Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko +8 more·1997·Nature

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    Yuan, Zhenjie, Chen, Yuxia, Chen, Qiuyue, Guo, Miao, Kang, Li, Zhu, Guiyu, Jiang, Yunliang · 2016 · G3 Genes Genomes Genetics
  3. Cellular Models of Aging and Senescence
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  5. Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated
    Villani, Guglielmo R. D., Chierchia, Armando, Di Napoli, Daniele, Di Natale, Paola · 2012 · Journal of Inherited Metabolic Disease
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    Zygmunt, Deborah A., Singhal, Neha, Kim, Mi-Lyang, Cramer, Megan L., Crowe, Kelly E., Xu, Rui, Jia, Ying, Adair, Jessica, Martinez-Pena y Valenzuela, Isabel, Akaaboune, Mohammed et al. · 2017 · Molecular and Cellular Biology
  7. β‑ecdysterone promotes autophagy and inhibits apoptosis in osteoporotic rats
    Tang, Yang‑Hua, Yue, Zhen‑Shuang, Xin, Da‑Wei, Zeng, Lin‑Ru, Xiong, Zhen‑Fei, Hu, Zhong‑Qing, Xu, Can‑Da · 2017 · Molecular Medicine Reports
  8. Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype
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  10. Loss of C-5 Sterol Desaturase Activity in <i>Candida albicans</i> : Azole Resistance or Merely Trailing Growth?
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  11. Effects of intermedin on proliferation, apoptosis and the expression of OPG/RANKL/M-CSF in the MC3T3-E1 osteoblast cell line
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  12. Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer
    Glassman, Deanna, Kim, Mark S., Spradlin, Meredith, Badal, Sunil, Taki, Mana, Bhattacharya, Pratip, Dutta, Prasanta, Kingsley, Charles V., Foster, Katherine I., Animasahun, Olamide et al. · 2023 · iScience
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    Zhang, Xiaoyan, Li, Shan, Luo, Haihua, He, Shuyue, Yang, Huangda, Li, Lei, Tian, Tian, Han, Qizheng, Ye, Jiacong, Huang, Chenyang et al. · 2022 · Signal Transduction and Targeted Therapy
  14. Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism
    Boonpattrawong, Nicha P., Golbidi, Saeid, Tai, Daven C., Aleliunas, Rika E., Bernatchez, Pascal, Miller, Joshua W., Laher, Ismail, Devlin, Angela M. · 2020 · Physiological Reports
  15. Impact of Water Activity on the Inactivation and Gene Expression of Listeria monocytogenes during Refrigerated Storage of Pressurized Dry-Cured Ham
    Pérez-Baltar, Aida, Alía, Alberto, Rodríguez, Alicia, Córdoba, Juan José, Medina, Margarita, Montiel, Raquel · 2020 · Foods
  16. Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression
    Saito, Mariko, O’Brien, Danielle, Kovacs, Krisztina M., Wang, Ray, Zavadil, Jiri, Vadasz, Csaba · 2005 · Neurochemical Research
  17. Co-expression of auxiliary genes enhances the activity of a heterologous O2-tolerant hydrogenase in the cyanobacterium Synechocystis sp. PCC 6803
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  18. Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats
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  19. Downregulation of miR‑21 suppresses 1‑methyl‑4‑phenylpyridinium‑induced neuronal damage in MES23.5 cells
    Mao, Huawu, Ding, Lidong · 2019 · Experimental and Therapeutic Medicine
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    Maza, Rodrigo M., Barreda-Manso, María Asunción, Reigada, David, Silván, Ágata, Muñoz-Galdeano, Teresa, Soto, Altea, del Águila, Ángela, Nieto-Díaz, Manuel · 2022 · Biomedicines
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    Carlson, Noel G., Bellamkonda, Satya, Schmidt, Linda, Redd, Jonathan, Huecksteadt, Thomas, Weber, Lauren Marissa, Davis, Ethan, Wood, Blair, Maruyama, Takayuki, Rose, John W. · 2015 · Journal of Neuroinflammation
  23. Alive and well? Exploring disease by studying lifespan
    Brett, Jamie O, Rando, Thomas A · 2014 · Current Opinion in Genetics &amp; Development
