Nagel, B. J. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.05.012 · Cited by 32
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Fan, Y., Bao, C., Wei, Y., Wu, J., Zhao, Y.-S., Zeng, X., Qin, W., Wu, H., & Liu, P. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00159-8 · Cited by 32
Tseng, Y., Yang, H. H., Savostyanov, A. N., Chien, V. S. C., & Liou, M. (2015) · Research in Autism · doi:10.1016/j.rasd.2015.01.003 · Cited by 33
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Mao, C., & Yang, H. J. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.08.012 · Cited by 32
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Zhang, B. (2017) · PubMed Central · doi:10.13918/j.issn.2095-8137.2017.002 · Cited by 32
Pagani, J. H., & Rosen, J. B. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.062 · Cited by 32
Daniels, W. M. U., Richter, L., & Stein, D. J. (2004) · Metabolic Brain Disease · doi:10.1023/b:mebr.0000027413.42946.61 · Cited by 32
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Pereira, N. D. S. C., Lampert, C., Vieira, A. D. S., Lazzaretti, C., Kincheski, G. C., Espejo, P. J., Molina, V. A., Quillfeldt, J. A., & Dalmaz, C. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00134 · Cited by 31
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Metadata
- Authors
- LeDoux, J.
- Affiliations
- New York University (US)
- Corresponding author
- LeDoux, Joseph
- ORCID
- LeDoux, Joseph
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2003-10
- Volume
- 23
- Issue
- 4-5
- Pages
- 727-738
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11530156
- OpenAlex
- W1513763202
- Cited by
- 1,818
- References
- 175
- Citations by year
- 2026: 60 · 2025: 85 · 2024: 80 · 2023: 73 · 2022: 73 · 2021: 119 · 2020: 88 · 2019: 125 · 2018: 83 · 2017: 87 · 2016: 114 · 2015: 95 · 2014: 77 · 2013: 85 · 2012: 96
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, fear conditioning, classical conditioning, emotional brain, defense response, emotional circuits
- MeSH terms
- Amygdala, Animals, Conditioning, Psychological, Emotions, Fear, Humans, Limbic System, Models, Neurological, Neural Pathways, Sensation, Models, Animal
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