Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

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Gold nanoparticles in delivery applications☆

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Progress and problems with the use of viral vectors for gene therapy

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New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

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Rational design of cationic lipids for siRNA delivery

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Delivery materials for siRNA therapeutics

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

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An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery

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mRNA vaccines — a new era in vaccinology

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Lipid nanoparticles for mRNA delivery

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

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The clinical progress of mRNA vaccines and immunotherapies

Barbier, A. J., Jiang, A. Y., Zhang, P., Wooster, R., & Anderson, D. G. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01294-2 · Cited by 823

Advances in mRNA Vaccines for Infectious Diseases

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Endosomal escape: A bottleneck for LNP-mediated therapeutics

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Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

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New Vaccine Technologies to Combat Outbreak Situations

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Clinical advances and ongoing trials of mRNA vaccines for cancer treatment

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Self-assembled mRNA vaccines

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Self-amplifying RNA vaccines for infectious diseases

Bloom, K., van den Berg, F., & Arbuthnot, P. (2021) · Gene Therapy · doi:10.1038/s41434-020-00204-y · Cited by 487

mRNA therapeutics in cancer immunotherapy

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COVID-19 vaccines: The status and perspectives in delivery points of view

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Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

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The interaction of innate immune and adaptive immune system

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Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy

Guevara, M. L., Persano, F., & Persano, S. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.589959 · Cited by 261

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

Zhang, H., Zhang, Y., & Yin, H. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.014 · Cited by 256

mRNA vaccines in disease prevention and treatment

Zhang, G., Tang, T., Chen, Y., Huang, X., & Liang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01579-1 · Cited by 273

Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

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Encapsulation state of messenger RNA inside lipid nanoparticles

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Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives

Gómez-Aguado, I., Rodríguez-Castejón, J., Vicente-Pascual, M., Rodríguez‐Gascón, A., Solinís, M. Á., & del Pozo‐Rodríguez, A. (2020) · Nanomaterials · doi:10.3390/nano10020364 · Cited by 229

mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo

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Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells

Kaczmarek, J. C., Kauffman, K. J., Fenton, O. S., Sadtler, K., Patel, A. K., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02917 · Cited by 218

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

Kwon, H., Kim, M., Seo, Y., Moon, Y. S., Lee, H. J., Lee, K., & Lee, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.034 · Cited by 208

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Blakney, A. K., McKay, P. F., Yus, B. I., Aldon, Y., & Shattock, R. J. (2019) · Gene Therapy · doi:10.1038/s41434-019-0095-2 · Cited by 206

Clinical and immunological effects of mRNA vaccines in malignant diseases

Heine, A., Juranek, S., & Brossart, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01339-1 · Cited by 186

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Qiu, Y., Man, R. C. H., Liao, Q., Kung, K. L. K., Chow, M. Y. T., & Lam, J. K. W. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.026 · Cited by 178

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Xia, W., Tao, Z., Zhu, B., Zhang, W., Liu, C., Chen, S., & Song, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179118 · Cited by 177

Nanoscale platforms for messenger RNA delivery

Li, B., Zhang, X., & Dong, Y. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1530 · Cited by 170

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

Blakney, A. K., Zhu, Y., McKay, P. F., Bouton, C. R., Yeow, J., Tang, J., Hu, K., Samnuan, K., Grigsby, C. L., Shattock, R. J., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00326 · Cited by 155

SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis

Velikova, T. V., & Georgiev, T. (2021) · Rheumatology International · doi:10.1007/s00296-021-04792-9 · Cited by 153

RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA

Leng, Q., Chen, L., & Lv, Y. (2020) · Theranostics · doi:10.7150/thno.42640 · Cited by 144

Cationic lipids for gene delivery: many players, one goal

Ponti, F., Campolungo, M., Melchiori, C., Bono, N., & Candiani, G. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2020.105032 · Cited by 146

Injectable Immunotherapeutic Hydrogel Containing RNA-Loaded Lipid Nanoparticles Reshapes Tumor Microenvironment for Pancreatic Cancer Therapy

