Cited by 3,837Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and TreatmentsTelomeres, Telomerase, and Senescence

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko, Kaname, Tadashi, Kume, Eisuke, Iwasaki, Hitoshi, Iida, Akihiro, Shiraki-Iida, Takako, Nishikawa, Satoshi, Nagai, Ryozo, Nabeshima, Yo-ichi·1997·Nature

DOI 10.1038/36285

Open this paper in CoChat — free account

Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

Integrity signals

Registry

Crossref · 10.1038/36285

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A new method for predicting signal sequence cleavage sites
von HEIJNE, G. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.11.4683 · Cited by 4,473
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
The Bloom's syndrome gene product is homologous to RecQ helicases
Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. E. L. (1990) · Elsevier eBooks · doi:10.1016/c2013-0-11470-5 · Cited by 1,219
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.
Uberbacher, E. C., & Mural, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11261 · Cited by 652
Osteoporosis: Etiology, diagnosis, and management
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80791-1 · Cited by 605

Flagged first, then by citations

Show all 26 references

Research works printed but not linked: 4

Robbins, S. L., Angell, M. A. & Kumar, V. in Basic Pathology 3–27 (Igaku-shoin/Saunders, Tokyo, 1981).
Chuttani, A. & Gilchrest, B. A. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 309–324 (Oxford Univ. Press, New York, 1995).
Sparrow, D. & Weiss, S. T. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 475–483 (Oxford Univ. Press, New York, 1995).
Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning (Cold Spring Harbor Laboratory Press, New York, 1989).

