Maintenance of persistent activity in a frontal thalamocortical loop
Open accessAbstract
Persistent neural activity maintains information that connects past and future events. Models of persistent activity often invoke reverberations within local cortical circuits, but long-range circuits could also contribute. Neurons in the mouse anterior lateral motor cortex (ALM) have been shown to have selective persistent activity that instructs future actions. The ALM is connected bidirectionally with parts of the thalamus, including the ventral medial and ventral anterior-lateral nuclei. We recorded spikes from the ALM and thalamus during tactile discrimination with a delayed directional response. Here we show that, similar to ALM neurons, thalamic neurons exhibited selective persistent delay activity that predicted movement direction. Unilateral photoinhibition of delay activity in the ALM or thalamus produced contralesional neglect. Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity. Similarly, photoinhibition of the ALM diminished thalamic activity. Our results show that the thalamus is a circuit hub in motor preparation and suggest that persistent activity requires reciprocal excitation across multiple brain areas.
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Persistent-activity reverberatory loops involve not only corticocortical connections but also subcortical regions, especially the thalamus and cerebellar nuclei.
“recent experimental evidence indicates that the reverberatory loops for persistent neuronal activity not only involve corticocortical interactions but also loop through subcortical regions with an important role for the thalamus and cerebellar nuclei (Gao et al., 2018; Guo et al., 2017).”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Guo et al., 2017
The Discussion and Abstract support a role for a recurrent cortex–thalamus loop in maintaining persistent activity. The Discussion also identifies input from deep cerebellar nuclei to the thalamus, but says the roles of those more complex loops remain unresolved; it does not establish an important role for cerebellar nuclei in maintaining persistent activity. The supplied passages have no page numbers. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRecent evidence in rodents shows that persistence of neuronal firing rates for working memory storage is not purely cortical but relies on interactions with subcortical structures including thalamus and cerebellar nuclei.
“Recent evidence in rodents demonstrated that the persistence of neuronal firing rates for working memory storage is not a purely cortical phenomenon but instead relies on the interactions with subcortical structures, including the thalamus (Guo et al., 2017) and cerebellar nuclei (Gao et al., 2018).”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Guo et al., 2017
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- Authors
- Guo, Z. V., Inagaki, H. K., Daie, K., Druckmann, S., Gerfen, C. R., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Corresponding author
- Svoboda, Karel
- ORCID
- Venue
- Nature
- Published
- 2017-05
- Volume
- 545
- Issue
- 7653
- Pages
- 181-186
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6431254
- OpenAlex
- W2611542631
- Cited by
- 529
- References
- 61
- Citations by year
- 2026: 33 · 2025: 35 · 2024: 63 · 2023: 81 · 2022: 53 · 2021: 63 · 2020: 72 · 2019: 64 · 2018: 53 · 2017: 12
- FWCI
- 31.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- persistent activity, thalamocortical loop, anterior lateral motor cortex, thalamus, photoinhibition, tactile discrimination, motor preparation, recurrent excitation
- MeSH terms
- Animals, Female, Male, Motor Cortex, Movement, Neurons, Thalamus, Touch, Mice
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