The effect of short‐term strength training on human skeletal muscle: the importance of physiologically elevated hormone levels
Abstract
The effect of strength training and endogenously elevated hormone levels (plasma testosterone, growth hormone (GH) and cortisol) was studied in 16 young untrained males, divided into an arm only training group, A, and a leg plus arm training group, LA, in order to increase circulating levels of anabolic hormones. Both groups performed the same one‐sided arm training for 9 weeks, twice a week. Group A trained only one arm (AT), the contralateral arm serving as control (AC), whereas group LA additionally trained their legs following the training of the one arm (LAT), with the contralateral arm serving as control (LAC). In spite of the attempt to match the two groups, the initial isometric arm strength was 20–25% lower for group LA compared to group A (significant for the arm to be trained). Isometric strength increased significantly in LAT and LAC by 37% and 10%, respectively, while the 9% and 2% increases in AT and AC, respectively, remained insignificant. Isokinetic strength increased at one out of three velocities tested for the trained arm relative to the untrained arm in both group A and group LA (P<0.05). Functional strength increased significantly by 20% in LAT, 18% in LAC, 19% in AT, and 17% in AC. Hormonal responses were monitored during the first and last training sessions. Resting hormone levels remained unchanged for both groups. However, during the first training session plasma testosterone as well as plasma cortisol increased significantly in group LA but not in group A. Plasma GH rose in all exercise tests, except during the last test in group LA, but was significantly higher in group LA than in group A in the first training session. In conclusion, a larger relative increase in isometric strength was found in the group having the highest hormonal response. However, due to the initial difference in isometric strength caution must be taken with the interpretation of this finding, which may only indicate a possible link between anabolic hormones and muscle strength with training.
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Proposed mechanisms of ingesting carbohydrates relate to sparing muscle glycogen and maintaining blood glucose concentrations for the duration of a match.
“The proposed mechanisms of ingesting carbohydrates relate to an effort to spare muscle glycogen and maintain blood glucose concentrations for the duration of a match 40-42 .”
From Half-time strategies to enhance second-half performance in team-sports players: A review and recommendations (2015) · cites this paper as [41]
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Hormonal Responses and Adaptations to Resistance Exercise and Training
Kraemer, W. J., & Ratamess, N. A. (2005) · Sports Medicine · doi:10.2165/00007256-200535040-00004 · Cited by 1,389 · see citing works
The mechanisms of muscle hypertrophy and their application to resistance training
Schoenfeld, B. J. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e840f3 · Cited by 1,214 · see citing works
Schoenfeld, B. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0017-1 · Cited by 495 · see citing works
“Another popular theory proposed to explain the hypertrophic mechanisms associated with metabolic stress is that a buildup of metabolites increases growth-oriented hormonal concentrations, thereby enhancing the anabolic milieu and subsequent accretion of muscle proteins [46, 65].”
BackgroundMolecular basis of skeletal muscle plasticity-from gene to form and function
Flück, M., & Hoppeler, H. H. (2003) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/s10254-002-0004-7 · Cited by 476 · see citing works
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Testosterone Physiology in Resistance Exercise and Training: The Up-Stream Regulatory Elements
Vingren, J. L., Kraemer, W. J., Ratamess, N. A., Anderson, J. M., Volek, J. S., & Maresh, C. M. (2010) · Sports Medicine · doi:10.2165/11536910-000000000-00000 · Cited by 472 · see citing works
“Similarly, exercises such as the squat([27,66,78]) and Olympic lifts,([79]) that involve a large muscle mass, produce larger elevations in testosterone compared with smaller muscle mass exercises.([76,80,81]) Larger muscle mass involvement allows for greater total volume, which helps to explain the importance of muscl…”
BackgroundKraemer, W. J., Ratamess, N. A., Hymer, W. C., Nindl, B. C., & Fragala, M. S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00033 · Cited by 323 · see citing works
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“(10, 19) are also associated with large rises in these hormones.”
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Effect of two contrasting types of physical exercise on chronic neck muscle pain
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“A transfer effect, as seen previously, of strength gains (42) and vascular adaptations in nontrained muscle groups (30) resulting from training one muscle group was not found regarding pain reduction.”
