Cited by 3,837Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and TreatmentsTelomeres, Telomerase, and Senescence

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko, Kaname, Tadashi, Kume, Eisuke, Iwasaki, Hitoshi, Iida, Akihiro, Shiraki-Iida, Takako, Nishikawa, Satoshi, Nagai, Ryozo, Nabeshima, Yo-ichi·1997·Nature

DOI 10.1038/36285

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Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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Authors: Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
Affiliations: Gunma University (JP)
The University of Tokyo (JP)
Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
National Center of Neurology and Psychiatry (JP)
Corresponding author: Nabeshima, Yo-ichi
ORCID: Matsumura, Yutaka
Aizawa, Hiroki
Kawaguchi, Hiroshi
Kurabayashi, Masahiko
Kaname, Tadashi
Iwasaki, Hitoshi
Nishikawa, Satoshi
Nagai, Ryozo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-11-06
Volume: 390
Issue: 6655
Pages: 45-51
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/36285
OpenAlex: W2114360920
Cited by: 3,837
References: 26
Citations by year: 2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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