Sorted by citations

Items 1,001–1,100 of 1,647

Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002145 · Cited by 276
Nuclear genomic instability and aging
Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012239 · Cited by 275
BCL-2 family: integrating stress responses at the ER to control cell demise
Pihán, P., Carreras-Sureda, A., & Hetz, C. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.82 · Cited by 274
A selective gut bacterial bile salt hydrolase alters host metabolism
Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S. (2018) · eLife · doi:10.7554/elife.37182 · Cited by 274
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Heo, Y., Kim, S., Seo, C. I., Kim, Y. K., Sung, B., Lee, H. S., Lee, J. I., Park, S., Kim, J. H., Hwang, K. Y., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600212 · Cited by 275
Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation
Testa, G., Staurenghi, E., Zerbinati, C., Gargiulo, S., Iuliano, L., Giaccone, G., Fantò, F., Poli, G., Leonarduzzi, G., & Gamba, P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.001 · Cited by 270
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
Hirsova, P., Ibrabim, S. H., Gores, G. J., & Malhi, H. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066357 · Cited by 270
Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors
Weiss, J. M., Davies, L. C., Karwan, M., Ileva, L., Ozaki, M. K., Cheng, R. Y. S., Ridnour, L. A., Annunziata, C. M., Wink, D. A., & McVicar, D. W. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99169 · Cited by 267
A 3D human neural cell culture system for modeling Alzheimer's disease
Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., et al. (2015) · Nature Protocols · doi:10.1038/nprot.2015.065 · Cited by 269
Platelet factors attenuate inflammation and rescue cognition in ageing
Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K. K., Bieri, G., Horowitz, A. M., Smith, L. K., Encabo, K., Tenggara, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06436-3 · Cited by 252
Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain
Goeden, N., Velasquez, J., Arnold, K. A., Chan, Y., Lund, B. T., Anderson, G. M., & Bonnin, A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2534-15.2016 · Cited by 264
Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism
Filice, F., Vörckel, K. J., Sungur, A. Ö., Wöhr, M., & Schwaller, B. (2016) · Molecular Brain · doi:10.1186/s13041-016-0192-8 · Cited by 240
Calcium and phosphate homeostasis: Concerted interplay of new regulators
Renkema, K. Y., Alexander, R. T., Bindels, R. J., & Hoenderop, J. G. (2008) · Annals of Medicine · doi:10.1080/07853890701689645 · Cited by 263
Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)
Cox, L. E., Ferraiuolo, L., Goodall, E. F., Heath, P. R., Higginbottom, A., Mortiboys, H., Hollinger, H. C., Hartley, J. A., Brockington, A., Burness, C. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009872 · Cited by 262
The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer
Melissaridou, S., Wiechec, E., Magan, M., Jain, M. V., Chung, M. K., Farnebo, L., & Roberg, K. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0733-1 · Cited by 262
Depletion of Human DNA in Spiked Clinical Specimens for Improvement of Sensitivity of Pathogen Detection by Next-Generation Sequencing
Hasan, M. R., Rawat, A., Tang, P., Jithesh, P. V., Thomas, E., Tan, R., & Tilley, P. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.03050-15 · Cited by 243
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
Llambi, F., Wang, Y.-M., Victor, B., Yang, M., Schneider, D. M., Gingras, S., Parsons, M. J., Zheng, J. H., Brown, S. A., Pelletier, S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.026 · Cited by 261
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Ajoolabady, A., Lindholm, D., Ren, J., & Pratico, D. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05153-5 · Cited by 261
Emerging models and paradigms for stem cell ageing
Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256
Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial
Goldfine, A. B., Fonseca, V., Jablonski, K. A., Chen, Y.-D. I., Tipton, L., Staten, M. A., & Shoelson, S. E. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-1-201307020-00003 · Cited by 251
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.141 · Cited by 236
Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition
Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1748-05.2005 · Cited by 251
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis
Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Mohlke, K. L., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005027 · Cited by 248
Effects of IGF-1 isoforms on muscle growth and sarcopenia
Ascenzi, F., Barberi, L., Dobrowolny, G., Villa Nova Bacurau, A., Nicoletti, C., Rizzuto, E., Rosenthal, N., Scicchitano, B. M., & Musarò, A. (2019) · Aging Cell · doi:10.1111/acel.12954 · Cited by 250
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review
Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248
MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation
Aucher, A., Rudnicka, D., & Davis, D. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301728 · Cited by 247
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human
Coutton, C., Vargas, A. S., Amiri-Yekta, A., Kherraf, Z.-E., Ben Mustapha, S. F., Le Tanno, P., Wambergue-Legrand, C., Karaouzène, T., Martinez, G., Crouzy, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02792-7 · Cited by 245