BackgroundSelf-citationCross-Transfer Effects of Resistance Training with Blood Flow Restriction
Madarame, H., Neya, M., Ochi, E., Nakazato, K., Sato, Y., & Ishii, N. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815c6d7e · Cited by 235 · see citing works
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Kvorning, T., Bagger, M., Caserotti, P., & Madsen, K. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0139-3 · Cited by 211 · see citing works
“report that hormonal responses to CRT appeared to be related to heavy loads, short rest periods and large volumes of training (Kraemer et al. 1990; Hakkinen and Pakarinen 1993; Hansen et al. 2001).”
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Blood flow restriction: The metabolite/volume threshold theory
Loenneke, J. P., Fahs, C. A., Wilson, J. M., & Bemben, M. G. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.07.029 · Cited by 190 · see citing works
“[11] suggest that evidence supporting this relationship were typically found with retrospective correlations [29–38].”
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An examination of the time course of training-induced skeletal muscle hypertrophy
DeFreitas, J. M., Beck, T. W., Stock, M. S., Dillon, M. A., & Kasishke, P. R. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1905-4 · Cited by 188 · see citing works
“unilateral training). Previous studies have shown that the total amount of muscle mass recruited and/or the total work performed aVects the systemic anabolic hormone responses that are necessary for muscle growth ( Hansen et al. 2001; Mulligan et al. 1996).”
BackgroundRecovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise
Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00599.2016 · Cited by 181 · see citing works
“In fact, some reports indicate relationships between testosterone elevation and AR upregulation and strength and hypertrophy enhancement (3, 4, 30, 82) whereas other reports indicate no such relationships (93).”
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“The hormonal response to strength training has already been studied for years (27, 11, 21, 57, 46, 36, 25, 3, 31, 33).”
BackgroundResultInfluentialSelf-citationINTERACTIONS OF CORTISOL, TESTOSTERONE, AND RESISTANCE TRAINING: INFLUENCE OF CIRCADIAN RHYTHMS
Hayes, L., Bickerstaff, G., & Baker, J. (2010) · Chronobiology International · doi:10.3109/07420521003778773 · Cited by 192 · see citing works
“However, West et al. (2010) tested strength dynamically, whereas Hansen et al. (2001b) tested strength isometrically, and this may explain at least some of the reported difference.”
BackgroundResultInfluentialWest, D. W. D., & Phillips, S. M. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2246-z · Cited by 152 · see citing works
“Changes in the systemic hormonal milieu are frequently measured since they have been suggested to influence (Beaven et al. 2008a, b; Hansen et al. 2001; Migiano et al. 2009; Ronnestad et al. 2011) and/or predict (Ahtiainen et al.”
Effect of Hydration State on Strength, Power, and Resistance Exercise Performance
Judelson, D. A., Maresh, C. M., Farrell, M. J., Yamamoto, L. M., Armstrong, L. E., Kraemer, W. J., Volek, J. S., Spiering, B. A., Casa, D. J., & Anderson, J. M. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180de5f22 · Cited by 146 · see citing works
Gharahdaghi, N., Phillips, B. E., Szewczyk, N. J., Smith, K., Wilkinson, D. J., & Atherton, P. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.621226 · Cited by 144 · see citing works
“However, this has not been confirmed (Miller et al., 2006; Sakamaki-Sunaga et al., 2016) as no differences between follicular phase and luteal phase RET responses have also been observed, at least with regard to strength gains and hypertrophy; and as such, the role of estrogen in mediating responses to RE, remains unc…”
ResultInfluentialWilkinson, S. B., Tarnopolsky, M. A., Grant, E. J. M., Correia, C. E., & Phillips, S. M. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0300-z · Cited by 135 · see citing works
“…concentration that are seen with resistance exercise are transient, normally not lasting any longer than 60–90 min after exercise (Ahtiainen et al. 2003, 2005; Hakkinen et al. 1998; Hansen et al. 2001; Kraemer et al. 1998, 2001; McCall et al. 1999; Nindl et al. 2001; Raastad et al. 2001, 2003).”
BackgroundMethodInfluentialAnabolic exercise in haemodialysis patients: a randomised controlled pilot study
Kirkman, D. L., Mullins, P. G., Junglee, N. A., Kumwenda, M. J., Jibani, M. M., & Macdonald, J. H. (2014) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-014-0140-3 · Cited by 124 · see citing works
“In fact, in those studies, the anabolic response was slightly larger (8–10 %) than observed herein, perhaps because the present study utilised only one exercise, whereas previous studies have utilised multiple lower and whole body exercises that might be expected to induce a larger systemic hypertrophic response [32].”