Gao, C., Cheng, K., Li, Y., Gong, R., Zhao, X., Nie, G., & Ren, H. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01994 · Cited by 134

Local Delivery of Ox40l , Cd80 , and Cd86 mRNA Kindles Global Anticancer Immunity

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mRNA nanomedicine: Design and recent applications

Kubiatowicz, L. J., Mohapatra, A., Krishnan, N., Fang, R. H., & Zhang, L. (2022) · Exploration · doi:10.1002/exp.20210217 · Cited by 131

Lipid carriers for mRNA delivery

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X-ray-Based Techniques to Study the Nano–Bio Interface

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Biomedical applications of mRNA nanomedicine

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mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy

Deng, Z., Tian, Y., Song, J., An, G., & Yang, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.887125 · Cited by 130

Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity

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Efficient gene editing via non-viral delivery of CRISPR–Cas9 system using polymeric and hybrid microcarriers

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Systemic mRNA delivery to the lungs by functional polyester-based carriers

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Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair

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mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

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In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles

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Oral delivery of IL-22 mRNA-loaded lipid nanoparticles targeting the injured intestinal mucosa: A novel therapeutic solution to treat ulcerative colitis

Sung, J. J., Alghoul, Z., Long, D., Yang, C., & Merlin, D. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121707 · Cited by 103

Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration

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Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective

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Lipid nanoparticles: Composition, formulation, and application

Xu, S., Hu, Z., Song, F., Xu, Y. G., & Han, X. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101463 · Cited by 112

Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery

Benner, N. L., McClellan, R. L., Turlington, C. R., Haabeth, O. A. W., Waymouth, R. M., & Wender, P. A. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03154 · Cited by 98

Recent Advances and Challenges in Gene Delivery Mediated by Polyester-Based Nanoparticles

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Advancements in clinical RNA therapeutics: Present developments and prospective outlooks

Saw, P. E., & Song, E. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101555 · Cited by 97

Nucleic Acid Vaccines for COVID-19: A Paradigm Shift in the Vaccine Development Arena

Chavda, V. P., Hossain, M. M. M., Beladiya, J., & Apostolopoulos, V. (2021) · Biologics · doi:10.3390/biologics1030020 · Cited by 92

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

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Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

Versteeg, L., Almutairi, M. M., Hotez, P. J., & Pollet, J. B. K. (2019) · Vaccines · doi:10.3390/vaccines7040122 · Cited by 94

Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Siewert, C. D., Haas, H., Cornet, V., Nogueira, S. S., Nawroth, T., Uebbing, L., Ziller, A., Al-Gousous, J., Rădulescu, A., Schroer, M. A., et al. (2020) · Cells · doi:10.3390/cells9092034 · Cited by 92

A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery

Gerhardt, A., Voigt, E. A., Archer, M. C., Reed, S., Larson, E., Hoeven, N. V., Kramer, R. M., Fox, C. B., & Casper, C. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.03.009 · Cited by 86

Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

Wang, H., Lu, Q., Zhang, X., Guan, J., & Mao, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.061 · Cited by 90

Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

Golombek, S., Pilz, M., Steinle, H., Kochba, E., Levin, Y., Lunter, D., Schlensak, C., Wendel, H. P., & Avci-Adali, M. (2018) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2018.03.005 · Cited by 88

Self-assembled polymeric micelle as a novel mRNA delivery carrier

Ren, J., Cao, Y., Li, L., Wang, X., Lü, H., Yang, J., & Wang, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.061 · Cited by 86

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Wang, Y., Song, H., Yu, M., Xu, C., Liu, Y., Tang, J., Yang, Y., & Yu, C. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00544c · Cited by 85

Lipid Polymer Hybrid Nanomaterials for mRNA Delivery

Zhao, W., Zhang, C., Li, B., Zhang, X., Luo, X. L., Zeng, C., Li, W., Gao, M., & Dong, Y. (2018) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-018-0536-9 · Cited by 86

A Systematic Review on COVID-19 Vaccine Strategies, Their Effectiveness, and Issues

