Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial
Open accessAbstract
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored the effects of dietary AGEs on the gut bacterial microbiota composition in similar patients. AGEs play an important role in the development and progression of cardiovascular (CVD) disease. Plasma concentrations of different bacterial products have been shown to predict the risk of incident major adverse CVD events independently of traditional CVD risk factors, and experimental animal models indicates a possible role AGEs might have on the gut microbiota population. In this pilot randomized open label controlled trial, twenty PD patients habitually consuming a high AGE diet were recruited and randomized into either continuing the same diet (HAGE, n = 10) or a one-month dietary AGE restriction (LAGE, n = 10). Blood and stool samples were collected at baseline and after intervention. Variable regions V3-V4 of 16s rDNA were sequenced and taxa was identified on the phyla, genus, and species levels. Dietary AGE restriction resulted in a significant decrease in serum Nε-(carboxymethyl) lysine (CML) and methylglyoxal-derivatives (MG). At baseline, our total cohort exhibited a lower relative abundance of Bacteroides and Alistipes genus and a higher abundance of Prevotella genus when compared to the published data of healthy population. Dietary AGE restriction altered the bacterial gut microbiota with a significant reduction in Prevotella copri and Bifidobacterium animalis relative abundance and increased Alistipes indistinctus, Clostridium citroniae, Clostridium hathewayi, and Ruminococcus gauvreauii relative abundance. We show in this pilot study significant microbiota differences in peritoneal dialysis patients' population, as well as the effects of dietary AGEs on gut microbiota, which might play a role in the increased cardiovascular events in this population and warrants further studies.
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AGE-modulated gut microflora is associated with the pathogenesis of type 2 DM, obesity, neurodegenerative diseases such as AD, and end-stage renal failure.
“AGE-modulated gut microflora is also associated with the pathogenesis of type 2 DM, obesity, neurodegenerative diseases such as AD, and end-stage renal failure, where restriction of dietary AGEs can improve the gut microbial composition and subsequently attenuate disease conditions100,101.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [100]
Restriction of dietary AGEs can improve gut microbial composition and subsequently attenuate disease conditions.
“where restriction of dietary AGEs can improve the gut microbial composition and subsequently attenuate disease conditions100,101.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [100]
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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
PEAR: a fast and accurate Illumina Paired-End reAd mergeR
Zhang, J., Kobert, K., Flouri, T., & Stamatakis, A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt593 · Cited by 4,497 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
The ecology of the microbiome: Networks, competition, and stability
Coyte, K. Z., Schlüter, J., & Foster, K. R. (2015) · Science · doi:10.1126/science.aad2602 · Cited by 2,728 · see citing works
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179 · see citing works
Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
Flint, H. J., Bayer, E. A., Rincón, M. T., Lamed, R., & White, B. A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1817 · Cited by 1,710 · see citing works
Advanced Glycation End Products and Diabetic Complications
Singh, V. P., Bali, A., Singh, N., & Jaggi, A. S. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.1.1 · Cited by 1,518 · see citing works
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,457 · see citing works
Impact of the gut microbiota on inflammation, obesity, and metabolic disease
Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016) · Genome Medicine · doi:10.1186/s13073-016-0303-2 · Cited by 1,438 · see citing works
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289 · see citing works
Self-citationChronic kidney disease alters intestinal microbial flora
Vaziri, N. D., Wong, J., Pahl, M., Piceno, Y. M., Yuan, J., DeSantis, T. Z., Ni, Z., Nguyen, T.-H., & Andersen, G. L. (2013) · Kidney International · doi:10.1038/ki.2012.345 · Cited by 1,164 · see citing works
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z. H., Skolnik, E. Y., DELANEY, V. B., Friedman, E. A., Cerami, A., & Vlassara, H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109193251202 · Cited by 917 · see citing works
Dynamics and associations of microbial community types across the human body
Ding, T., & Schloss, P. D. (2014) · Nature · doi:10.1038/nature13178 · Cited by 885 · see citing works
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860 · see citing works
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792 · see citing works
Activation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 792 · see citing works
Advanced glycoxidation end products in commonly consumed foods
Goldberg, T., Cai, W., Peppa, M., Dardaine, V., Baliga, B. S., Uribarri, J., & Vlassara, H. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.05.214 · Cited by 744 · see citing works
Self-citationObesity, Diabetes, and Gut Microbiota
Musso, G., Gambino, R., & Cassader, M. (2010) · Diabetes Care · doi:10.2337/dc10-0556 · Cited by 662 · see citing works
Advanced glycation end products
Gkogkolou, P., & Böhm, M. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22028 · Cited by 594 · see citing works
Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.4.427 · Cited by 570 · see citing works
Self-citationThe role of Gut Microbiota in the development of obesity and Diabetes
Baothman, O. A. S., Zamzami, M. A., Taher, I., Abubaker, J. A., & Abu‐Farha, M. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0278-4 · Cited by 494 · see citing works
Does accumulation of advanced glycation end products contribute to the aging phenotype?