ResultSchoenfeld, B. J., Fisher, J. P., Grgić, J., Haun, C. T., Helms, E. R., Phillips, S. M., Steele, J., & Vigotsky, A. D. (2021) · International Journal of Strength and Conditioning · doi:10.47206/ijsc.v1i1.81 · Cited by 132 · see citing works
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“Exercise improves neurological health and decreases negative mood (Hansen et al., 2001).”
BackgroundEffects of Acute Hypoxia on Metabolic and Hormonal Responses to Resistance Exercise
Kon, M., Ikeda, T., Homma, T., Akimoto, T., SUZUKI, Y., & Kawahara, T. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181ce61a5 · Cited by 114 · see citing works
Judelson, D. A., Maresh, C. M., Yamamoto, L. M., Farrell, M. J., Armstrong, L. E., Kraemer, W. J., Volek, J. S., Spiering, B. A., Casa, D. J., & Anderson, J. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01010.2007 · Cited by 114 · see citing works
“, decreased circulating concentrations of cortisol) promote greater long-term adaptations to resistance exercise training than control exercise sessions (22, 54).”
BackgroundPhysiological elevation of endogenous hormones results in superior strength training adaptation
Rønnestad, B. R., Nygaard, H., & Raastad, T. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1860-0 · Cited by 112 · see citing works
“However, in the study by Hansen et al. (2001) legs were also trained after arm exercises and a somewhat additive effect on isometric strength, but not on isokinetic and isotonic strength was reported.”
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“In support of this finding, previous authors have observed improved upper-body strength profiles following the systemic elevation of endogenous hormones via prior lower-body resistance exercise [41].”
ResultCadore, E. L., González‐Izal, M., Pallarés, J. G., Rodríguez-Falces, J., Häkkinen, K., Kraemer, W. J., Pinto, R. S., & Izquierdo, M. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12186 · Cited by 112 · see citing works
“In addition, although mechanical tension alone can produce muscle hypertrophy, it is unlikely to be solely responsible for the hypertrophic gains associated with exercise (Hansen et al., 2001).”
BackgroundSpiering, B. A., Kraemer, W. J., Vingren, J. L., Ratamess, N. A., Anderson, J. M., Armstrong, L. E., Nindl, B. C., Volek, J. S., Häkkinen, K., & Maresh, C. M. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.02.005 · Cited by 90 · see citing works
Kristiansen, M. V., Madeleine, P., Hansen, E. A., & Samani, A. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12167 · Cited by 86 · see citing works
“…be observed between the time course of increase in strength and the increase in muscle mass. Strength will typically increase significantly in the early weeks of training (Lexell et al., 1995; Hansen et al., 2001), whereas only a very small increase can be observed in muscle mass (Phillips, 2000).”
BackgroundBeaven, C. M., Cook, C. J., & Gill, N. D. (2008) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31816357d4 · Cited by 85 · see citing works
“(14), this observation could prove beneficial for periodization prescription.”
BackgroundFrom pillow to podium: a review on understanding sleep for elite athletes
O’Donnell, S., Beaven, C. M., & Driller, M. W. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s158598 · Cited by 84 · see citing works
“36,37 It has been reported that cortisol and testosterone both follow a circadian rhythm, and are affected following sleep deprivation, with an increase in the secretion of cortisol and changes in the pattern of rhythmic secretion of testosterone, 38 which can affect the anabolic and catabolic…”
BackgroundKvorning, T., Andersen, M., Brixen, K., Schjerling, P., Suetta, C., & Madsen, K. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.122671 · Cited by 75 · see citing works
“The importance of testosterone in strength-training-induced muscle hypertrophy seems clear (Inoue et al. 1994; Hickson et al. 1994; Bhasin et al. 1996, 2001; Bamman et al. 2001; Hansen et al. 2001; Storer et al. 2003; Willoughby & Taylor, 2004; Kraemer & Ratamess, 2005).”
BackgroundSelf-citationHormonal responses to resistance exercise in long-term trained and untrained middle-aged men
Cadore, E. L., Lhullier, F. L. R., Brentano, M. A., Silva, E. M. D., Ambrosini, M. B., Spinelli, R., Silva, R. F., & Kruel, L. F. M. (2008) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31817bd45d · Cited by 73 · see citing works
“Although the concentrations of total testosterone (TT) and free testosterone (FT) are seen to increase immediately after a strength training session (1,9,20,22,33), there is some controversy regarding alterations in their concentrations at Address correspondence to Eduardo Lusa Cadore, edcadore@yahoo.”
