No evidence of white adipocyte browning after endurance exercise training in obese men
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BACKGROUND/OBJECTIVES: The phenomenon of adipocyte 'beiging' involves the conversion of non-classic brown adipocytes to brown-like adipose tissue with thermogenic, fat-burning properties, and this phenomenon has been shown in rodents to slow the progression of obesity-associated metabolic diseases. Rodent studies consistently report adipocyte beiging after endurance exercise training, indicating that increased thermogenic capacity in these adipocytes may underpin the improved health benefits of exercise training. The aim of this study was to determine whether prolonged endurance exercise training induces beige adipogenesis in subcutaneous adipose tissues of obese men. SUBJECTS/METHODS: ). RESULTS: The mRNAs encoding the brown or beige adipocyte-selective proteins were very lowly expressed in AbSC and GF adipose tissues and exercise training did not alter the mRNA expression of UCP1, CD137, CITED, TBX1, LHX8 and TCF21. Using immunohistochemistry, neither multilocular adipocytes, nor UCP1 or CD137-positive adipocytes were detected in any sample. MicroRNAs known to regulate brown and/or beige adipose development were highly expressed in white adipocytes but endurance exercise training did not impact their expression. CONCLUSIONS: The present study reaffirms emerging data in humans demonstrating no evidence of white adipose tissue beiging in response to exercise training, and supports a growing body of work demonstrating divergence of brown/beige adipose location, molecular characterization and physiological function between rodents and humans.
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A human chronic exercise training study found no browning of WAT by biopsy.
“a study in humans of chronic exercise training, which did not find any browning of WAT (as assessed by biopsy)90.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [90]
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- Authors
- Tsiloulis, T., Carey, A. L., Bayliss, J., Canny, B., Meex, R. C. R., & Watt, M. J.
- Affiliations
- Monash University (AU)
- Baker Heart and Diabetes Institute (AU)
- University of Tasmania (AU)
- Maastricht University (NL)
- Corresponding author
- Watt, M J
- Venue
- International Journal of Obesity
- Published
- 2017-11-30
- Volume
- 42
- Issue
- 4
- Pages
- 721-727
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2771198119
- Cited by
- 70
- References
- 55
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 8
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- UTAS Research Repository (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1098972, 1077703)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipocyte browning, beige adipocytes, endurance training, obesity, white adipose tissue, brown adipose tissue, thermogenesis, UCP1, 4-1BB, subcutaneous adipose tissue, microRNA, gene expression
- MeSH terms
- Endurance Training, Humans, Male, Obesity, Cohort Studies, MicroRNAs, Subcutaneous Fat, Abdominal Fat, Adipocytes, Brown, Adipocytes, White
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