Cited by 11,566Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., Collingridge, G. L.·1993·Nature

DOI 10.1038/361031a0

Open this paper in CoChat — free account

Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.

Integrity signals

Registry

Crossref · 10.1038/361031a0

Cites

169 of 169 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Self-citation
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Self-citation
Nitric oxide, a novel neuronal messenger
Bredt, D. S., & Snyder, S. H. (1992) · Neuron · doi:10.1016/0896-6273(92)90104-l · Cited by 1,852
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
Sommer, B., Köhler, M., Sprengel, R., & Seeburg, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90568-j · Cited by 1,517
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
Malinow, R., Schulman, H., & Tsien, R. W. (1989) · Science · doi:10.1126/science.2549638 · Cited by 1,325
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
Sommer, B., KEINÄNEN, K. P., Verdoorn, T. A., Wisden, W., Burnashev, N., Herb, A., Köhler, M. G., Takagi, T., Sakmann, B. J., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.1699275 · Cited by 1,272
The Neurobiology of Learning and Memory
Thompson, R. F. (1986) · Science · doi:10.1126/science.3738519 · Cited by 1,164

Flagged first, then by citations

Show all 169 references

Research works printed but not linked: 6

Hebb, D. O. The Organization of Behaviour (Wiley, New York, 1949).
Konorski, J. Conditioned Reflexes and Neuron Organisation (Cambridge Univ. Press, Cambridge, 1948).
Bliss, T. V. P. & Lømo, T. J. Physiol., Lond. 232, 331–356 (1973). · DOI · Paper page
Collingridge, G. L. et al. Int. Acad. Biomed. Drug Res. 2, 41–49 (1991).
Voronin, L. L., Kuhnt, U. & Gusev, A. G. Expl Brain Res. 89, 288–299 (1992).
Fazeli, M. S., Corbet, J., Dunn, M, J., Dolphin, A. C. & Bliss, T. V. P. J. Neurosci. 13(4) (in the press).