BackgroundSchoenfeld, B. J. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828ddd53 · Cited by 74 · see citing works
“(30) 16 9* Significant increases in muscle strength as a result of acute hormonal elevations Madarame et al.”
BackgroundMethodGoto, K., Ishii, N., Kizuka, T., Kraemer, R. R., Honda, Y., & Takamatsu, K. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1075-9 · Cited by 70 · see citing works
“Relatively small changes in circulating anabolic hormones after an exercise bout can affect strength gain ( Hansen et al. 2001 )o r muscle hypertrophy (Madarame et al. 2008) following prolonged training.”
BackgroundDose Effect of Caffeine on Testosterone and Cortisol Responses to Resistance Exercise
Beaven, C. M., Hopkins, W. G., Hansen, K. T., Wood, M. R., Cronin, J. B., & Lowe, T. E. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.2.131 · Cited by 71 · see citing works
“The practical importance of acute testosterone responses to resistance training is evidenced by research showing that the magnitude of isometric strength increases are related to the magnitude of anabolic-hormone response (Hansen et al., 2001).”
BackgroundHormonal Responses to Concurrent Strength and Endurance Training with Different Exercise Orders
Cadore, E. L., Izquierdo, M., dos Santos, M. G., Martins, J. B., Lhullier, F. L. R., Pinto, R. S., Silva, R. F., & Kruel, L. F. M. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318248ab26 · Cited by 68 · see citing works
“These studies attempt to understand what factors may produce a hormonal response that favors the chronic adaptations to training, because there is some evidence to suggest that the hormonal response to individual training sessions is related to the magnitude of chronic neuromuscular adaptations to strength training (2…”
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“, 1980; Florini, 1987) and muscular strength (Dohm et al., 1980; Hanson et al., 2001).”
BackgroundEffects of Very Short Rest Periods on Hormonal Responses to Resistance Exercise in Men
Rahimi, R., Qaderi, M., Faraji, H., & Boroujerdi, S. S. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181ddb265 · Cited by 61 · see citing works
“Therefore, RE reinforces the access to muscle strength and hypertrophy (18).”
BackgroundBarroso, R., Tricoli, V., Gil, S. D. S., Ugrinowitsch, C., & Roschel, H. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31823f2b4d · Cited by 60 · see citing works
“Total volume, which affects short- and long-term responses to strength training (3,14–16,32), is positively related to myofibrillar protein synthesis (8), anabolic hormones release (14,15,36), strength gains, and skeletal muscle hypertrophy (15,16,19,29,32).”
BackgroundInfluence of exercise order on maximum strength in untrained young men
Dias, I. B. F., de Salles, B. F., Novaes, J. D. S., Costa, P. B., & Junior, R. F. S. (2009) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2008.09.003 · Cited by 58 · see citing works
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Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men
Riachy, R., McKinney, K., & Tuvdendorj, D. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5040081 · Cited by 62 · see citing works
“set of 8RM for each of the free weight squat and Smith machine squat in a randomized order with a minimum of 3 days between sessions EMG averaged over all muscles during the free weight squat was 43% higher when compared to the Smith machine squat [15]”
BackgroundMethodInfluentialKraemer, W. J., Hatfield, D. L., Spiering, B. A., Vingren, J. L., Fragala, M. S., Ho, J.-Y., Volek, J. S., Anderson, J. M., & Maresh, C. M. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0535-3 · Cited by 51 · see citing works
“Because the hormonal responses to resistance exercise potentiate adaptations with training (Hansen et al. 2001), these results indicate that chronic supplementation with MF may enhance long-term increases in muscle size and strength.”
BackgroundInfluentialEffects of Elevated Circulating Hormones on Resistance Exercise-Induced Akt Signaling
Spiering, B. A., Kraemer, W. J., Anderson, J. M., Armstrong, L. E., Nindl, B. C., Volek, J. S., Judelson, D. A., JOSEPH, M., Vingren, J. L., Hatfield, D. L., et al. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816722bd · Cited by 51 · see citing works
“Previous research clearly demonstrated that physiologically elevated circulating hormones potentiate physical adaptations after RE training (15).”
BackgroundMay, A. K., Russell, A. P., & Warmington, S. A. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3806-2 · Cited by 49 · see citing works
“2011) and isometric strength (Hansen et al. 2001) of a trained arm compared with those that underwent only arm training (i.”
BackgroundAli, K., Verma, S., Ahmad, I., Singla, D., Saleem, M. M., & Hussain, M. E. (2019) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2018.12.001 · Cited by 48 · see citing works
Kraemer, W. J., Nindl, B. C., Marx, J. O., Gotshalk, L. A., Bush, J. A., Welsch, J. R., Volek, J. S., Spiering, B. A., Maresh, C. M., Mastro, A. M., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00042.2006 · Cited by 44 · see citing works
“We included both total body and upper-body-only resistance training, because previous research (10) has shown that acute hormonal responses and subsequent strength adaptations to chronic training are greater during total body than upper-body-only resistance exercise.”
BackgroundEndocrine Response Patterns to Acute Unilateral and Bilateral Resistance Exercise in Men
Migiano, M. J., Vingren, J. L., Volek, J. S., Maresh, C. M., Fragala, M. S., Ho, J., Thomas, G. A., Hatfield, D. L., Häkkinen, K., Ahtiainen, J. P., et al. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181a92dc5 · Cited by 43 · see citing works
“A lack of a testosterone response has been shown previously for upper-body unilateral exercise (8,29), but no study has yet examined the testosterone response to bilateral upper-body resistance exercise using dumbbells.”
BackgroundInfluentialInagaki, Y., Madarame, H., Neya, M., & Ishii, N. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1899-y · Cited by 41 · see citing works
“The magnitude of exercise-induced GH secretion seems to be a complex function of exercise intensity (PritzlaV et al. 1999), volume (HoVman et al. 2003), duration (Stokes et al. 2002), work/rest ratio (Kraemer et al. 1990), and amount of muscle mass recruited (Hansen et al. 2001).”
BackgroundHip and Knee Kinetics During a Back Squat and Deadlift
Choe, K. H., Coburn, J. W., Costa, P. B., & Pamukoff, D. N. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002908 · Cited by 41 · see citing works
The Effects of Short-Cycle Sprints on Power, Strength, and Salivary Hormones in Elite Rugby Players
Crewther, B. T., Cook, C. J., Lowe, T. E., Weatherby, R. P., & Gill, N. (2011) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181b6045c · Cited by 38 · see citing works
“Intense exercise has also been used to elevate testosterone and/or cortisol concentrations during individual workouts and achieve greater training adaptation (18,26).”
BackgroundPescatello, L. S., Kelsey, B. K., Price, T. B., Seip, R. L., Angelopoulos, T. J., Clarkson, P. M., Gordon, P. M., Moyna, N. M., Visich, P. S., Zoeller, R. F., et al. (2007) · The Journal of Strength and Conditioning Research · doi:10.1519/r-22236.1 · Cited by 43 · see citing works
“(15) found increased amounts of circulating growth hormone were positively related to gains in muscle strength and size to RT among young, untrained men who were normal weight.”
BackgroundAcute Salivary Hormone Responses to Complex Exercise Bouts
Beaven, C. M., Gill, N. D., Ingram, J. R., & Hopkins, W. G. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181bf4414 · Cited by 39 · see citing works
“Hansen et al (16) also concluded that increases in isometric strength were related to the magnitude of testosterone response to resistance exercise in young men.”
BackgroundAlegre, L. M., Jódar, X. A., Rojas‐Martín, D., Martín‐García, M., Ara, I., & Csapo, R. (2014) · Muscle & Nerve · doi:10.1002/mus.24271 · Cited by 38 · see citing works
Effect of Lower-Body Resistance Training on Upper-Body Strength Adaptation in Trained Men
Bartolomei, S., Hoffman, J. R., Stout, J. R., & Merni, F. (2016) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001639 · Cited by 37 · see citing works
Cadore, E. L., Pinheiro, E. D. S., Izquierdo, M., Correa, C. S., Radaelli, R., Martins, J. B., Lhullier, F. L. R., Laitano, O., Cardoso, M., & Pinto, R. S. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828c32de · Cited by 35 · see citing works
“Although testosterone responses to resistance exercise have been postulated as an important factor to optimize strength and hypertrophy (4,12,19,30), the role of this hormone in power development during plyometric training needs to be investigated further.”
