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Inferior frontal gyrus activity triggers anterior insula response to emotional facial expressions.
Abstract
The observation of movies of facial expressions of others has been shown to recruit similar areas involved in experiencing one's own emotions: the inferior frontal gyrus (IFG), the anterior insula and adjacent frontal operculum (IFO). The causal link between activity in these 2 regions, associated with motor and emotional simulation, respectively, has remained unknown. Here using psychophysiological interaction and Granger Causality Modeling, we show that activity in the IFO is causally triggered by activity in the IFG, and that this effective connectivity is specific to the IFG. These findings shed new light on the intricate relationship between motor and affective components of emotional empathy.
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“Accordingly, one view of AIC function highlights its involvement in the subjective experience of arousal (feelings experienced as a result of an event or stimulus) [38–40].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [39]
Citations
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
Action recognition in the premotor cortex
Gallese, V., Fadiga, L., Fogassi, L., & Rizzolatti, G. (1996) · Brain · doi:10.1093/brain/119.2.593 · Cited by 4,968
Investigating Causal Relations by Econometric Models and Cross-Spectral Methods
Granger, C. W. J. (2010) · Essays in Econometrics · doi:10.1017/cbo9780511753978.002 · Cited by 4,762
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Mirror neurons and the simulation theory of mind-reading
Gallese, V (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01262-5 · Cited by 3,201
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
A unifying view of the basis of social cognition
GALLESE, V, KEYSERS, C., & RIZZOLATTI, G. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.002 · Cited by 2,236
Self-citationBoth of Us Disgusted in My Insula
Wicker, B., Keysers, C., Plailly, J., Royet, J.-P., Gallese, V., & Rizzolatti, G. (2003) · Neuron · doi:10.1016/s0896-6273(03)00679-2 · Cited by 2,185
Self-citationMeasurement of Linear Dependence and Feedback between Multiple Time Series
Geweke, J. (1982) · Journal of the American Statistical Association · doi:10.1080/01621459.1982.10477803 · Cited by 2,060
Parietal Lobe: From Action Organization to Intention Understanding
Fogassi, L., Ferrari, P. F., Gesierich, B., Rozzi, S., Chersi, F., & Rizzolatti, G. (2005) · Science · doi:10.1126/science.1106138 · Cited by 1,990
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978
Looking for Spinoza : Joy, Sorrow, and the Feeling Brain
Damásio, A. R. (2003) · Dominican Scholar (Dominican University of California) · Cited by 1,879
Hearing Sounds, Understanding Actions: Action Representation in Mirror Neurons
Kohler, E., Keysers, C., Umiltà, M. A., Fogassi, L., Gallese, V., & Rizzolatti, G. (2002) · Science · doi:10.1126/science.1070311 · Cited by 1,801
Self-citationEmpathic neural responses are modulated by the perceived fairness of others
Singer, T., Seymour, B., O'Doherty, J. P., Stephan, K. E., Dolan, R. J., & Frith, C. D. (2006) · Nature · doi:10.1038/nature04271 · Cited by 1,726
Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2006) · Nature Neuroscience · doi:10.1038/nn1611 · Cited by 1,694
The Neural Substrate of Human Empathy: Effects of Perspective-taking and Cognitive Appraisal
Lamm, C., Batson, C. D., & Decety, J. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.1.42 · Cited by 1,464
How do we perceive the pain of others? A window into the neural processes involved in empathy
Jackson, P. L., Meltzoff, A. N., & Decety, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.006 · Cited by 1,257
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214
Mapping directed influence over the brain using Granger causality and fMRI
Roebroeck, A. F., Formisano, E., & Goebel, R. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.017 · Cited by 1,012
Impaired recognition and experience of disgust following brain injury
Calder, A. J., Keane, J., Manes, F., Antoun, N., & Young, A. W. (2000) · Nature Neuroscience · doi:10.1038/80586 · Cited by 850
Keysers, C. (2004) · doi:10.1016/s0896-6273(04)00156-4 · Cited by 806
Self-citationEmpathy and the somatotopic auditory mirror system in humans
Gazzola, V., Aziz-Zadeh, L., & Keysers, C. (2006) · Current Biology · doi:10.1016/j.cub.2006.07.072 · Cited by 752
Self-citationFerrari, P. F., Gallese, V., Rizzolatti, G., & Fogassi, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02601.x · Cited by 728
Goebel, R., Roebroeck, A. F., Kim, D., & Formisano, E. (2003) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.08.026 · Cited by 678
James, W. (1977) · Williams & Wilkins eBooks · doi:10.1037/10735-001 · Cited by 661
Simulationist models of face-based emotion recognition
Goldman, A. I., & Sripada, C. S. (2005) · Cognition · doi:10.1016/j.cognition.2004.01.005 · Cited by 647
Testing anatomically specified hypotheses in functional imaging using cytoarchitectonic maps
Eickhoff, S. B., Heim, S., Zilles, K., & Amunts, K. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.204 · Cited by 643
Somatosensory activations during the observation of touch and a case of vision–touch synaesthesia
Blakemore, S.-J., Bristow, D., Bird, G., Frith, C., & Ward, J. (2005) · Brain · doi:10.1093/brain/awh500 · Cited by 614
Empathy for positive and negative emotions in the gustatory cortex
Jabbi, M., Swart, M., & Keysers, C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.032 · Cited by 590
Self-citationViewing facial expressions of pain engages cortical areas involved in the direct experience of pain
Botvinick, M., Jha, A. P., Bylsma, L. M., Fabian, S., Solomon, P. E., & Prkachin, K. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.043 · Cited by 589
Integrating simulation and theory of mind: from self to social cognition
Keysers, C., & Gazzola, V. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.02.002 · Cited by 530
Self-citationFunctional imaging of face and hand imitation: towards a motor theory of empathy
Leslie, K. R., Johnson-Frey, S. H., & Grafton, S. T. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.038 · Cited by 514
Dissociable neural systems for recognizing emotions
Adolphs, R., Tranel, D., & Damásio, A. R. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00009-5 · Cited by 501
Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?