Sorted by citations

Items 401–500 of 1,220

Bidirectional modulation of synaptic functions by Eph/ephrin signaling
Klein, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2231 · Cited by 431
LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites
Frick, A., Magee, J. C., & Johnston, D. (2004) · Nature Neuroscience · doi:10.1038/nn1178 · Cited by 431
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
Barad, M., Bourtchouladze, R., Winder, D. G., Golan, H. M., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15020 · Cited by 430
Allosteric Receptors after 30 Years
Changeux, J., & Edelstein, S. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80616-9 · Cited by 430
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience
Kirkwood, A., Lee, H., & Bear, M. F. (1995) · Nature · doi:10.1038/375328a0 · Cited by 430
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
Son, H., Hawkins, R. D., Martin, K. C., Kiebler, M. A., Huang, P. L., Fishman, M. C., & Kandel, E. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81796-1 · Cited by 430
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429
Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines
Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 429
Self-citation
Role of Hippocampal Cav1.2 Ca2+Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory
Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stieß, M., Marais, E., Schulla, V., Lacinová, Ľ., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1531-05.2005 · Cited by 429
Hydrogen Sulfide as a Neuromodulator
Kimura, H. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:1:013 · Cited by 427
Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity
Woodin, M. A., Ganguly, K., & Poo, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00507-5 · Cited by 427
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 427
Reactive oxygen species and synaptic plasticity in the aging hippocampus
Serrano, F., & Klann, E. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.002 · Cited by 426
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms
Pell, G. S., Roth, Y., & Zangen, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.003 · Cited by 423
Disinhibition, a Circuit Mechanism for Associative Learning and Memory
Letzkus, J. J., Wolff, S. B. E., & Lüthi, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.024 · Cited by 430
Actions of TNF‐α on glutamatergic synaptic transmission in the central nervous system
Pickering, M., Cumiskey, D., & O'Connor, J. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030734 · Cited by 421
The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events
Anderson, W. W., & Collingridge, G. L. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00374-0 · Cited by 420
Self-citation
Memristors for Energy‐Efficient New Computing Paradigms
Jeong, D. S., Kim, K. M., Kim, S., Choi, B. J., & Hwang, C. S. (2016) · Advanced Electronic Materials · doi:10.1002/aelm.201600090 · Cited by 419
The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease
Amidfar, M., de Oliveira, J., Kucharska, E., Budni, J., & Kim, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118020 · Cited by 419
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear ExtinctionPreprint
Sotres-Bayón, F., Bush, D. E. A., & LeDoux, J. E. (2004) · Learning & Memory · doi:10.1101/lm.79504 · Cited by 419
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 418
Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity
Shanley, L. J., Irving, A. J., & Harvey, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-j0001.2001 · Cited by 417
Choline, a Vital Amine
Blusztajn, J. K. (1998) · Science · doi:10.1126/science.281.5378.794 · Cited by 417
Fibroblast growth factors and their receptors in the central nervous system
Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 417
Mathematical formulations of Hebbian learning
Wulfram Gerstner, B., & Kistler, W. M. (2002) · Biological Cybernetics · doi:10.1007/s00422-002-0353-y · Cited by 415
Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity
Hölscher, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01065-5 · Cited by 414
Postsynaptic Membrane Fusion and Long-Term Potentiation
Lledo, P.-M., Zhang, X., Südhof, T. C., Malenka, R. C., & Nicoll, R. A. (1998) · Science · doi:10.1126/science.279.5349.399 · Cited by 413
Place Learning and Hippocampal Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats
Biessels, G. J., Kamal, A., Ramakers, G. M. J., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1996) · Diabetes · doi:10.2337/diab.45.9.1259 · Cited by 413
Stimulation on the Positive Phase of Hippocampal Theta Rhythm Induces Long-Term Potentiation That Can Be Depotentiated by Stimulation on the Negative Phase in Area CA1 In Vivo
Hölscher, C., Anwyl, R., & Rowan, M. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-16-06470.1997 · Cited by 411
Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex
Egger, V., Feldmeyer, D., & Sakmann, B. J. (1999) · Nature Neuroscience · doi:10.1038/16026 · Cited by 411
Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus
Lü, Y.-F., Kandel, E. R., & Hawkins, R. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10250.1999 · Cited by 411
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410
New and evolving concepts in the neurotoxicology of lead☆
White, L. D., Cory‐Slechta, D. A., Gilbert, M. E., Tiffany‐Castiglioni, E., Zawia, N. H., Virgolini, M. B., Rossi‐George, A., Lasley, S. M., Qian, Y., & Basha, R. M. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.08.001 · Cited by 409
What is memory? The present state of the engram
Poo, M.-M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L., Tsien, R. W., Fishell, G., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0261-6 · Cited by 409
Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408
Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain
Tingley, W. G., Roche, K. W., Thompson, A. K., & Huganir, R. L. (1993) · Nature · doi:10.1038/364070a0 · Cited by 408
Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons
McDermott, C. M., LaHoste, G. J., Chen, C., Musto, A., Bazan, N. G., & Magee, J. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09687.2003 · Cited by 407
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS
O’Dell, T. J., Huang, P. L., Dawson, T. M., DINERMAN, J. L., Snyder, S. H., Kandel, E. R., & Fishman, M. C. (1994) · Science · doi:10.1126/science.7518615 · Cited by 407
Synaptic plasticity of NMDA receptors: mechanisms and functional implications
Hunt, D. L., & Castillo, P. E. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.01.007 · Cited by 405
Role of retinoid signalling in the adult brain
Lane, M. A., & Bailey, S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.03.002 · Cited by 405
Deficient Cerebellar Long-Term Depression, Impaired Eyeblink Conditioning, and Normal Motor Coordination in GFAP Mutant Mice
Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J. J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Katoh, A., Ikeda, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80078-1 · Cited by 405
The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB
Xu, B., Gottschalk, W., Chow, A., Wilson, R. I., Schnell, E., Zang, K., Wang, D., Nicoll, R. A., Lu, B., & Reichardt, L. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06888.2000 · Cited by 404
Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
Kaar, S. J., Natesan, S., McCutcheon, R. A., & Howes, O. D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107704 · Cited by 404
Stress: metaplastic effects in the hippocampus
Kim, J. J., & Yoon, K. S. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01322-8 · Cited by 403
Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1784-10.2010 · Cited by 402
Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.
Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.683 · Cited by 401
Assessment of spatial memory in mice
Sharma, S., Rakoczy, S. G., & Brown‐Borg, H. M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.004 · Cited by 399
High Affinity Glutamate Transporters: Regulation of Expression and Activity
Gegelashvili, G., & Schousboe, A. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.1.6 · Cited by 399
Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation
Murphy, K. P. S. J., Carter, R. J., Lione, L. A., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B., & Morton, A. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05115.2000 · Cited by 398
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas
Morris, R. G. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04888.x · Cited by 398
Cellular Imaging ofzif268Expression in the Hippocampus and Amygdala during Contextual and Cued Fear Memory Retrieval: Selective Activation of Hippocampal CA1 Neurons during the Recall of Contextual Memories
Hall, J., Thomas, K. L., & Everitt, B. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02186.2001 · Cited by 398
Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones
Murphy, D. D., & Segal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04059.1996 · Cited by 398
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih
Fan, Y., Fricker, D., Brager, D. H., Chen, X., Lu, H., Chitwood, R. A., & Johnston, D. (2005) · Nature Neuroscience · doi:10.1038/nn1568 · Cited by 397
Is plasticity of synapses the mechanism of long-term memory storage?
Abraham, W. C., Jones, O. D., & Glanzman, D. L. (2019) · npj Science of Learning · doi:10.1038/s41539-019-0048-y · Cited by 398
Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.001 · Cited by 396
Simultaneous Induction of Pathway-Specific Potentiation and Depression in Networks of Cortical Neurons
Jimbo, Y., Tateno, T., & Robinson, H. P. C. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77234-6 · Cited by 396
Biological Mechanisms of Physical Activity in Preventing Cognitive Decline
Lista, I., & Sorrentino, G. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9488-x · Cited by 396
Impaired interleukin‐1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
Avital, A., Goshen, I., Kamsler, A., Segal, M., Iverfeldt, K., Richter‐Levin, G., & Yirmiya, R. (2003) · Hippocampus · doi:10.1002/hipo.10135 · Cited by 396
Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro
Kerr, J. N. D., & Wickens, J. R. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.117 · Cited by 395
Identification of the Ca2+/Calmodulin-dependent Protein Kinase II Regulatory Phosphorylation Site in the α-Amino-3-hydroxyl-5-methyl4-isoxazole-propionate-type Glutamate Receptor
Barría, A., Derkach, V. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32727 · Cited by 395
Perceptual Correlates of Nociceptive Long-Term Potentiation and Long-Term Depression in Humans
Klein, T., Magerl, W., Hopf, H.-C., Sandkühler, J., & Treede, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1222-03.2004 · Cited by 395
Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems
Joëls, M., & de Kloet, E. R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90014-0 · Cited by 394
Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus
Bellinger, F. P., Madamba, S. G., & Siggins, G. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90959-q · Cited by 393
Artificial Synapses with Short- and Long-Term Memory for Spiking Neural Networks Based on Renewable Materials
Park, Y., & Lee, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b03347 · Cited by 394
Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins
Greger, I. H., Watson, J. F., & Cull-Candy, S. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.009 · Cited by 392
Atomic Switch: Atom/Ion Movement Controlled Devices for Beyond Von‐Neumann Computers
Hasegawa, T., Terabe, K., Tsuruoka, T., & Aono, M. (2011) · Advanced Materials · doi:10.1002/adma.201102597 · Cited by 391
Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights
Kaffman, A., & Meaney, M. J. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01730.x · Cited by 391
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?
Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 390
