Cited by 3,837Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and TreatmentsTelomeres, Telomerase, and Senescence

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko, Kaname, Tadashi, Kume, Eisuke, Iwasaki, Hitoshi, Iida, Akihiro, Shiraki-Iida, Takako, Nishikawa, Satoshi, Nagai, Ryozo, Nabeshima, Yo-ichi·1997·Nature

DOI 10.1038/36285

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Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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A new method for predicting signal sequence cleavage sites
von HEIJNE, G. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.11.4683 · Cited by 4,473
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
The Bloom's syndrome gene product is homologous to RecQ helicases
Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. E. L. (1990) · Elsevier eBooks · doi:10.1016/c2013-0-11470-5 · Cited by 1,219
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.
Uberbacher, E. C., & Mural, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11261 · Cited by 652
Osteoporosis: Etiology, diagnosis, and management
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80791-1 · Cited by 605

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Robbins, S. L., Angell, M. A. & Kumar, V. in Basic Pathology 3–27 (Igaku-shoin/Saunders, Tokyo, 1981).
Chuttani, A. & Gilchrest, B. A. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 309–324 (Oxford Univ. Press, New York, 1995).
Sparrow, D. & Weiss, S. T. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 475–483 (Oxford Univ. Press, New York, 1995).
Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning (Cold Spring Harbor Laboratory Press, New York, 1989).

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Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
Cedernaes, J., Schönke, M., Westholm, J. O., Mi, J., Chibalin, A., Voisin, S., Osler, M., Vogel, H., Hörnaeus, K., Dickson, S. L., et al. (2018) · Science Advances · doi:10.1126/sciadv.aar8590 · Cited by 137
Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains
Bushman, D. M., Kaeser, G. E., Siddoway, B., Westra, J. W., Rivera, R. R., Rehen, S. K., Yung, Y. C., & Chun, J. (2015) · eLife · doi:10.7554/elife.05116 · Cited by 136
Genetic determinants of gut microbiota composition and bile acid profiles in mice
Kemis, J. H., Linke, V., Barrett, K. L., Boehm, F. J., Traeger, L. L., Keller, M. P., Rabaglia, M. E., Schueler, K. L., Stapleton, D. S., Gatti, D. M., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008073 · Cited by 136
Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain
Bellaver, B., Souza, D. G., Souza, D. O., & Quincozes-Santos, A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9880-8 · Cited by 135
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Sigg, M. A., Menchen, T., Lee, C., Johnson, J., Jungnickel, M. K., Choksi, S. P., Garcia, G., Busengdal, H., Dougherty, G. W., Pennekamp, P., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.014 · Cited by 130
Systemic corazonin signalling modulates stress responses and metabolism in Drosophila
Kubrak, O. I., Lushchak, O. V., Zandawala, M., & Nässel, D. R. (2016) · Open Biology · doi:10.1098/rsob.160152 · Cited by 134
Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization
Xu, L., & Ota, T. (2017) · Adipocyte · doi:10.1080/21623945.2017.1413516 · Cited by 134
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Bing, C. (2015) · Adipocyte · doi:10.4161/21623945.2014.979661 · Cited by 127
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Hashimoto, S., & Saido, T. C. (2018) · Open Biology · doi:10.1098/rsob.180024 · Cited by 129
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Zietek, T., & Rath, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00154 · Cited by 131
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Lim, S. M., Koraka, P., Osterhaus, A. D. M. E., & Martina, B. E. E. (2011) · Viruses · doi:10.3390/v3060811 · Cited by 133
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Watson, E., MacNeil, L. T., Arda, H. E., Zhu, L. J., & Walhout, A. J. M. (2013) · Cell · doi:10.1016/j.cell.2013.02.050 · Cited by 134
Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.
Tarantino, G., Citro, V., & Capone, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010015 · Cited by 134
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Casella, G., Colombo, F., Finardi, A., Descamps, H., Ill-Raga, G., Spinelli, A., Podini, P., Bastoni, M., Martino, G., Muzio, L., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.024 · Cited by 134
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Choi, Y., Lichterman, J. N., Coughlin, L. A., Poulides, N., Li, W., Del Valle, P., Palmer, S. N., Gan, S., Kim, J., Zhan, X., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.abo2003 · Cited by 132
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Wiederhold, N. P., Kontoyiannis, D. P., Prince, R. A., & Lewis, R. E. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.12.5146-5148.2005 · Cited by 131
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity
Leus, N. G. J., van der Wouden, P. E., van den Bosch, T., Hooghiemstra, W. T. R., Ourailidou, M. E., Kistemaker, L. E. M., Bischoff, R., Gosens, R., Haisma, H. J., & Dekker, F. J. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.010 · Cited by 131
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
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Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat
Chen, J., Xie, J.-J., Shi, K.-S., Gu, Y.-T., Wu, C.-C., Xuan, J., Ren, Y., Chen, L., Wu, Y.-S., Zhang, X.-L., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-017-0217-y · Cited by 130
COPs and POPs: modulators of inflammasome activity
Stehlik, C., & Dorfleutner, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.7993 · Cited by 130
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D'Adamo, S., Schiano di Visconte, G., Lowe, G., Szaub‐Newton, J., Beacham, T., Landels, A., Allen, M. J., Spicer, A., & Matthijs, M. (2019) · Plant Biotechnology Journal · doi:10.1111/pbi.12948 · Cited by 129
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Leon, J., Moreno, A. J., Garay, B. I., Chalkley, R. J., Burlingame, A. L., Wang, D., & Dubal, D. B. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.024 · Cited by 123
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Kao, A. C.-C., Spitzer, S., Anthony, D. C., Lennox, B., & Burnet, P. W. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0116-8 · Cited by 128
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Rolland-Fourcade, C., Denadai-Souza, A., Cirillo, C., Lopez, C., Jaramillo, J. O., Desormeaux, C., Cenac, N., Motta, J.-P., Larauche, M., Taché, Y., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312094 · Cited by 126
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Zamudio, S., Wu, Y., Ietta, F., Rolfo, A., Cross, A., Wheeler, T., Post, M., Illsley, N. P., & Caniggia, I. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.061185 · Cited by 124
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Wang, H.-N., Crawford, B. M., Fales, A. M., Bowie, M. L., Seewaldt, V. L., & Vo-Dinh, T. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.6b03299 · Cited by 124
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Authors: Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
Affiliations: Gunma University (JP)
The University of Tokyo (JP)
Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
National Center of Neurology and Psychiatry (JP)
Corresponding author: Nabeshima, Yo-ichi
ORCID: Matsumura, Yutaka
Aizawa, Hiroki
Kawaguchi, Hiroshi
Kurabayashi, Masahiko
Kaname, Tadashi
Iwasaki, Hitoshi
Nishikawa, Satoshi
Nagai, Ryozo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-11-06
Volume: 390
Issue: 6655
Pages: 45-51
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/36285
OpenAlex: W2114360920
Cited by: 3,837
References: 26
Citations by year: 2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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