The maintenance of memory plasma cells
Khodadadi, L., Cheng, Q., Radbruch, A., & Hiepe, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00721 · Cited by 232
Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease
Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
Hernández-Gea, V., Hilscher, M., Rozenfeld, R., Lim, M. P., Nieto, N., Werner, S., Devi, L. A., & Friedman, S. L. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.016 · Cited by 236
Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip
Shen, F., Davydova, E. K., Du, W., Kreutz, J. E., Piepenburg, O., & Ismagilov, R. F. (2011) · Analytical Chemistry · doi:10.1021/ac200247e · Cited by 240
A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer
Eustace, A., Mani, N., Span, P. N., Irlam, J. J., Taylor, J., Betts, G. N. J., Denley, H., Miller, C. J., Homer, J. J., Rojas, A. M., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0542 · Cited by 240
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia
Bell, E. L., Klimova, T. A., Eisenbart, J., Schumacker, P. T., & Chandel, N. S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02265-06 · Cited by 237
Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis
Tu, L. N., Morohaku, K., Manna, P. R., Pelton, S. H., Butler, W. R., Stocco, D. M., & Selvaraj, V. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578286 · Cited by 239
MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., & Jahn, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126423 · Cited by 236
An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation
Kim, M.-S., Akhtar, M. W., Adachi, M., Mahgoub, M., Bassel-Duby, R., Kavalali, E. T., Olson, E. N., & Monteggia, L. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2089-12.2012 · Cited by 235
Colorectal tumor-on-a-chip system: a 3D tool for precision onco-nanomedicine
Carvalho, M. R., Barata, D., Teixeira, L. M., Giselbrecht, S., Reis, R. L., Oliveira, J. M., Truckenmüller, R., & Habibovic, P. (2019) · Science Advances · doi:10.1126/sciadv.aaw1317 · Cited by 230
Genetic Engineering of the Calvin Cycle toward Enhanced Photosynthetic CO2 Fixation in Microalgae
Yang, B., Liu, J., Ma, X., Guo, B., Liu, B., Wu, T., Jiang, Y., & Chen, F. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0916-8 · Cited by 231
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
Forman, H. J., Fukuto, J. M., Miller, T., Zhang, H., Rinna, A., & Levy, S. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.011 · Cited by 226
AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9
Li, A., Tanner, M. R., Lee, C. M., Hurley, A. E., De Giorgi, M., Jarrett, K. E., Davis, T. H., Doerfler, A. M., Bao, G., Beeton, C., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.04.017 · Cited by 230
Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation
Elmore, M. R. P., Lee, R. J., West, B. L., & Green, K. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122912 · Cited by 228
Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1
Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., & Loskutoff, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6902 · Cited by 226
Muscle releases alpha-sarcoglycan positive extracellular vesicles carrying miRNAs in the bloodstream
Guescini, M., Canonico, B., Lucertini, F., Maggio, S., Annibalini, G., Barbieri, E., Luchetti, F., Papa, S., & Stocchi, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125094 · Cited by 228
Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel
Beck, E. C., Barragan, M., Tadros, M. H., Gehrke, S. H., & Detamore, M. S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.019 · Cited by 222
Smooth Muscle Enriched Long Noncoding RNA ( SMILR ) Regulates Cell Proliferation
Ballantyne, M. D., Pinel, K., Dakin, R., Vesey, A. T., Diver, L., Mackenzie, R., Garcia, R., Welsh, P., Sattar, N., Hamilton, G., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.021019 · Cited by 223
Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria
Martínez-del Campo, A., Bodea, S., Hamer, H. A., Marks, J. A., Haiser, H. J., Turnbaugh, P. J., & Balskus, E. P. (2015) · mBio · doi:10.1128/mbio.00042-15 · Cited by 224
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero, B., Bourdenx, M., Luengo, E., Diaz, A., Sohn, P. D., Chen, X., Wang, C., Juste, Y. R., Wegmann, S., Patel, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22501-9 · Cited by 223
Developmental alterations in Huntington’s disease neural cells and pharmacological rescue in cells and mice
The HD iPSC Consortium, Lim, R. G., Salazar, L. L., Wilton, D. K., King, A. R., Stocksdale, J. T., Sharifabad, D., Lau, A. L., Stevens, B., Reidling, J. C., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4532 · Cited by 221
Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs
Van Etten, J., Schagat, T. L., Hrit, J., Weidmann, C. A., Brumbaugh, J., Coon, J. J., & Goldstrohm, A. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.373522 · Cited by 205
Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell · doi:10.1016/j.cell.2007.02.049 · Cited by 222
Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation
Ishimura, R., Nagy, G., Dotu, I., Chuang, J. H., & Ackerman, S. L. (2016) · eLife · doi:10.7554/elife.14295 · Cited by 221
Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly
YAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.013 · Cited by 214
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