  24. Inflammation-Driven Molecular Ageing in Chronic Inflammatory Skin Diseases: Is There a Role for Biologic Therapies?
    Andrzejczak, Klara, Sternak, Agata, Witkowski, Wiktor, Ponikowska, Małgorzata · 2025 · Cells
  25. Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling
    Degani, Genny, Ragni, Enrico, Botias, Pedro, Ravasio, Davide, Calderon, Julia, Pianezzola, Elena, Rodriguez-Peña, Jose Manuel, Vanoni, Maria Antonietta, Arroyo, Javier, Fonzi, William A. et al. · 2016 · BMC Genomics
  26. Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives
    Cuinat, Silvestre, Bézieau, Stéphane, Deb, Wallid, Mercier, Sandra, Vignard, Virginie, Isidor, Bertrand, Küry, Sébastien, Ebstein, Frédéric · 2024 · Genes &amp; Diseases
  27. A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence
    Kang, Taekyu, Moore, Emily C, Kopania, Emily E K, King, Christina D, Schilling, Birgit, Campisi, Judith, Good, Jeffrey M, Brem, Rachel B · 2023 · G3: Genes, Genomes, Genetics
  28. An Integrated Analysis of Lactation-Related miRNA and mRNA Expression Profiles in Donkey Mammary Glands
    Fei, Yaqi, Gai, Yedan, Liao, Qingchao, Zhang, Linxi, Li, Zheng, Li, Bojiang, Bai, Man, Li, Na, Deng, Liang · 2022 · Genes
  29. The role of bmp- and fgf signaling modulating mouse proepicardium cell fate
    Garcia-Padilla, Carlos, Hernandez-Torres, Francisco, Lozano-Velasco, Estefania, Dueñas, Angel, Muñoz-Gallardo, Maria del Mar, Garcia-Valencia, Isabel S., Palencia-Vincent, Lledó, Aranega, Amelia, Franco, Diego · 2022 · Frontiers in Cell and Developmental Biology
  30. Cancerous inhibitor of protein phosphatase 2A regulates cisplatin resistance in ovarian cancer
    Li, Wanbin, Zhang, Hongyan, Yang, Linqing, Wang, Yunfei · 2018 · Oncology Letters
  31. Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system
    Walsh, Alexander D., Stone, Sarrabeth, Freytag, Saskia, Aprico, Andrea, Kilpatrick, Trevor J., Ansell, Brendan R. E., Binder, Michele D. · 2023 · Communications Biology
  32. Investigation of the underling mechanism of ketamine for antidepressant effects in treatment‑refractory affective disorders via molecular profile analysis
    Qiao, Jun, Sun, Yuan, Wu, Jinfang, Wang, Li · 2019 · Experimental and Therapeutic Medicine
  33. Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model
    Comeglio, P., Sarchielli, E., Filippi, S., Cellai, I., Guarnieri, G., Morelli, A., Rastrelli, G., Maseroli, E., Cipriani, S., Mello, T. et al. · 2021 · Journal of Endocrinological Investigation
  34. Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity
    Potes, Yaiza, Díaz-Luis, Andrea, Bermejo-Millo, Juan C., Pérez-Martínez, Zulema, de Luxán-Delgado, Beatriz, Rubio-González, Adrian, Menéndez-Valle, Iván, Gutiérrez-Rodríguez, José, Solano, Juan J., Caballero, Beatriz et al. · 2023 · Antioxidants
  35. Comparative Analysis of Two Candida parapsilosis Isolates Originating from the Same Patient Harbouring the Y132F and R398I Mutations in the ERG11 Gene
    Štefánek, Matúš, Garaiová, Martina, Valček, Adam, Jordao, Luisa, Bujdáková, Helena · 2023 · Cells
  36. Metabolomic alterations in mammary glands from pubertal mice fed a high-fat diet
    Yan, Lin, Rust, Bret M, Sundaram, Sneha, Bukowski, Michael R · 2023 · Nutrition and Metabolic Insights
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    Salem, Mai A., El-Gameel, Sohila M., Kamel, Mohamed S., Elsamman, Eslam M., Ramadan, Reem M. · 2025 · Parasites &amp; Vectors
  38. Construction of an easily detectable transgenic Synechococcus elongatus PCC 7942 against White Spot Syndrome Virus using vp28 and mOrange Gene and its metabolism in shrimp
    Peng, Wen, Bao, Qunjing, Jia, Rui, He, Peimin · 2022 · Frontiers in Immunology
  39. The role of miRNA-624-5p in congenital hypothyroidism and its molecular mechanism by targeting SIRT1.
    Wu, Wanli, Cao, Xuying, Wang, Yuhong · 2022 · Genes &amp; Genomics
  40. SAGA Complex Subunit Hfi1 Is Important in the Stress Response and Pathogenesis of Cryptococcus neoformans
    Yu, Chendi K., Stephenson, Christina J., Villamor, Tristan C., Dyba, Taylor G., Schulz, Benjamin L., Fraser, James A. · 2023 · Journal of Fungi
  41. ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation
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  42. Whole-Body Cryotherapy Alters Circulating MicroRNA Profile in Postmenopausal Women
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  43. Unraveling the mechanism of fragrance release in Cestrum nocturnum through transcriptome and volatile compound profiling
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