Expression, control, and probable functional significance of the neuronal theta-rhythm
Vinogradova, O. S. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00051-i · Cited by 386
Long-term memory and synapse-like dynamics in two-dimensional nanofluidic channels
Robin, P., Emmerich, T., Ismail, A., Niguès, A., You, Y., Nam, G., Keerthi, A., Siria, A., Geim, A. K., Radha, B., et al. (2023) · Science · doi:10.1126/science.adc9931 · Cited by 386
Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- d -aspartate receptor
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Ishii, S., & Shimizu, T. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00016-8 · Cited by 385
N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats.
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1365 · Cited by 385
General anaesthetic actions on ligand-gated ion channels
Krasowski, M. D., & Harrison, N. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050371 · Cited by 384
G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
Lu, W.-Y., Xiong, Z.-G., Lei, S., Orser, B. A., Dudek, E. M., Browning, M. D., & MacDonald, J. F. (1999) · Nature Neuroscience · doi:10.1038/7243 · Cited by 384
Increasing Numbers of Synaptic Puncta during Late-Phase LTP
Bozdagi, O., Shan, W., Tanaka, H., Benson, D. L., & Huntley, G. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)00100-8 · Cited by 384
Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation
Müller‐Dahlhaus, J. F. M., Orekhov, Y., Liu, Y., & Ziemann, U. (2008) · Experimental Brain Research · doi:10.1007/s00221-008-1319-7 · Cited by 384
Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice
Trinchese, F., Liu, S., Battaglia, F., Walter, S., Mathews, P. M., & Arancio, O. (2004) · Annals of Neurology · doi:10.1002/ana.20101 · Cited by 384
Is Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory
Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382
The sequential hypothesis of the function of sleep
Giuditta, A., Ambrosini, M. V., Montagnese, P., Mandile, P., Cotugno, M., Zucconi, G. G., & Vescia, S. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00012-i · Cited by 382
Ligand affinities at recombinant receptors depend on subunit composition
Laurie, D., & Seeburg, P. H. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90058-2 · Cited by 382
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
Munoz, L., & Ammit, A. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.010 · Cited by 381
Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice
Méziane, H., Dodart, J., Mathis, C., Little, S. H., Clemens, J. A., Paul, S. M., & Ungerer, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12683 · Cited by 379
Nuclear calcium signalling in the regulation of brain function
Bading, H. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3531 · Cited by 381
Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
Biessels, G. J., Kamal, A., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00510-1 · Cited by 377
Hippocampal synaptic plasticity: role in spatial learning or the automatic recording of attended experience?
Morris, R., & Frey, U. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0136 · Cited by 375
Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus
Gazzaley, A. H., Weiland, N. G., McEwen, B. S., & Morrison, J. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06830.1996 · Cited by 375
Regulation of Hippocampal Transmitter Release During Development and Long-Term Potentiation
Bolshakov, V. Y., & Siegelbaum, S. A. (1995) · Science · doi:10.1126/science.7569903 · Cited by 375
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373
Epigenetic regulation of memory formation and maintenancePreprint
Zovkic, I. B., Karlsson, M. G., & Sweatt, J. D. (2013) · Learning & Memory · doi:10.1101/lm.026575.112 · Cited by 371
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370
Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex
Xu, H., Wu, L.-J., Wang, H., Zhang, X., Vadakkan, K. I., Kim, S. S., Steenland, H. W., & Zhuo, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1812-08.2008 · Cited by 370
Dendritic coincidence detection of EPSPs and action potentials
Stuart, G. J., & Häusser, M. (2001) · Nature Neuroscience · doi:10.1038/82910 · Cited by 369
Common pathological processes in Alzheimer disease and type 2 diabetes: A review
Li, L., & Hölscher, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.001 · Cited by 367
Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. II. Fasciclin II Controls Presynaptic Structural Plasticity
Schuster, C., Davis, G. W., Fetter, R. D., & Goodman, C. S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80198-1 · Cited by 367
The use of fura-2 for estimating ca buffers and ca fluxes
Neher, E. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00144-u · Cited by 367
Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/3589271 · Cited by 370
CREB: A mediator of long-term memory from mollusks to mammals
Frank, D. A., & Greenberg, M. E. (1994) · Cell · doi:10.1016/0092-8674(94)90394-8 · Cited by 366

Authors: Bliss, T. V. P., & Collingridge, G. L.
Affiliations: National Institute for Medical Research (GB)
ORCID: Collingridge, G. L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-01
Volume: 361
Issue: 6407
Pages: 31-39
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/361031a0
OpenAlex: W2049511526
Cited by: 11,566
References: 169
Citations by year: 2026: 154 · 2025: 254 · 2024: 254 · 2023: 299 · 2022: 252 · 2021: 321 · 2020: 308 · 2019: 312 · 2018: 347 · 2017: 361 · 2016: 354 · 2015: 377 · 2014: 390 · 2013: 384 · 2012: 371
FWCI: 34.50
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, hippocampus, synaptic plasticity, memory, learning, NMDA receptor, glutamate receptors, Hebbian learning, synaptic transmission, postsynaptic mechanisms
MeSH terms: Animals, Calcium, Electrophysiology, Evoked Potentials, Hippocampus, Memory, Models, Neurological, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A synaptic model of memory: long-term potentiation in the hippocampus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks