Cited by 368Bipolar Disorder and TreatmentMental Health Research TopicsTreatment of Major Depression

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Life events and affective disorders

Paykel, E. S.·2003·Acta Psychiatrica Scandinavica

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Abstract

Objective To summarize research in life events and affective disorders Method Review of the literature. Results and conclusion Many studies have shown that episodes of unipolar depression are preceded by life events at higher rates than in control samples. A variety of stressful events are involved with only limited specificity but some relationship to social exit events. Life events also affect remission and relapse of depression. Effects of life events are less when the disorder has already been recurrent, particularly where illness is severe. Effects of life events are also weaker in bipolar disorder than unipolar, but major life events may be important in first onset. Recent evidence suggests a specific role of social rhythm disruption events in manic relapses. Causative chains are multifactorial and complex, and genetic factors can influence life event exposure.

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Authors: Paykel, E. S.
Affiliations: University of Cambridge (GB)
Corresponding author: Paykel, E. S.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2003-09-04
Volume: 108
Issue: s418
Pages: 61-66
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1034/j.1600-0447.108.s418.13.x
OpenAlex: W2106207403
Cited by: 368
References: 68
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 12 · 2019: 20 · 2018: 16 · 2017: 22 · 2016: 21 · 2015: 25 · 2014: 20 · 2013: 25 · 2012: 18
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: life events, mood disorders, major depressive disorder, bipolar disorder, depression remission, depression relapse, recurrent depression, manic relapse, genetic factors
MeSH terms: Humans, Life Change Events, Recurrence, Severity of Illness Index, Stress, Psychological, Mood Disorders, Genetic Predisposition to Disease

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