BackgroundA Comparison of Techniques for Estimating Training-Induced Changes in Muscle Cross-Sectional Area
DeFreitas, J. M., Beck, T. W., Stock, M. S., Dillon, M. A., Sherk, V. D., Stout, J. R., & Cramer, J. T. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181ec86f3 · Cited by 36 · see citing works
“(5) have shown there is a significantly greater growth hormone response when a combination of upper- and lower-body exercises is performed, and Mulligan et al.”
BackgroundHill, E. C., Housh, T. J., Keller, J. L., Smith, C. M., Anders, J. P. V., Schmidt, R. J., Johnson, G. O., & Cramer, J. T. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04287-3 · Cited by 35 · see citing works
“Regardless, there appears to be an additive effect when additional muscle groups are trained within a resistance training intervention (Hansen et al. 2001; Madarame et al. 2008; Bartolomei et al. 2018).”
InfluentialEklund, D., Schumann, M., Kraemer, W. J., Izquierdo, M., Taipale, R. S., & Häkkinen, K. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001022 · Cited by 34 · see citing works
“Although it has been suggested that tissue exposure to acute elevations in anabolic hormones would not be associated with hypertrophy or strength performance (47), such correlations have been demonstrated in male populations after pure strength training (22,31).”
BackgroundLuk, H., Levitt, D. E., Boyett, J. C., Rojas, S., Flader, S. M., McFarlin, B. K., & Vingren, J. L. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00473.2018 · Cited by 33 · see citing works
“, muscle size, strength) (19, 50), and the nature of these RE-induced hormones might contribute to the sexual dimorphism observed in muscle hypertrophic adaptation to resistance training.”
BackgroundInfluentialHayes, L. D., Sculthorpe, N. F., Young, J. D., Baker, J. S., & Grace, F. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0368-6 · Cited by 32 · see citing works
“associated with chronic adaptations to exercise training [7, 17].”
BackgroundAcute Oxygen Uptake and Resistance Exercise Performance Using Different Rest Interval Lengths
Ratamess, N. A., Rosenberg, J. G., Kang, J., Sundberg, S., Izer, K. A., Levowsky, J., Rzeszutko, C., Ross, R. E., & Faigenbaum, A. D. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000485 · Cited by 32 · see citing works
“, elbow flexors) during resistance training (11,27).”
BackgroundExercise and Regulation of Protein Metabolism
Atherton, P. J., Phillips, B. E., & Wilkinson, D. J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.06.015 · Cited by 34 · see citing works
Popov, D. V., Lysenko, E. A., Bachinin, A. V., Miller, T. F., Kurochkina, N. S., Kravchenko, I. V., Furalyov, V. A., & Vinogradova, O. L. (2015) · Muscle & Nerve · doi:10.1002/mus.24314 · Cited by 32 · see citing works
“We used the exercise of small muscle mass (bilateral leg extension2flexion), because the secretion of anabolic hormones depends on the muscle mass involved.(20,21) This approach allowed us to avoid exercise-induced blood hormone increases that could influence ana-”
MethodUltradian rhythmicity and induced changes in salivary testosterone
Beaven, C. M., Ingram, J. R., Gill, N. D., & Hopkins, W. G. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1518-3 · Cited by 28 · see citing works
“Indeed, the contribution of testosterone and cortisol in realising the adaptive responses to resistance exercise have been previously reported ( Hansen et al. 2001; Bird et al. 2006; Kvorning et al. 2006; Beaven et al. 2008a).”
BackgroundAlterations in IGF-I affect elderly: role of physical activity
Sagiv, M., Chen, Y., Amir, R., & Nir, Y. (2007) · European Review of Aging and Physical Activity · doi:10.1007/s11556-007-0022-1 · Cited by 27 · see citing works
“While a few studies have reported no change in resting levels of IGF-I after short-term resistance training [40, 56, 99], other studies have shown elevations in IGF-I during short/long-term resistance-training programs [88, 91], particularly during high-volume training [61, 72].”
The Acute Hormonal Response to the Kettlebell Swing Exercise
Budnar, R. G., Duplanty, A. A., Hill, D. W., McFarlin, B. K., & Vingren, J. L. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000474 · Cited by 28 · see citing works
“amounts of muscle mass or resulting in greater volume of work elicit a larger hormonal response than those using a smaller amount of muscle mass (12,25,38).”