Semba, R. D., Nicklett, E. J., & Ferrucci, L. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq074 · Cited by 490 · see citing works
Nutritional and toxicological aspects of the Maillard browning reaction in foods
O'Brien, J., Morrissey, P. A., & Ames, J. M. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527499 · Cited by 477 · see citing works
The role of the intestinal microbiota in type 1 diabetes mellitus
Knip, M., & Siljander, H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.218 · Cited by 434 · see citing works
Dietary Advanced Glycation End Products and Aging
Luevano-Contreras, C., & Chapman-Novakofski, K. (2010) · Nutrients · doi:10.3390/nu2121247 · Cited by 396 · see citing works
Advanced glycation end products and the kidney
Bohlender, J. M., Franke, S., Stein, G., & Wolf, G. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00398.2004 · Cited by 386 · see citing works
Lipocalin 2 protects from inflammation and Tumorigenesis associated with gut microbiota alterations
Moschen, A. R., Gerner, R. R., Wang, J., Klepsch, V., Adolph, T. E., Reider, S. J., Hackl, H., Pfister, A., Schilling, J., Moser, P. L., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.007 · Cited by 375 · see citing works
Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure
Makita, Z., Bucala, R., Rayfield, E. J., Fuh, H., Manogue, K. R., Cerami, A., Viassara, H., Friedman, E. A., Kaufman, A. M., Korbet, S. M., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92935-1 · Cited by 373 · see citing works
Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms
Stirban, A. O., Gawlowski, T., & Roden, M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.11.006 · Cited by 365 · see citing works
Role of advanced glycation end products in cardiovascular disease
Hegab, Z. (2012) · World Journal of Cardiology · doi:10.4330/wjc.v4.i4.90 · Cited by 354 · see citing works
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., He, C., & Vlassara, H. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000051593.41395.b9 · Cited by 331 · see citing works
Self-citationExploring the Diversity of the Bifidobacterial Population in the Human Intestinal Tract
Turroni, F., Foroni, E., Pizzetti, P., Giubellini, V., Ribbera, A., Merusi, P., Cagnasso, P., Bizzarri, B., de'Angelis, G. L., Shanahan, F., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02216-08 · Cited by 311 · see citing works
Advanced glycation end products: A nephrologist's perspective
Raj, D. S., Choudhury, D., Welbourne, T., & Levi, M. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70189-2 · Cited by 289 · see citing works
The Intestinal Microbiota in Metabolic Disease
Woting, A., & Blaut, M. (2016) · Nutrients · doi:10.3390/nu8040202 · Cited by 284 · see citing works
Beisswenger, P. J., Makita, Z., Curphey, T. J., Moore, L. L., Jean, S., Brinck‐Johnsen, T., Bucala, R., & Vlassara, H. (1995) · Diabetes · doi:10.2337/diab.44.7.824 · Cited by 253 · see citing works
Advanced glycation end‐products and the kidney
Busch, M., Franke, S., Rüster, C., & Wolf, G. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02317.x · Cited by 226 · see citing works
Peritoneal Dialysis for Acute Kidney Injury
Cullis, B., Abdelraheem, M. B., Abrahams, G., Balbi, A. L., Cruz, D. N., Frishberg, Y., Koch, V. H. K., McCulloch, M., Numanoğlu, A., Nourse, P. J., et al. (2014) · Peritoneal Dialysis International · doi:10.3747/pdi.2013.00222 · Cited by 211 · see citing works
He, C., Sabol, J., Mitsuhashi, T., & Vlassara, H. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1308 · Cited by 191 · see citing works
AGEs in foods: do they play a role in uremia?
