Oxytocin mediates acquisition of maternally associated odor preferences in preweanling rat pups.
Abstract
Three studies assessed the role of central oxytocin systems in maternal affiliation in preweanling rats. Fifteen-day-old rats were found to approach on odor faster and spend more time in contact with an odor when it had been paired with the mother on the previous day than when the odor was not paired with the mother, provided that the pairing occurred after either intracerebral administration of oxytocin (0.5 microgram) or saline. However, if rats were administered an oxytocin antagonist (OTA) prior to odor-mother pairing, neither the decreased odor approach latency nor the increased odor preference was apparent in the odor-mother group. OTA treatment did not attenuate a single-trial odor aversion learning task, nor did it disrupt interaction with the anesthetized mother. Results are discussed in terms of a possible reward-satiety role for oxytocin in the infant-mother context.
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OT and OTR are present in the thymus, the organ where lymphocytes mature into T cells that are involved in the adaptive immune system.
“OT and OTR are present in the thymus, the organ where lymphocytes mature into T cells that are involved in the adaptive immune system [93].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [93]
The human OTR gene has a binding site for the inflammatory cytokine nucleofactor interleukin-6 (NF IL-6) and for acute-phase response elements, which are induced by infection or inflammation.
“The human OTR gene has a binding site for the inflammatory cytokine nucleofactor interleukin-6 (NF IL-6) and for acute-phase response elements, which are induced by infection or inflammation [[94] for review see [93]].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [93]
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- Authors
- Nelson, E., & Panksepp, J.
- Affiliations
- Bowling Green State University (US)
- ORCID
- Nelson, Eric
- Venue
- Behavioral Neuroscience
- Published
- 1996-06
- Volume
- 110
- Issue
- 3
- Pages
- 583-592
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2091972235
- Cited by
- 113
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- oxytocin, preweanling rats, oxytocin antagonist, mother-infant interaction, maternal behavior
- MeSH terms
- Animals, Animals, Newborn, Conditioning, Psychological, Cues, Female, Male, Maternal Behavior, Odorants, Oxytocin, Smell, Rats
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