Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females
Open accessAbstract
Oxytocin (Oxt) and the Oxt receptor (Oxtr) are implicated in the onset of maternal behavior in a variety of species. Recently, we developed two Oxtr knockout lines: a total body knockout (Oxtr-/-) and a conditional Oxtr knockout (OxtrFB/FB) in which the Oxtr is lacking only in regions of the forebrain, allowing knockout females to potentially nurse and care for their biological offspring. In the current study, we assessed maternal behavior of postpartum OxtrFB/FB females toward their own pups and maternal behavior of virgin Oxtr-/- females toward foster pups and compared knockouts of both lines to wildtype (Oxtr+/+) littermates. We found that both Oxtr-/- and OxtrFB/FB females appear to have largely normal maternal behaviors. However, with first litters, approximately 40% of the OxtrFB/FB knockout dams experienced high pup mortality, compared to fewer than 10% of the Oxtr+/+ dams. We then went on to test whether or not this phenotype occurred in subsequent litters or when the dams were exposed to an environmental disturbance. We found that regardless of the degree of external disturbance, OxtrFB/FB females lost more pups on their first and second litters compared to wildtype females. Possible reasons for higher pup mortality in OxtrFB/FB females are discussed.
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Oxytocin signaling is important for normal displays of alloparental care.
“Thus, it appears that Oxt signaling is important for normal displays of alloparental care, which is consistent with its role in lowering the threshold for maternal care in rodents (53–56).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [54]
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Abbreviations Used for Major Brain Regions
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- Authors
- Macbeth, A. H., Stepp, J. E., Lee, H.-J., Young, W. S., & Caldwell, H. K.
- Affiliations
- National Institutes of Health (US)
- Kyungpook National University (KR)
- Kent State University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2010
- Volume
- 124
- Issue
- 5
- Pages
- 677-685
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC3175421
- OpenAlex
- W1973626461
- Cited by
- 98
- References
- 68
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 22 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (Z01-MH-002498-21)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- oxytocin receptor, conditional knockout, maternal behavior, pup mortality, oxytocin, postpartum women, foster care, environmental disturbance, litter size
- MeSH terms
- Animals, Animals, Newborn, Female, Male, Maternal Behavior, Mice, Inbred C57BL, Stress, Psychological, Prosencephalon, Receptors, Oxytocin, Mice, Knockout, Mice
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