Henle, T. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s84.16.x · Cited by 184 · see citing works
Meerwaldt, R., Links, T. P., Graaff, R., Hoogenberg, K., Lefrandt, J. D., Baynes, J., Gans, R. O. B., & Smit, A. J. (2005) · Diabetologia · doi:10.1007/s00125-005-1828-x · Cited by 181 · see citing works
Bread crust melanoidins as potential prebiotic ingredients
Borrelli, R. C., & Fogliano, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500011 · Cited by 177 · see citing works
Expanding role of gut microbiota in lipid metabolism
Ghazalpour, A., Cespedes, I., Bennett, B. J., & Allayee, H. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000278 · Cited by 171 · see citing works
Advanced Glycation End Products and Diabetic Cardiovascular Disease
Prasad, A., Bekker, P., & Tsimikas, S. (2012) · Cardiology in Review · doi:10.1097/crd.0b013e318244e57c · Cited by 150 · see citing works
Glycoxidation of biological macromolecules: A critical approach to halt the menace of glycation
Ahmad, S., Khan, M. S., Akhter, F., Khan, M. S., Khan, M. S., Ashraf, J. M., Pandey, R. P., & Shahab, U. (2014) · Glycobiology · doi:10.1093/glycob/cwu057 · Cited by 131 · see citing works
The effect of a model melanoidin mixture on faecal bacterial populations<i>in vitro</i>
Ames, J. M., Wynne, A., Hofmann, A., Plos, S., & Gibson, G. R. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001749 · Cited by 125 · see citing works
Eid, H. M., Wright, M. L., Kumar, N. V. A., Qawasmeh, A., Hassan, S. T. S., Mocan, A., Nabavi, S. M., Rastrelli, L., Atanasov, A. G., & Haddad, P. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00387 · Cited by 106 · see citing works
Glycoxidation and Diabetic Complications: Modern Lessons and a Warning?
Vlassara, H., & Uribarri, J. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000032406.84813.f6 · Cited by 105 · see citing works
Self-citationOttum, M. S., & Mistry, A. (2015) · Journal of clinical biochemistry and nutrition · doi:10.3164/jcbn.15-3 · Cited by 97 · see citing works
Accumulation of Advanced Glycation End Products, Measured as Skin Autofluorescence, in Renal Disease
Hartog, J. W. L., de Vries, A. P. J., Lutgers, H. L., Meerwaldt, R., Huisman, R. M., van Son, W. J., de Jong, P. E., & Smit, A. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.037 · Cited by 89 · see citing works
Kellow, N. J., Coughlan, M. T., Savige, G. S., & Reid, C. M. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-55 · Cited by 89 · see citing works
Cho, Y., Johnson, D. W., Badve, S. V., et al. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft050 · Cited by 84 · see citing works
The role of the intestinal microbiota in type 1 diabetes
Hara, N., Alkanani, A. K., Ir, D., Robertson, C. E., Wagner, B. D., Frank, D. N., & Zipris, D. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.12.001 · Cited by 82 · see citing works
Advanced Glycation End Products and Cardiovascular Disease
Peppa, Μ., & Raptis, S. (2008) · Current Diabetes Reviews · doi:10.2174/157339908784220732 · Cited by 74 · see citing works
Chen, Y., Wu, Y., Gan, X., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.079 · Cited by 70 · see citing works
Baig, M. H., Jan, A. T., Rabbani, G., Ahmad, K., Ashraf, J. M., Kim, T., Min, H., Lee, Y., Cho, W., Yeul, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06067-5 · Cited by 70 · see citing works
The Association between Peritoneal Dialysis Modality and Peritonitis
Lan, P. G., Johnson, D. W., McDonald, S. P., et al. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09730913 · Cited by 64 · see citing works
The Microbiome: a Revolution in Treatment for Rheumatic Diseases?