Khandker, S. S., Godman, B., Jawad, M. I., Meghla, B. A., Tisha, T. A., Khondoker, M. U., Haq, M. A., Charan, J., Talukder, A. A., Azmuda, N., et al. (2021) · Vaccines · doi:10.3390/vaccines9121387 · Cited by 88

An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates

Ripoll, M., Bernard, M., Vaure, C., Bazin, E., Commandeur, S., Perkov, V., Lemdani, K., Nicolaï, M., Bonifassi, P., Kichler, A., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121570 · Cited by 89

Metal‐Organic Frameworks for Gene Therapy and Detection

He, Y., Li, D., Wu, L., Yin, X., Zhang, X., Patterson, L. H., & Zhang, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202212277 · Cited by 85

RNA delivery biomaterials for the treatment of genetic and rare diseases

Zhao, W., Hou, X., Vick, O. G., & Dong, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119291 · Cited by 82

In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration

Tanaka, H., Nakatani, T., Furihata, T., Tange, K., Nakai, Y., Yoshioka, H., Harashima, H., & Akita, H. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01084 · Cited by 82

mRNA-Based Vaccines and Therapeutics for COVID-19 and Future Pandemics

Chavda, V. P., Soni, S., Vora, L. K., Soni, S., Khadela, A. D., & Ajabiya, J. (2022) · Vaccines · doi:10.3390/vaccines10122150 · Cited by 89

A Universal GSH-Responsive Nanoplatform for the Delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein

Chen, G., Ma, B., Wang, Y., & Gong, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b03496 · Cited by 80

Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Ni, R., Feng, R., & Chau, Y. (2019) · Life · doi:10.3390/life9030059 · Cited by 84

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation

Melnyk, T., Đorđević, S., Conejos‐Sánchez, I., & Vicent, M. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.007 · Cited by 81

Current view on novel vaccine technologies to combat human infectious diseases

Matić, Z., & Šantak, M. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11713-0 · Cited by 83

RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?

Sandbrink, J. B., & Shattock, R. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.608460 · Cited by 80

Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability

Dirisala, A., Uchida, S., Tockary, T. A., Yoshinaga, N., Li, J., Osawa, S., Gorantla, L., Fukushima, S., Osada, K., & Kataoka, K. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1550646 · Cited by 76

Versatile Redox-Responsive Polyplexes for the Delivery of Plasmid DNA, Messenger RNA, and CRISPR-Cas9 Genome-Editing Machinery

Wang, Y., Ma, B., Abdeen, A. A., Chen, G., Xie, R., Saha, K., & Gong, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b09642 · Cited by 74

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

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The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

Blakney, A. K., McKay, P. F., Ibarzo Yus, B., Hunter, J. E., Dex, E. A., & Shattock, R. J. (2019) · ACS Nano · doi:10.1021/acsnano.9b01774 · Cited by 73

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Byun, M. J., Lim, J., Kim, S.-N., Park, D.-H., Kim, T. P., Park, W., & Park, C. G. (2022) · BioChip Journal · doi:10.1007/s13206-022-00052-5 · Cited by 78

The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of Vaccinology

Ye, Z., Harmon, J., Ni, W., Li, Y., Wich, D., & Xu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.2c12584 · Cited by 72

Nanomaterials for mRNA ‐based therapeutics: Challenges and opportunities

Li, D., Liu, Q., Yang, M., Xu, H., Zhu, M., Zhang, Y., Xu, J., Tian, C., Yao, J., Wang, L., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10492 · Cited by 74

In vitro evolution of enhanced RNA replicons for immunotherapy

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Recent advances in co-delivery nanosystems for synergistic action in cancer treatment

de Carvalho, B. G., Vit, F. F., Carvalho, H. F., Han, S. W., & de la Torre, L. G. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02168g · Cited by 74

Delivery of therapeutic oligonucleotides in nanoscale

Wu, L., Zhou, W., Lin, L., Chen, A., Feng, J. C., Qu, X., Zhang, H., & Yue, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.038 · Cited by 72

Recent advances in mRNA vaccine delivery

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Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

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Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer

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