MacArthur, J. M., Bishop, J. R., Stanford, K. I., Wang, L., Bensadoun, A., Witztum, J. L., & Esko, J. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29154 · Cited by 216
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement
Sun, Y., Bak, B., Schoenmakers, N., van Trotsenburg, A. S. P., Oostdijk, W., Voshol, P., Cambridge, E., White, J. K., le Tissier, P., Gharavy, S. N. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2453 · Cited by 217
Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
Rayagiri, S. S., Ranaldi, D., Raven, A., Mohamad Azhar, N. I. F., Lefebvre, O., Zammit, P. S., & Borycki, A.-G. (2018) · Nature Communications · doi:10.1038/s41467-018-03425-3 · Cited by 218
Epicardial adipose tissue as a metabolic transducer: Role in heart failure and coronary artery disease
Patel, V. B., Shah, S., Verma, S., & Oudit, G. Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9644-1 · Cited by 218
Root Damage under Alkaline Stress Is Associated with Reactive Oxygen Species Accumulation in Rice (Oryza sativa L.)
Zhang, H., Liu, X.-L., Zhang, R.-X., Yuan, H.-Y., Wang, M.-M., Yang, H.-Y., Ma, H.-Y., Liu, D., Jiang, C.-J., & Liang, Z.-W. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01580 · Cited by 218
An overview of technical considerations when using quantitative real-time PCR analysis of gene expression in human exercise research
Kuang, J., Yan, X., Genders, A. J., Granata, C., & Bishop, D. J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196438 · Cited by 207
Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death
Maharjan, P. S., & Bhattarai, H. K. (2022) · Journal of Oncology · doi:10.1155/2022/7211485 · Cited by 222
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
Pao, P.-C., Patnaik, D., Watson, L. A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H. P., Huang, W.-C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16361-y · Cited by 216
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
Park, J.-H., Ju, Y. H., Choi, J. W., Song, H. J., Jang, B. K., Woo, J., Chun, H., Kim, H. J., Shin, S. J., Yarishkin, O., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav0316 · Cited by 216
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Min, D., Panoskaltsis-Mortari, A., Kuro-o, M., Holländer, G. A., Blazar, B. R., & Weinberg, K. I. (2007) · Blood · doi:10.1182/blood-2006-08-043794 · Cited by 214
Self-citation
Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
O’Brien, K. P., Khan, S., Gilligan, K. E., Zafar, H., Lalor, P., Glynn, C., O’Flatharta, C., Ingoldsby, H., Dockery, P., De Bhulbh, A., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0116-9 · Cited by 215
Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men
Boden, G., Homko, C., Barrero, C. A., Stein, T. P., Chen, X., Cheung, P., Fecchio, C., Koller, S., & Merali, S. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac4765 · Cited by 214
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death
Liu, S., Sarkar, C., Dinizo, M., Faden, A. I., Koh, E. Y., Lipinski, M. M., & Wu, J. (2015) · Cell Death & Disease · doi:10.1038/cddis.2014.527 · Cited by 209
P2Y12 expression and function in alternatively activated human microglia
Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000080 · Cited by 212
Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis
Hsu, H.-S., Liu, C.-C., Lin, J.-H., Hsu, T.-W., Hsu, J.-W., Su, K., & Hung, S.-C. (2017) · Scientific Reports · doi:10.1038/s41598-017-14612-5 · Cited by 205
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210
American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models: Report of the American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action
Bianco, A. C., Anderson, G., Forrest, D., Galton, V. A., Gereben, B., Kim, B. W., Kopp, P. A., Liao, X. H., Obregon, M. J., Peeters, R. P., et al. (2014) · Thyroid · doi:10.1089/thy.2013.0109 · Cited by 205
Engineering of Saccharomyces cerevisiae for Efficient Anaerobic Alcoholic Fermentation of l -Arabinose
Wisselink, H. W., Toirkens, M. J., del Rosario Franco Berriel, M., Winkler, A. A., van Dijken, J. P., Pronk, J. T., & van Maris, A. J. A. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00177-07 · Cited by 209
Induction of an IFN-mediated antiviral response by a self-amplifying RNA vaccine: implications for vaccine design
Pepini, T., Pulichino, A.-M., Carsillo, T., Carlson, A. L., Sari-Sarraf, F., Ramsauer, K., Debasitis, J. C., Maruggi, G., Otten, G. R., Geall, A. J., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601877 · Cited by 208
Three dimensional printed macroporous polylactic acid/hydroxyapatite composite scaffolds for promoting bone formation in a critical-size rat calvarial defect model
Zhang, H., Mao, X., Du, Z., Jiang, W., Han, X., Zhao, D., Han, D., & Li, Q. (2016) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2016.1145532 · Cited by 208
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208
Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
V'kovski, P., Gerber, M., Kelly, J., Pfaender, S., Ebert, N., Braga Lagache, S., Simillion, C., Portmann, J., Stalder, H., Gaschen, V., et al. (2019) · eLife · doi:10.7554/elife.42037 · Cited by 186
A human neurodevelopmental model for Williams syndrome
Chailangkarn, T., Trujillo, C. A., Freitas, B. C., Hrvoj-Mihic, B., Herai, R. H., Yu, D. X., Brown, T. T., Marchetto, M. C., Bardy, C., McHenry, L., et al. (2016) · Nature · doi:10.1038/nature19067 · Cited by 195
High fat diet, gut microbiome and gastrointestinal cancer
Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C. (2021) · Theranostics · doi:10.7150/thno.56157 · Cited by 205