Rosenbaum, J. T., & Asquith, M. J. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0614-8 · Cited by 55 · see citing works
Advanced Glycosylation End Products in Continuous Ambulatory Peritoneal Dialysis Patients
Korbet, S. M., Makita, Z., Firanek, C. A., et al. (1993) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80933-4 · Cited by 54 · see citing works
Summary of Probiotic Activities of Bifidobacterium lactis HN019
Sanders, M. E. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225576.73385.f0 · Cited by 49 · see citing works
Aikawa, E., Fujita, R., Asai, M., Kaneda, Y., & Tamai, K. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0067 · Cited by 39 · see citing works
ADVANCED GLYCATION END PRODUCTS IN RENAL FAILURE: AN OVERVIEW
Noordzij, M. J., Lefrandt, J. D., & Smit, A. J. (2008) · Journal of Renal Care · doi:10.1111/j.1755-6686.2008.00038.x · Cited by 36 · see citing works
Glycation & the RAGE axis: targeting signal transduction through DIAPH1
Shekhtman, A. G., Ramasamy, R., & Schmidt, A. M. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1271719 · Cited by 35 · see citing works
Microbiome: Ecology of stable gut communities
McNally, L., & Brown, S. P. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2015.16 · Cited by 30 · see citing works
Editorial: Can Prevotella copri Be a Causative Pathobiont in Rheumatoid Arthritis?
Kim, D.-H., & Kim, W. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39807 · Cited by 22 · see citing works
Yu, T., Zheng, Y., Wang, Y., Xiong, W., & Lin, L. (2016) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2016.12.002 · Cited by 19 · see citing works
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- Authors
- Yacoub, R., Nugent, M., Cai, W., Nadkarni, G. N., Chaves, L. D., Abyad, S., Honan, A. M., Thomas, S. A., Zheng, W., Valiyaparambil, S. A., Bryniarski, M. A., Sun, Y., Buck, M., Genco, R. J., Quigg, R. J., He, J. C., & Uribarri, J.
- Affiliations
- University at Buffalo, State University of New York (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Yacoub, Rabi
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-09-20
- Volume
- 12
- Issue
- 9
- Pages
- e0184789
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5607175
- OpenAlex
- W2754799198
- Cited by
- 139
- References
- 69
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 11 · 2023: 23 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 14 · 2018: 12 · 2014: 1
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Center for Advancing Translational Sciences (UL1TR001412)
- University at Buffalo (Genome, Enviroment and Microbiome, Genome, Enviroment, and Microbiome, Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT))
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK107908-01A1)
- National Institutes of Health (RO1AI125982, RO1DE024523, I01BX000345, R01DK078897)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- advanced glycation end products, gut microbiota, peritoneal dialysis, end-stage renal disease, cardiovascular disease, carboxymethyllysine, methylglyoxal, Prevotella copri, Bacteroides, Alistipes, Bifidobacterium animalis, Clostridium, 16S rRNA gene sequencing
- MeSH terms
- Gastrointestinal Microbiome, Cardiovascular Diseases, Diet, Feces, Female, Humans, Kidney Failure, Chronic, Male, Middle Aged, Peritoneal Dialysis, Pilot Projects, Glycation End Products, Advanced
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