BackgroundResultInfluentialSkeletal Muscle Physiology: Plasticity and Responses to Exercise
Kraemer, W. J., & Spiering, B. A. (2006) · Hormone Research in Paediatrics · doi:10.1159/000096617 · Cited by 26 · see citing works
“The importance of the hormonal response to exercise was cleverly demonstrated by Hansen et al. [”
BackgroundO’Leary, C. B., & Hackney, A. C. (2014) · Physiological Research · doi:10.33549/physiolres.932627 · Cited by 26 · see citing works
“This finding could be particularly applicable for hypothesizing what response might occur in obese individuals, as both aging (Harman et al. 2001) and obesity (Traish et al. 2009) can lower basal testosterone.”
BackgroundInfluence of upper-body exercise order on hormonal responses in trained men
Junior, R. F. S., Leite, R. D., Speretta, G. F. F., Maior, A. S., de Salles, B. F., de Souza, T. P., Vingren, J. L., & Willardson, J. M. (2013) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2012-0040 · Cited by 24 · see citing works
Demura, S., Yamada, T., Yamaji, S., et al. (2010) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2010.11002 · Cited by 23 · see citing works
“The range of elbow joint motions for the concentric part was fully extended from 145 to 155°, flexed and means velocities for one repetition including concentric and eccentric motions were in a range of 100-150°/s [13].”
BackgroundMoradi, F. (2015) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.23808 · Cited by 22 · see citing works
“While it has been reported that serum testosterone levels reduce in endurance trained men (18), the few available findings about the effect of resistance training on circulating testosterone levels are controversial (20-27).”
BackgroundSmilios, I., Tsoukos, P., Zafeiridis, A., Spassis, A. T., & Tokmakidis, S. P. (2013) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2013-0147 · Cited by 21 · see citing works
“Changes in hormonal concentrations following a resistanceexercise session contribute to the regulation of long-term neuromuscular adaptations (Hansen et al. 2001; Kvorning et al. 2006; Rønnestad et al. 2011).”
BackgroundInfluentialVillanueva, M., Villanueva, M. G., Lane, C. J., & Schroeder, E. T. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182651fbe · Cited by 20 · see citing works
Igf-I and fgf-2 responses to wingate anaerobic test in older men.
Amir, R., Ben‐Sira, D., & Sagiv, M. (2007) · PubMed Central · Cited by 19 · see citing works
Crewther, B. T., Lowe, T. E., Weatherby, R. P., & Gill, N. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0978-1 · Cited by 18 · see citing works
“Greater training gains from resistance exercise combinations that produced the highest testosterone and cortisol responses during workouts have also been demonstrated ( Hansen et al. 2001; Madarame et al. 2008).”
BackgroundInfluentialČurović, I. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1549609 · Cited by 20 · see citing works
Macaluso, F., Morici, G., Catanese, P., Ardizzone, N. M., Gammazza, A. M., Bonsignore, G., Giudice, G. L., Stampone, T., Barone, R., Farina, F., et al. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318231ab78 · Cited by 18 · see citing works
“when the muscle is exposed to the anabolic hormone only for a short period (13).”
BackgroundNindl, B. C., Alemany, J. A., Rarick, K. R., Eagle, S. R., Darnell, M. E., Allison, K. F., & Harman, E. A. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.12.001 · Cited by 18 · see citing works
“A physiological significance of acute exercise-induced alterations in anabolic hormones favoring muscle hypertrophy have been suggested by some [14, 19, 20], and refuted by others [44].”
ResultWilk, M., Michalczyk, M. M., Gołaś, A., Krzysztofik, M., Maszczyk, A., & Zając, A. (2018) · Biology of Sport · doi:10.5114/biolsport.2018.75754 · Cited by 18 · see citing works
Crewther, B. T., Kilduff, L. P., & Cook, C. J. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0144-z · Cited by 18 · see citing works
“Physical exercise also provides an effective stimulus for increasing blood (free, total, bioavailable) T and Sal-T levels in men, including continuous running [11, 12], interval running [12, 13], sub-maximal and maximal cycling [14], and weight training [15, 16].”
BackgroundWest, D. J., Cunningham, D. J., Finn, C. V., Scott, P. M., Crewther, B. T., Cook, C. J., & Kilduff, L. P. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182948110 · Cited by 17 · see citing works
“The acute testosterone response is influenced by the muscle mass involved (17,42) and the intensity and volume of the exercise (34).”
BackgroundEffects of Strongman Training on Salivary Testosterone Levels in a Sample of Trained Men
Ghigiarelli, J. J., Sell, K. M., Raddock, J. M., & Taveras, K. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182578115 · Cited by 17 · see citing works
“However, a much larger body of evidence supports the integral role that the acute hormonal response to RE has on muscle hypertrophy (36,40) and its role in strength training adaptation (19,27).”