Omega-3 Fatty Acids and Skeletal Muscle Health
Jeromson, S., Gallagher, I., Galloway, S., & Hamilton, D. (2015) · Marine Drugs · doi:10.3390/md13116977 · Cited by 203
The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress
Bermejo, C., Rodríguez, E., García, R., Rodríguez-Peña, J. M., Rodríguez de la Concepción, M. L., Rivas, C., Arias, P., Nombela, C., Posas, F., & Arroyo, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0742 · Cited by 204
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
Below, C. R., Kelly, J., Brown, A., Humphries, J. D., Hutton, C., Xu, J., Lee, B. Y., Cintas, C., Zhang, X., Hernandez-Gordillo, V., et al. (2022) · Nature Materials · doi:10.1038/s41563-021-01085-1 · Cited by 194
The potential role of amyloid in the pathogenesis of age-related macular degeneration
Yoshida, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24635 · Cited by 202
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204
“model which could be genetically rescued by exoge1384 nous expression of klotho cDNA [346].”
Background
Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance
Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., et al. (2014) · Diabetes · doi:10.2337/db13-0967 · Cited by 201
The dynamic plasticity of insulin production in β-cells
Boland, B. B., Rhodes, C. J., & Grimsby, J. S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.010 · Cited by 194
Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder
Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.175 · Cited by 199
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
Chen, H.-J., Lin, C.-M., Lin, C.-S., Perez-Olle, R., Leung, C. L., & Liem, R. K. H. (2006) · Genes & Development · doi:10.1101/gad.1411206 · Cited by 191
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo
Simeone, R., Sayes, F., Song, O., Gröschel, M. I., Brodin, P., Brosch, R., & Majlessi, L. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004650 · Cited by 198
Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome
Paniagua, J. A. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.483 · Cited by 197
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
Stutzbach, L. D., Xie, S. X., Naj, A. C., Albin, R., Gilman, S., PSP Genetics Study Group, Lee, V. M. Y., Trojanowski, J. Q., Devlin, B., & Schellenberg, G. D. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-31 · Cited by 197
Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons
Mardinly, A. R., Spiegel, I., Patrizi, A., Centofante, E., Bazinet, J. E., Tzeng, C. P., Mandel-Brehm, C., Harmin, D. A., Adesnik, H., Fagiolini, M., et al. (2016) · Nature · doi:10.1038/nature17187 · Cited by 176
DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age
Kim, H., Chang, J., Shao, L., Han, L., Iyer, S., Manolagas, S. C., O'Brien, C. A., Jilka, R. L., Zhou, D., & Almeida, M. (2017) · Aging Cell · doi:10.1111/acel.12597 · Cited by 192
Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week
Nikodemova, M., Kimyon, R. S., De, I., Small, A. L., Collier, L. S., & Watters, J. J. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.018 · Cited by 192
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
Kaneto, H., Matsuoka, T.-A., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0640-x · Cited by 193
Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII
D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192
Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle
Wang, G., Biswas, A. K., Ma, W., Kandpal, M., Coker, C., Grandgenett, P. M., Hollingsworth, M. A., Jain, R., Tanji, K., Lόpez-Pintado, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0054-2 · Cited by 188
Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts
Lobo, F. P., Mota, B. E. F., Pena, S. D. J., Azevedo, V., Macedo, A. M., Tauch, A., Machado, C. R., & Franco, G. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006282 · Cited by 191
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
Matias, I., Diniz, L. P., Damico, I. V., Araujo, A. P. B., Neves, L. D. S., Vargas, G., Leite, R. E. P., Suemoto, C. K., Nitrini, R., Jacob‐Filho, W., et al. (2022) · Aging Cell · doi:10.1111/acel.13521 · Cited by 183
Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury
Peirs, C., Williams, S.-P. G., Zhao, X., Arokiaraj, C. M., Ferreira, D. W., Noh, M.-C., Smith, K. M., Halder, P., Corrigan, K. A., Gedeon, J. Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.027 · Cited by 190
In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
Suter, M., Abramovici, A., Showalter, L., Hu, M., Shope, C. D., Varner, M., & Aagaard-Tillery, K. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.013 · Cited by 188
Molecular bases of progeroid syndromes
Navarro, C. L., Cau, P., & Lévy, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl214 · Cited by 189

Authors: Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
Affiliations: Gunma University (JP)
The University of Tokyo (JP)
Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
National Center of Neurology and Psychiatry (JP)
Corresponding author: Nabeshima, Yo-ichi
ORCID: Matsumura, Yutaka
Aizawa, Hiroki
Kawaguchi, Hiroshi
Kurabayashi, Masahiko
Kaname, Tadashi
Iwasaki, Hitoshi
Nishikawa, Satoshi
Nagai, Ryozo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-11-06
Volume: 390
Issue: 6655
Pages: 45-51
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/36285
OpenAlex: W2114360920
Cited by: 3,837
References: 26
Citations by year: 2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks