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Functional neurogenesis in the adult hippocampus
Open accessAbstract
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.
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“doublecortin (DCX), a protein expressed in developing immature neurons, but silenced as those neurons mature37”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [37]
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Metadata
- Authors
- van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- van Praag, Henriette
- ORCID
- Venue
- Nature
- Published
- 2002-02
- Volume
- 415
- Issue
- 6875
- Pages
- 1030-1034
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC9284568
- OpenAlex
- W1963940970
- Cited by
- 2,853
- References
- 31
- Citations by year
- 2026: 28 · 2025: 52 · 2024: 48 · 2023: 45 · 2022: 55 · 2021: 84 · 2020: 105 · 2019: 90 · 2018: 79 · 2017: 126 · 2016: 130 · 2015: 120 · 2014: 144 · 2013: 142 · 2012: 151
- FWCI
- 35.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH090258)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, hippocampus, dentate gyrus granule cells, neuronal maturation, retroviral labeling, live imaging, neuronal morphology, action potential, synaptic input, passive membrane properties
- MeSH terms
- Aging, Animals, Cell Differentiation, Cell Division, Female, Genetic Vectors, Luminescent Proteins, Membrane Potentials, Mice, Inbred C57BL, Neural Pathways, Neurons, Synapses, Dentate Gyrus, Green Fluorescent Proteins, Mice
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