BackgroundSalivary testosterone and cortisol concentrations after two different resistance training exercises
Geisler, S., Aussieker, T., Paldauf, S., Scholz, S., Kurz, M., Jungs, S., Rissmeyer, M., Achtzehn, S., & Zinner, C. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.18.08786-8 · Cited by 17 · see citing works
Timón, R., Maynar-Mariño, M., Muñoz, D., Olcina, G. J., Caballero, M. J., & Mariño, J. I. M. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0319-1 · Cited by 17 · see citing works
“…is systematized, and the organism adapts to this intense mode of working, the hormone response seems to aVect the pituitary and the hypothalamus, releasing greater amounts of androgens and creating optimal conditions for the development of strength (Hansen et al. 2001; Kraemer et al. 1999, 1998).”
BackgroundInfluentialMolecular Regulators of Exercise-mediated Insulin Sensitivity in Non-obese Individuals
Almuraikhy, S., Doudin, A., Domling, A., Althani, A. A. J. F., & Elrayess, M. A. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18015 · Cited by 16 · see citing works
“94,95 Steroids are often eliminated from the body through a process called glu-curonidation, which involves the transfer of a polar moiety from UDP-glucuronate to steroids such as androsterone in various steroid target tissues and the liver.”
BackgroundWest, D. W. D., Cotie, L. M., Mitchell, C. J., Churchward‐Venne, T. A., MacDonald, M. J., & Phillips, S. M. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2012-0397 · Cited by 16 · see citing works
Effect of whole body vibration applied on upper extremity muscles
Gyulai, G., Rácz, L., Giminiani, R. D., et al. (2012) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.99.2012.005 · Cited by 16 · see citing works
Zemke, B., & WRIGHT, G. A. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3182221f96 · Cited by 16 · see citing works
“It has been demonstrated that exercises incorporating large musculature, such as that of strongman exercises, produce the greatest increases in anabolic hormones, leading to increases in muscular hypertrophy (9).”
BackgroundRaymond, L. M., Renshaw, D. W., & Duncan, M. J. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002862 · Cited by 15 · see citing works
“The acute hormonal response to resistance exercise may be relevant for longer term exercise adaptation because some studies have demonstrated greater increases in strength and muscle mass from training using exercises that elicit a greater hormonal response (10,18).”
BackgroundČurović, I., Rhodes, D., Alexander, J., & Harper, D. J. (2024) · Sports Medicine · doi:10.1007/s40279-024-02039-8 · Cited by 14 · see citing works
“Four studies included mixed-sex participants [22, 31, 43, 44], two included only female individuals [23, 45] and 18 involved only male individuals [16–18, 21, 24, 38, 46–55].”
BackgroundMethodInfluentialMagdi, H. R., Maroto‐Izquierdo, S., & Fernández, J. A. D. P. (2021) · Medicina · doi:10.3390/medicina57050445 · Cited by 14 · see citing works
Chronic Alcohol Intake, Resistance Training, and Muscle Androgen Receptor Content
Vingren, J. L., Koziris, L. P., Gordon, S. E., Kraemer, W. J., Turner, R. T., & Westerlind, K. C. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000176679.80555.cd · Cited by 14 · see citing works
“crease in several androgenic endocrine responses (17).”
The Bottom-Up Rise Strength Transfer in Elderly After Endurance and Resistance Training: The BURST
Pietrangelo, T., Bondi, D., Kinel, E., & Verratti, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01944 · Cited by 13 · see citing works
- Authors
- Hansen, S., Kvorning, T., Kjær, M., & Sjøgaard, G.
- Affiliations
- University of Southern Denmark (DK)
- Bispebjerg Hospital (DK)
- Corresponding author
- Sjøgaard, G.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 11
- Issue
- 6
- Pages
- 347-354
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W2155936654
- Cited by
- 203
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 2 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 12 · 2015: 10 · 2014: 18 · 2013: 12 · 2012: 11
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- resistance training, skeletal muscle strength, testosterone, growth hormone, cortisol, anabolic hormones, isometric strength, isokinetic strength, functional strength, leg training, hormonal response to exercise
- MeSH terms
- Adult, Hormones, Humans, Hydrocortisone, Male, Muscle Contraction, Time Factors, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal
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