Morrison, I., Lloyd, D., Di Pellegrino, G., & Roberts, N. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.2.270 · Cited by 490
Empathy and Judging Other's Pain: An fMRI Study of Alexithymia
Moriguchi, Y., Decety, J., Ohnishi, T., Maeda, M., Mori, T., Nemoto, K., Matsuda, H., & Komaki, G. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl130 · Cited by 488
Human feelings: why are some more aware than others?
Craig, A. D. (. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.04.004 · Cited by 445
The Compassionate Brain: Humans Detect Intensity of Pain from Another's Face
Saarela, M. V., Hlushchuk, Y., Williams, A. C. D. C., Schurmann, M., Kalso, E., & Hari, R. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj141 · Cited by 441
Audiovisual mirror neurons and action recognition
Keysers, C., Kohler, E., Umilt�, M. A., Nanetti, L., Fogassi, L., & Gallese, V. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1603-5 · Cited by 420
Self-citationThe social context of nonverbal behavior
Philippot, P., Feldman, R. S., & Coats, E. J. (1999) · Éditions de la Maison des sciences de l’homme eBooks · Cited by 401
Mirroring others' emotions relates to empathy and interpersonal competence in children
Pfeifer, J. H., Iacoboni, M., Mazziotta, J. C., & Dapretto, M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.032 · Cited by 396
Lanzetta, J. T., & Englis, B. G. (1989) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.56.4.543 · Cited by 377
Towards a unifying neural theory of social cognition
Keysers, C., & Gazzola, V. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)56021-2 · Cited by 367
Self-citationOrofacial somatomotor responses in the macaque monkey homologue of Broca's area
Petrides, M., Cadoret, G., & Mackey, S. (2005) · Nature · doi:10.1038/nature03628 · Cited by 337
Stress, affiliation, and emotional contagion.
Gump, B. B., & Kulik, J. A. (1997) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.72.2.305 · Cited by 334
Distress crying in neonates: Species and peer specificity.
Martin, G. B., & Clark, R. D. (1982) · Developmental Psychology · doi:10.1037/0012-1649.18.1.3 · Cited by 327
To what extent do we share the pain of others? Insight from the neural bases of pain empathy.
Jackson, P. L., Rainville, P., & Decety, J. (2006) · Pain · doi:10.1016/j.pain.2006.09.013 · Cited by 326
Facial expressions: What the mirror neuron system can and cannot tell us
van der Gaag, C., Minderaa, R. B., & Keysers, C. (2007) · Social Neuroscience · doi:10.1080/17470910701376878 · Cited by 314
Self-citationA common neural basis for receptive and expressive communication of pleasant facial affect
Hennenlotter, A., Schröeder, U., Erhard, P., Castrop, F., Haslinger, B., Stöcker, D., Lange, K. W., & Ceballos-Baumann, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.057 · Cited by 231
Mimicry and the Judgment of Emotional Facial Expressions
Blairy, S., Herrera, P., & Heß, U. (1999) · Journal of Nonverbal Behavior · doi:10.1023/a:1021370825283 · Cited by 200
Aplasics Born without Hands Mirror the Goal of Hand Actions with Their Feet
Gazzola, V., van der Worp, H., Mulder, T., Wicker, B., Rizzolatti, G., & Keysers, C. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.045 · Cited by 200
Self-citationStandardized mood induction with happy and sad facial expressions
Schneider, F. W., Gur, R. C., Gur, R. E., & Muenz, L. R. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90044-2 · Cited by 181
Modulation of Emotional Appraisal by False Physiological Feedback during fMRI
Gray, M. A., Harrison, N. A., Wiens, S., & Critchley, H. D. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000546 · Cited by 170
The effect of attitudes on emotional reactions to expressive displays of political leaders
McHugo, G. J., Lanzetta, J. T., & Bush, L. K. (1991) · Journal of Nonverbal Behavior · doi:10.1007/bf00997765 · Cited by 138
The Neuronal Basis of Empathy and Fairness
Singer, T. (2006) · Novartis Foundation symposium · doi:10.1002/9780470030585.ch3 · Cited by 64
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Gazzola, V., & Keysers, C. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn181 · Cited by 740
Self-citationThe role of anterior insular cortex in social emotions
Lamm, C., & Singer, T. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0251-3 · Cited by 566
Goldman, A. I., & de Vignemont, F. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.01.007 · Cited by 423
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Self-citation
Metadata
- Authors
- Jabbi, M., & Keysers, C.
- Affiliations
- University of Groningen (NL)
- Venue
- Emotion
- Published
- 2008
- Volume
- 8
- Issue
- 6
- Pages
- 775-780
- ISSN
- 1528-3542 (ISSN-L)
- 1931-1516
- OpenAlex
- W2104602827
- Cited by
- 190
- References
- 55
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 27 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 13 · 2013: 13 · 2012: 11
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Emotion (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- European Commission
- Dutch Science Foundation (NWO)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- inferior frontal gyrus, anterior insula, frontal operculum, emotional facial expressions, affective empathy, motor simulation, effective connectivity, causal connectivity, Granger causality, psychophysiological interaction
- MeSH terms
- Affect, Cerebral Cortex, Facial Expression, Frontal Lobe, Humans, Magnetic Resonance Imaging, Taste
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