Cited by 2,853Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Functional neurogenesis in the adult hippocampus

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van Praag, Henriette, Schinder, Alejandro F., Christie, Brian R., Toni, Nicolas, Palmer, Theo D., Gage, Fred H.·2002·Nature

DOI 10.1038/4151030aPMC PMC9284568

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Abstract

There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.

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Authors: van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: van Praag, Henriette
ORCID: van Praag, Henriette
Schinder, Alejandro F.
Christie, Brian R.
Toni, Nicolas
Palmer, Theo D.
Gage, Fred H.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-02
Volume: 415
Issue: 6875
Pages: 1030-1034
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/4151030a
PMC: PMC9284568
OpenAlex: W1963940970
Cited by: 2,853
References: 31
Citations by year: 2026: 28 · 2025: 52 · 2024: 48 · 2023: 45 · 2022: 55 · 2021: 84 · 2020: 105 · 2019: 90 · 2018: 79 · 2017: 126 · 2016: 130 · 2015: 120 · 2014: 144 · 2013: 142 · 2012: 151
FWCI: 35.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Mental Health (R01MH090258)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: adult neurogenesis, dentate gyrus, hippocampus, dentate gyrus granule cells, neuronal maturation, retroviral labeling, live imaging, neuronal morphology, action potential, synaptic input, passive membrane properties
MeSH terms: Aging, Animals, Cell Differentiation, Cell Division, Female, Genetic Vectors, Luminescent Proteins, Membrane Potentials, Mice, Inbred C57BL, Neural Pathways, Neurons, Synapses, Dentate Gyrus, Green Fluorescent Proteins, Mice

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