The ability of oxytocin to induce short latency maternal behavior is dependent on peripheral anosmia.
Abstract
Nulliparous female Sprague-Dawley rats, cannulated in the left lateral ventricle, were ovariectomized and estrogen primed, then either rendered anosmic via intranasal irrigation with zinc sulfate or left with intact olfaction. Forty-eight hr later, after a 2-hr habituation to the test cage, these animals were injected with either intracerebroventricular oxytocin (400 ng in 2 microliter saline) or saline (2 microliter). Only the group receiving both zinc sulfate and oxytocin became maternal. Additionally, approximately one third of the olfaction-intact rats and none of the anosmic rats cannibalized the rat pups. These results are discussed in regard to discrepancies in the literature regarding oxytocin's role in inducing maternal behavior, as well as the functional connection of the olfactory and oxytocin systems.
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Neuropeptide neurons can release peptide from its entire surface area and can diffuse through the extracellular space due to long half-lives.
“Unlike classical neurotransmitters, which are released primarily at the synaptic cleft, neuropeptide neurons can release peptide from its entire surface area [131] and can diffuse through the extracellular space due to long half-lives.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [131]
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Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
- Authors
- Wamboldt, M. Z., & Insel, T. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Behavioral Neuroscience
- Published
- 1987
- Volume
- 101
- Issue
- 3
- Pages
- 439-441
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2014132034
- Cited by
- 89
- References
- 11
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 16 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, maternal behavior, anosmia, olfaction, zinc sulfate, cannibalism, intracerebroventricular administration, nulliparous women, olfactory system, neuroendocrine regulation of behavior
- MeSH terms
- Animals, Brain, Female, Injections, Intraventricular, Maternal Behavior, Oxytocin, Rats, Inbred Strains, Reaction Time, Smell, Rats
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